hybrids

In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP

RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
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hybrids

Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation

RSC Med. Chem., 2024, 15,3778-3794
DOI: 10.1039/D4MD00281D, Research Article
Carolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. Pilli
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
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hybrids

Equity Derivatives and Hybrids Markets, Models and Methods

Location: Electronic Resource- 




hybrids

Fabrication of MoS2/rGO hybrids as electrocatalyst for water splitting applications

RSC Adv., 2024, 14,12742-12753
DOI: 10.1039/D4RA00697F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Shahzeb Khan, Tayyaba Noor, Erum Pervaiz, Naseem Iqbal, Neelam Zaman
Environmental degradation and energy constraint are important risks to long-term sustainability in the modern world.
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hybrids

Polymeric polyiodo-chlorotellurates(IV): new supramolecular hybrids in halometalate chemistry

CrystEngComm, 2024, 26,2018-2024
DOI: 10.1039/D4CE00088A, Paper
Nikita A. Korobeynikov, Andrey N. Usoltsev, Maxim N. Sokolov, Alexander S. Novikov, Sergey A. Adonin
Reaction between TeO2 and I2 in HCl afforded a series of supramolecular hybrids Cat2{[TeCl6](I2)} (1–5) where diiodine fragments are linked to [TeCl6]2− octahedra via halogen bonds (XB).
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hybrids

Design, synthesis, biological evaluation and molecular docking studies of quinoline-anthranilic acid hybrids as potent anti-inflammatory drugs

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00040D, Paper
Sidra Siddique, Khalid Hussain, Naureen Shehzadi, Muhammad Arshad, Muhammad Nadeem Arshad, Sadaf Iftikhar, Farhat Saghir, Ayisha Shaukat, Muhammad Sarfraz, Nisar Ahmed
Despite the high global prevalence, rheumatoid arthritis lacks a satisfactory treatment.
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hybrids

Unravelling Structure - Luminescence Relationship in Two Dimensional Antimony(III) Doped Cadmium (II) Halide Hybrids

J. Mater. Chem. C, 2024, Accepted Manuscript
DOI: 10.1039/D4TC03543G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ashwath Kudlu, Dhritismita Sarma, Deep K Das, Alisha Basheer Shamla, Rangarajan Bakthavatsalam, Venkatesha R. Hathwar, Arup Mahata, Janardan Kundu
Luminescent zero dimensional (0D) antimony halide (Sb-X) hybrids showcase emissive properties (emission peak position; photoluminescence quantum yield-PLQY) that are strongly dependent on the local metal halide geometry/site asymmetry. However, controlling...
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hybrids

Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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hybrids

Design, synthesis, and in vitro and in vivo biological evaluation of triazolopyrimidine hybrids as multitarget directed anticancer agents

RSC Adv., 2024, 14,35239-35254
DOI: 10.1039/D4RA06704E, Paper
Open Access
Heba A. Adawy, Samar S. Tawfik, Abdullah A. Elgazar, Khalid B. Selim, Fatma E. Goda
In response to the urgent need for new anti-proliferative agents, four novel series of triazolopyrimidine compounds (7a–e, 9a–d, 11a–f, and 13a–e) were synthesized and evaluated for in vitro and in vivo anticancer efficacy.
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hybrids

From luxury SUVs to city-smart hybrids, here’s a quick look at the cars that are turning heads this month

This month has been unusually busy in the Indian automotive industry with most major players dropping new models. Here’s a roundup of what we drove.



  • Life & Style

hybrids

Tripeptide-dopamine fluorescent hybrids: a coassembly-inspired antioxidative strategy

Chem. Commun., 2020, Advance Article
DOI: 10.1039/D0CC01882A, Communication
Jun Guo, Fan Zheng, Bo Song, Feng Zhang
Coassembling peptides with dopamine molecules can construct hybrid nanostructures with a large Stokes shift green fluorescence, which is an effective antioxidative strategy for biomolecules.
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hybrids

Zipcar adds Prius plug-in hybrids

Car sharing service Zipcar will be adding Toyota Prius plug-in hybrids to its fleet.




hybrids

Millennials like hybrids, women like SUVs and self-driving cars get a collective 'meh'

Two new studies decipher who prefers which kind of car, revealing unexpected attitudes that challenge many assumptions.




hybrids

UPS adds 200 hybrids to U.S. fleet

Next time you see one of UPS' iconic big brown delivery trucks, look closely because it may be one of the 200 new hybrids hitting the streets of American cities




hybrids

Detroit Auto Show: BMW's hybrids combine muscle and mileage

BMW is fielding an all-new 3-Series, and with it an ActiveHybrid 3 that offers both zero to 60 in 5.6 seconds and about 37 mpg. Up a notch, there's the ActiveHy




hybrids

For Europe's new plug-in hybrids, price matters (a lot)

Audi and Volvo will roll out luxury electric cars in the U.S. market early next year.




hybrids

4 plug-in hybrids making noise at Detroit Auto Show

Despite $2 a gallon gas, automakers are still going green, and the popularity of the gas-electric range extender format is just one example.




hybrids

Despite $2 gas, Kia shows off 3 new hybrids at Chicago Auto Show

The all-new Niro is joined by revamped versions of the Optima.




hybrids

Buck Rogers in 2013: Carbon-neutral e-gas cars and hydraulic hybrids

e-gas cars and hydraulic hybrids




hybrids

For fire-breathing supercars, hybrids are the future

Aston Martin's chief is bad-mouthing hybrids and thinks his "V-12 is something special." I beg to differ. His cars get dismal fuel economy.




hybrids

Los Angeles Auto Show preview: Hot hatches, hybrids and electric vehicles

The LA show, opening this week, features some intriguing green concept cars...headed for production. Are you ready for a compact hybrid Lexus, a 170-mpg VW and




hybrids

Explorer vs Pilot, 2020 Genesis G70 review, Camry vs Sonata Hybrids: What's New @ The Car Connection

2020 Honda Pilot vs. 2020 Ford Explorer: Compare Crossover SUVs Two of the bestselling three-row SUVs, the 2020 Honda Pilot and 2020 Ford Explorer, go about their family business a bit differently. Pickup trucks outsell cars for the first time, and it may not be temporary The Ford F-150, Ram 1500, and Chevy Silverado have been the best-selling...



  • Today in Car News

hybrids

The Transcriptional Aftermath in Two Independently Formed Hybrids of the Opportunistic Pathogen Candida orthopsilosis

ABSTRACT

Interspecific hybridization can drive evolutionary adaptation to novel environments. The Saccharomycotina clade of budding yeasts includes many hybrid lineages, and hybridization has been proposed as a source for new pathogenic species. Candida orthopsilosis is an emerging opportunistic pathogen for which most clinical isolates are hybrids, each derived from one of at least four independent crosses between the same two parental lineages. To gain insight into the transcriptomic aftermath of hybridization in these pathogens, we analyzed allele-specific gene expression in two independently formed hybrid strains and in a homozygous strain representative of one parental lineage. Our results show that the effect of hybridization on overall gene expression is rather limited, affecting ~4% of the genes studied. However, we identified a larger effect in terms of imbalanced allelic expression, affecting ~9.5% of the heterozygous genes in the hybrids. This effect was larger in the hybrid with more extensive loss of heterozygosity, which may indicate a tendency to avoid loss of heterozygosity in these genes. Consistently, the number of shared genes with allele-specific expression in the two independently formed hybrids was higher than random expectation, suggesting selective retention. Some of the imbalanced genes have functions related to pathogenicity, including zinc transport and superoxide dismutase activities. While it remains unclear whether the observed imbalanced genes play a role in virulence, our results suggest that differences in allele-specific expression may add an additional layer of phenotypic plasticity to traits related to virulence in C. orthopsilosis hybrids.

IMPORTANCE How new pathogens emerge is an important question that remains largely unanswered. Some emerging yeast pathogens are hybrids originated through the crossing of two different species, but how hybridization contributes to higher virulence is unclear. Here, we show that hybrids selectively retain gene regulation plasticity inherited from the two parents and that this plasticity affects genes involved in virulence.




hybrids

Genetic structure in hybrids and progenitors provides insight into processes underlying an invasive cattail (<i>Typha</i> × <i>glauca</i>) hybrid zone




hybrids

Toyota Recalls 3.8 Million Vehicles, Including Prius Hybrids

Photo: Wikipedia, Public domain 2004 to 2009 Prius Included in Toyota's September 2009 Recall Toyota has just announced a huge recall. About 3.8 million vehicles are included, and that includes the 2004 to 2009 Prius hybrid. Since that's probably a




hybrids

Kaizen Fail: Toyota Recalls 437,000 Hybrids Worldwide, Mostly 2010 Prius Models

Photo: Toyota Ouch We all knew it was coming, but now it's official. Toyota has formally filed a voluntary recall for 437,000 hybrid vehicles worldwide. Most of those are third generation Prius hybrids, but they're also recalling the few Prius PHEV out




hybrids

Zipcar Stops Renting 2010 Prius Hybrids Until Brake Problems are Fixed

Apologies for the bad Photoshop job... Photo: Zipcar Logo, Toyota Less Than 1% of Zipcar Fleet, But... I'm pretty sure that many TreeHugger readers are also Zipcar customers (car-sharing in general is booming), and chances are that with that crowd, the




hybrids

Waymo may get a $465 million tax credit for buying 62,000 Chrysler Pacifica hybrids

They are going to be autonomous taxis. Is this a good idea?




hybrids

[ASAP] Design and Synthesis of Cyclometalated Iridium(III) Complexes—Chromophore Hybrids that Exhibit Long-Emission Lifetimes Based on a Reversible Electronic Energy Transfer Mechanism

Inorganic Chemistry
DOI: 10.1021/acs.inorgchem.0c00363




hybrids

Unravelling the nucleation, growth, and faceting of magnetite–gold nanohybrids

J. Mater. Chem. B, 2020, 8,3886-3895
DOI: 10.1039/C9TB02721A, Paper
Yulia A. Nalench, Igor V. Shchetinin, Alexander S. Skorikov, Pavel S. Mogilnikov, Michael Farle, Alexander G. Savchenko, Alexander G. Majouga, Maxim A. Abakumov, Ulf Wiedwald
The nucleation, growth and faceting of Fe3O4–Au nanoparticles is systematically monitored using liquid probes during reaction. Two consecutive processes are obtained, the growth of Fe3O4 spheres on Au seeds and faceting towards octahedral motifs.
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hybrids

Molecular transport in ionic liquid/nanomembrane hybrids

Phys. Chem. Chem. Phys., 2020, 22,9808-9814
DOI: 10.1039/D0CP01233E, Paper
Daniil Naberezhnyi, Petr Dementyev
Molecular transport in ultrathin membranes changes upon surface functionalization.
The content of this RSS Feed (c) The Royal Society of Chemistry




hybrids

[ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.9b00669




hybrids

Nonlinear organic–inorganic halide hybrids containing unprecedented linear [MIX2]− coordination units and quasi-two-dimensional lone pairs

Chem. Commun., 2020, 56,4894-4897
DOI: 10.1039/D0CC01532F, Communication
Qi Wu, Xian Liu, Yeshuang Du, Chunlin Teng, Fei Liang
A first example of monovalent-metal-based hybrid halides [N(CH3)4]MCl2 (M = Ga+, In+) with zero-dimensional configuration containing unprecedented linear [GaCl2]/[InCl2] units have been designed and synthesized.
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hybrids

An expedient synthesis of new imino-thiazolidinone grafted dispiro-pyrrolidine-oxindole/indeno hybrids via a multicomponent [3+2] cycloaddition reaction in a deep eutectic solvent

New J. Chem., 2020, Advance Article
DOI: 10.1039/D0NJ00801J, Paper
Ruby Singh, Munna Ram Saini, Diksha Bhardwaj, Aakash Singh
A facile and selective synthesis of novel factionalized dispiro-pyrrolidines via a three component [3+2] cycloaddition reaction using a deep eutectic solvent.
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hybrids

Nanohybrids in environmental & biomedical applications / edited by Surender Kumar Sharma

Online Resource




hybrids

Nitro-graphene oxide in iridium oxide hybrids: electrochemical modulation of N-graphene redox states and charge capacities

Mater. Chem. Front., 2020, 4,1421-1433
DOI: 10.1039/C9QM00752K, Research Article
Open Access
E. Pérez, N. M. Carretero, S. Sandoval, A. Fuertes, G. Tobias, N. Casañ-Pastor
Electrochemical modulation of N-graphene oxide in IrOx hybrids results in an oxidizing range of graphenes and large charge capacities.
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hybrids

Reversible changes in the electronic structure of carbon nanotube-hybrids upon NO2 exposure under ambient conditions

J. Mater. Chem. A, 2020, Advance Article
DOI: 10.1039/D0TA02749A, Paper
Open Access
Filippo Fedi, Oleg Domanov, Hidetsugu Shiozawa, Kazuhiro Yanagi, Paolo Lacovig, Silvano Lizzit, Andrea Goldoni, Thomas Pichler, Paola Ayala
Single-walled carbon nanotubes have enormous potential for gas sensing. This study shows that cluster filling is a key to high sensitivity and it opens the possibility for a very high desorption at ambient temperature.
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hybrids

Correlation between crystal structures and polar (ferroelectric) properties of hybrids of haloantimonates(III) and halobismuthates(III)

Inorg. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QI00265H, Review Article
R. Jakubas, M. Rok, K. Mencel, G. Bator, A. Piecha-Bisiorek
Halogenoantimonates(III) and halogenobismuthates(III) are a highly versatile class of organic–inorganic hybrid materials, applicable in optoelectronics and switchable dielectric devices.
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hybrids

Podcast: The rise of skeletons, species-blurring hybrids, and getting rightfully ditched by a taxi

This week we chat about why it’s hard to get a taxi to nowhere, why bones came onto the scene some 550 million years ago, and how targeting bacteria’s predilection for iron might make better vaccines, with Online News Editor Catherine Matacic. Plus, Science’s Alexa Billow talks with news writer Elizabeth Pennisi about the way hybrids muck up the concept of species and turn the evolutionary tree into a tangled web.   Listen to previous podcasts   [Image:  Raul González Alegría; Music: Jeffrey Cook]




hybrids

[ASAP] Self-Enhanced Chemiluminescence of Tris(bipyridine) Ruthenium(II) Derivative Nanohybrids: Mechanism Insight and Application for Sensitive Silver Ions Detection

Analytical Chemistry
DOI: 10.1021/acs.analchem.0c00897




hybrids

[ASAP] Development of Au and 1D Hydroxyapatite Nanohybrids Supported on 2D Boron Nitride Sheets as Highly Efficient Catalysts for Dehydrogenating Glycerol to Lactic Acid

ACS Sustainable Chemistry & Engineering
DOI: 10.1021/acssuschemeng.9b06997