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Mark Lifman murder: Call for a ban on media photographers




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IFMA Releases Industry and Segment Forecast for Food-Away-From-Home

The International Foodservice Manufacturers Association (IFMA) released its final 2023 estimates and its latest 2024 Food Away-From-Home (FAFH) Industry and Segment Projections.




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IFMA The Food Away from Home Association

After the pandemic years, it became clear that the foodservice supply chain and ecosystem are interconnected, with manufacturers, operators, and distribution partners needing each other to address critical challenges. 




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Underworld figure Lifman removed from indictment following murder




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IFM’s Hat Trick and Reflections On Option-To-Buy M&A

Today IFM Therapeutics announced the acquisition of IFM Due, one of its subsidiaries, by Novartis. Back in Sept 2019, IFM granted Novartis the right to acquire IFM Due as part of an “option to buy” collaboration around cGAS-STING antagonists for

The post IFM’s Hat Trick and Reflections On Option-To-Buy M&A appeared first on LifeSciVC.




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Watford fighter Ellie Harber wins IFMA Great Britain Team Trials

Watford fighter Ellie Harber took her 2020 record to five wins from five, culminating last weekend at the IFMA Great Britain Team Trials at Watford’s Woodside Leisure Centre.




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IFMC, Inc., Announces New Contest for Snore Free

A social media campaign, which rewards Snore Free customers for creating funny or creative pictures, that show how they are using the product.




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ISITC and SIFMA AMG Collaborate on Market Practice for Margin Call Process

In standardizing the collateral call process, industry players will benefit from improved operational, liquidity and counterparty risk management




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Financial Institutions e-briefing: AIFMD update

FSA survey on AIFMD – aiming to provide support to AIFMs On 11 March 2013, the Financial Services Authority (“FSA”) published new web-pages on the Alternative Investment Fund Managers Directive (“AIFMD”), including an o...




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Financial Institutions E-briefing: AIFMD update: FSA and the Treasury publish further consultations on implementation of AIFMD

On 19 March, the Financial Services Authority published its much anticipated second consultation on AIFMD: “Implementation of the Alternative Investment Fund Managers Directive” – CP 13/9. The FSA paper came hot on the heels of HM ...




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AIFMD update: ESMA updates AIFMD Q&As and delays opinion on the extension of the AIFMD passport to non-EU entities

Updated AIFMD Q&As The European Securities and Markets Authority (ESMA) has published an updated version of its Q&A paper on the application of the Alternative Investment Fund Managers Directive (AIFMD). This publication was released on...




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AIFMD update: CSSF provides clarification on marketing and reverse solicitation

The Luxembourg regulator, the Commission de Surveillance du Secteur Financier (CSSF) has provided guidance on the meaning of marketing and reverse solicitation under AIFMD. This guidance is to be welcomed, as there is no European-wide guidance on th...




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Leverage under the AIFMD: some rare guidance

On 7 August 2018, ESMA published a letter from Steven Maijoor, ESMA Chair, to Gabriel Bernardino, EIOPA Chair. The letter addressed the question of whether ESMA would consider borrowing arrangements and derivative arrangements entered into by an Alt...




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EU Securitisation Regulation – Considerations for AIFMs, UCITS managers and institutional investors

Overview The Securitisation Regulation (Regulation) comes into force on 1 January 2019, establishes a general framework for securitisation and creates a specific framework for simple, transparent and standardised securitisation. The Regulation is a ...




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Cerebellar ataxia, neuropathy, hearing loss, and intellectual disability due to AIFM1 mutation

Objective

To describe the clinical and molecular genetic findings in a family segregating a novel mutation in the AIFM1 gene on the X chromosome.

Methods

We studied the clinical features and performed brain MRI scans, nerve conduction studies, audiometry, cognitive testing, and clinical exome sequencing (CES) in the proband, his mother, and maternal uncle. We used in silico tools, X chromosome inactivation assessment, and Western blot analysis to predict the consequences of an AIFM1 variant identified by CES and demonstrate its pathogenicity.

Results

The proband and his maternal uncle presented with childhood-onset nonprogressive cerebellar ataxia, hearing loss, intellectual disability (ID), peripheral neuropathy, and mood and behavioral disorder. The proband's mother had mild cerebellar ataxia, ID, and mood and behavior disorder, but no neuropathy or hearing loss. The 3 subjects shared a variant (c.1195G>A; p.Gly399Ser) in exon 12 of the AIFM1 gene, which is not reported in the exome/genome sequence databases, affecting a critical amino acid for protein function involved in NAD(H) binding and predicted to be pathogenic with very high probability by variant analysis programs. X chromosome inactivation was highly skewed in the proband's mother. The mutation did not cause quantitative changes in protein abundance.

Conclusions

Our report extends the molecular and phenotypic spectrum of AIFM1 mutations. Specific findings include limited progression of neurologic abnormalities after the first decade and the coexistence of mood and behavior disorder. This family also shows the confounding effect on the phenotype of nongenetic factors, such as alcohol and drug use and side effects of medication.




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You failed your math test, comrade Einstein [electronic resource] : adventures and misadventures of young mathematicians or test your skills in almost recreational mathematics / edited by M. Shifman




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George Placzek: a nuclear physicist's odyssey / Aleš Gottvald (Academy of Sciences, Czech Republic), Misha Shifman (University of Minnesota, USA)

Hayden Library - QC774.P53 G65 2018