She was a Persian noblewoman during the reign of Chosroës II (590-628). Through a vision of an angel, she came to belief in Christ and received holy baptism; her name in baptism was Maria. Her furious husband reported her to King Chosroës, who had her thrown into a foul dungeon known as Oblivion for eighteen years. During these years she was repeatedly told to renounce Christ and was tormented in many ways. She was thrown to venomous snakes, which refused to harm her. Some lawless young men were sent to her cell to defile her, but God made her invisible to them. Many Persians, amazed and inspired by her patient sufferings, accepted Christ. She was finally set free through the visitation of an angel, traveled to Jerusalem and Constantinople, and reposed in peace.   She is commemorated July 12 on the Slavic calendar. Oddly, she is called a Martyr in all accounts, though she died free and in peace; presumably her eighteen years of cruel imprisonment earned her the title.

She was a Persian noblewoman during the reign of Chosroës II (590-628). Through a vision of an angel, she came to belief in Christ and received holy baptism; her name in baptism was Maria. Her furious husband reported her to King Chosroës, who had her thrown into a foul dungeon known as Oblivion for eighteen years. During these years she was repeatedly told to renounce Christ and was tormented in many ways. She was thrown to venomous snakes, which refused to harm her. Some lawless young men were sent to her cell to defile her, but God made her invisible to them. Many Persians, amazed and inspired by her patient sufferings, accepted Christ. She was finally set free through the visitation of an angel, traveled to Jerusalem and Constantinople, and reposed in peace.   She is commemorated July 12 on the Slavic calendar. Oddly, she is called a Martyr in all accounts, though she died free and in peace; presumably her eighteen years of cruel imprisonment earned her the title.

She was a Persian noblewoman during the reign of Chosroës II (590-628). Through a vision of an angel, she came to belief in Christ and received holy baptism; her name in baptism was Maria. Her furious husband reported her to King Chosroës, who had her thrown into a foul dungeon known as Oblivion for eighteen years. During these years she was repeatedly told to renounce Christ and was tormented in many ways. She was thrown to venomous snakes, which refused to harm her. Some lawless young men were sent to her cell to defile her, but God made her invisible to them. Many Persians, amazed and inspired by her patient sufferings, accepted Christ. She was finally set free through the visitation of an angel, traveled to Jerusalem and Constantinople, and reposed in peace.   She is commemorated July 12 on the Slavic calendar. Oddly, she is called a Martyr in all accounts, though she died free and in peace; presumably her eighteen years of cruel imprisonment earned her the title.

She was a Persian noblewoman during the reign of Chosroës II (590-628). Through a vision of an angel, she came to belief in Christ and received holy baptism; her name in baptism was Maria. Her furious husband reported her to King Chosroës, who had her thrown into a foul dungeon known as Oblivion for eighteen years. During these years she was repeatedly told to renounce Christ and was tormented in many ways. She was thrown to venomous snakes, which refused to harm her. Some lawless young men were sent to her cell to defile her, but God made her invisible to them. Many Persians, amazed and inspired by her patient sufferings, accepted Christ. She was finally set free through the visitation of an angel, traveled to Jerusalem and Constantinople, and reposed in peace.   She is commemorated July 12 on the Slavic calendar. Oddly, she is called a Martyr in all accounts, though she died free and in peace; presumably her eighteen years of cruel imprisonment earned her the title.

Fresh off a big win in the PR category at Cannes, Matt Neale joins the podcast to talk about award-winning work and more.

Manufacturing

In a personal interview with Dr. Linda Livingstone, Leslie Margolin, President and General Manager of Anthem Blue Cross, discusses her career progression and issues in the health care reform debate.

Leslie A. Margolin, President and General Manager of Anthem Blue Cross, talks about the issues and changes in health care. (Part 1 of 2)

Leslie Margolin, President and General Manager of Anthem Blue Cross, sits down for an interview with Dr. Linda Livingstone, Dean of the Graziadio School of Business and Management. Leslie also answers various questions from audience members. (Part 2 of 2)

In a follow-up interview with Dr. Linda Livingstone, Leslie Margolin, President and General Manager of Anthem Blue Cross, discusses the recent passing of the health care bill and how it impacts businesses and individuals.

It seems that there is rampant poaching of pangolins taking place during the lockdown in the Konkan belt, and their scales are being illegally sold in the local black market. During the raids, the forest department recovered two kilograms of pangolin scales and six nails. The pangolin is one of the most trafficked wild animals across the world as there is a huge international demand for its scales.

Range Forest Officer (RFO), Vaibhav Borate, said, "Based on the tip-off received from our sources, our forest department team raided the house of Kalpesh Tukaram Balgude at Karanjali [Balgudewadi] village near Dapoli. During the search operation of the house, our team recovered one tortoise shell, one jungle hare, and 22 kg of pangolin scales and nails. We have taken the accused into custody and investigation is on."

As evidence related to wildlife trade have been found from the house of the accused, the forest department is exploring the possibility of him doing this regularly. The forest department team has registered an offence under various sections of the Wildlife Protection Act, 1972.

According to the Wildlife Crime Control Bureau (WCCB) website, "Major threats to pangolins in India are hunting and poaching for local consumptive use and international trade. Another reason for hunting pangolin is its meat. There is now greater evidence of its inclusion in illicit international trade, in particular its scales, from India through Myanmar to China and South-East Asian countries as the most likely, final destinations. Inadequate information on population and distribution further accentuates the threats arising from hunting and poaching."

The Indian Pangolin is found sporadically throughout the plains and lower slopes of hills from south of the Himalayas to Kanyakumari, except the north-eastern region. The Chinese Pangolin is found in India in Sikkim, Arunachal Pradesh, Meghalaya, Nagaland, Assam, Manipur, Tripura, Mizoram and the northern part of West Bengal.

Why Pangolins?

Pangolins are the most trafficked mammal in the world, for their scales [made of keratin], which are boiled off their bodies for use in traditional medicine. Their meat is a delicacy in Vietnam and China; and their blood, which is considered to be a healing tonic.

Pangolin could help find cure for COVID-19?

Soon after the outbreak of COVID-19 pandemic, there were many media reports that claimed that the endangered pangolin was linked to the initial outbreak of the disease in China. However, this hasn't been proven yet. Now, a research conducted by the Medical University of Vienna in Austria, has revealed that certain genes sense when a virus enters the body, and trigger an immune response in most mammals. They found that pangolins, which have been called the 'missing link' between bats and humans, lack two of those virus-sensing genes. This means that not only are the endangered animals carriers, but they also seem to be immune to it, via an unknown mechanism. This evolutionary advantage and its understanding may give way to possible treatment options for COVID-19.

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London, May 8: The anteater-like mammals, pangolins, possess an evolutionary advantage against coronavirus, according to researchers, who say that understanding the animal's immune system may help develop new treatment options for COVID-19. According to the scientists from the Medical

One of Earth’s most evolutionarily unique species is also the world’s most trafficked mammal: pangolins, or “scaly anteaters.” A new study from the Smithsonian Conservation […]

The post Using genetics to help save world’s most trafficked mammal: the pangolin appeared first on Smithsonian Insider.

All 8 species of pangolin are in decline due to illegal trade, but conservationists hope to save them by softening the scaly animal's image.

Title: Pangolins Hold Clues to How COVID-19 Began -- and Might End
Category: Health News
Created: 5/8/2020 12:00:00 AM
Last Editorial Review: 5/8/2020 12:00:00 AM

Learning more about this evolutionary advantage in pangolins may suggest possible treatments for coronavirus in humans, the team said.

ABSTRACT

In numerous instances, tracking the biological significance of a nucleic acid sequence can be augmented through the identification of environmental niches in which the sequence of interest is present. Many metagenomic data sets are now available, with deep sequencing of samples from diverse biological niches. While any individual metagenomic data set can be readily queried using web-based tools, meta-searches through all such data sets are less accessible. In this brief communication, we demonstrate such a meta-metagenomic approach, examining close matches to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in all high-throughput sequencing data sets in the NCBI Sequence Read Archive accessible with the "virome" keyword. In addition to the homology to bat coronaviruses observed in descriptions of the SARS-CoV-2 sequence (F. Wu, S. Zhao, B. Yu, Y. M. Chen, et al., Nature 579:265–269, 2020, https://doi.org/10.1038/s41586-020-2008-3; P. Zhou, X. L. Yang, X. G. Wang, B. Hu, et al., Nature 579:270–273, 2020, https://doi.org/10.1038/s41586-020-2012-7), we note a strong homology to numerous sequence reads in metavirome data sets generated from the lungs of deceased pangolins reported by Liu et al. (P. Liu, W. Chen, and J. P. Chen, Viruses 11:979, 2019, https://doi.org/10.3390/v11110979). While analysis of these reads indicates the presence of a similar viral sequence in pangolin lung, the similarity is not sufficient to either confirm or rule out a role for pangolins as an intermediate host in the recent emergence of SARS-CoV-2. In addition to the implications for SARS-CoV-2 emergence, this study illustrates the utility and limitations of meta-metagenomic search tools in effective and rapid characterization of potentially significant nucleic acid sequences.

IMPORTANCE Meta-metagenomic searches allow for high-speed, low-cost identification of potentially significant biological niches for sequences of interest.

Wildlife conservation efforts are essential to preventing outbreaks, scientists and advocates say

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For more than five years, wildlife conservationists in the US have been clamoring for the government to provide Endangered Species Act protections to pangolins, a group of imperiled ant-eating mammals that are widely, and often illicitly, trafficked for their scales and meat. The Trump administration, however, has refused to act and that refusal has suddenly taken on grave new implications.

Earlier this year, scientists in China identified pangolins, along with bats, as one of the possible animal hosts involved in the transmission of the deadly coronavirus from wildlife to humans.

Pangolins lack two genes that function to sound the alarm when a virus enters the body, triggering an immune response in most other mammals. The findings from the Medical University of Vienna, Austria, are significant because, while the exotic animals can be carriers of coronavirus, they appear able to tolerate it through some other unknown mechanism. Understanding how pangolins are able to survive coronavirus may point to possible treatment options for humans.

It was already bad enough that a Chinese boat crashed into the Tubbataha reef, a protected coral reef off the coast of the Philippines, but what the coast guard found inside increased massively the size of the environmental disaster.

A community effort in Cambodia’s Cardamom Mountains offers hope for this unique mammal.

In spite of their protected status under international laws, pangolins remain one of the most trafficked animals in the world — and at least some of that trade is taking place right out in the open on Facebook . A new report from tech watchdog group the Tech Transparency Project details how Facebook users are […]

In spite of their protected status under international laws, pangolins remain one of the most trafficked animals in the world — and at least some of that trade is taking place right out in the open on Facebook . A new report from tech watchdog group the Tech Transparency Project details how Facebook users are […]

More than 300 pangolins are poached from the wild every day and make it the most trafficked animal. But the genome sequence of coronavirus in pangolins was a 99 per cent match to that of infected patients.

Pangolins - which lack a virus-sensing gene, meaning they can carry the virus without necessarily suffering - may hold the key to beating COVID-19, Austrian researchers said.

London, May 8: The anteater-like mammals, pangolins, possess an evolutionary advantage against coronavirus, according to researchers, who say that understanding the animal's immune system may help develop new treatment options for COVID-19. According to the scientists from the Medical

Trafficked scaly anteaters found to carry coronaviruses related to SARS-CoV-2

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