Title: Heart Attack (Myocardial Infarction)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 5/12/2022 12:00:00 AM

Colombia: Juan Manuel Santos seeks the path of dialogue with FARC In an unprecedented agreement, the government of Colombian President Juan Manuel Santos and the Revolutionary Armed Forces of Colombia (FARC) signed on Monday (27), in Havana, Cuba, an agreement to end the armed conflict in the country, which has lasted almost 50 years. The guerrillas gave several statements seeking a way out of the situation in Colombia through dialogue. The content of the agreement will be revealed soon by the Colombian representative, according to the multistate TeleSUR TV.

Why vote? They’ll just ignore you says Steve Beauchampé.

Panelistas creen que debe haber verdad para construir legitimidad y confianza; sostienen que en lo jurídico hay argumentos válidos.

Panelistas esperan que el Tribunal de Paz, que tendrá la última palabra, realice cambios en materia de las sanciones, la relación con el ejercicio político y el rol de las víctimas.

Expertos analizaron los cambios en la política colombiana a partir de la firma del Acuerdo, así como el panorama para el partido Comunes en las elecciones regionales.

Panelistas consideran que exmiembros de las Farc se equivocan en acusaciones a la JEP, pero creen que hay razón en los reclamos en temas como macrocasos y comparecientes de mandos bajos y medios.

Este es el Personaje del Día de María Alejandra Villamizar.

Escuche el programa de este viernes 6 de octubre. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña desde hace más de 30 años a sus oyentes en el regreso a casa.

Escuche el programa de este jueves 8 de febrero. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que acompaña por más de 30 años a sus oyentes en su regreso a casa. 

Escuche el programa de este lunes 11 de marzo. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Escuche el programa de este miércoles 27 de marzo. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Escuche el programa de este miércoles 3 de julio. La Luciérnaga, un espacio de humor y opinión de Caracol Radio que desde hace 31 años acompaña a sus oyentes en su regreso casa.

Edilberto Molina, alcalde de Cartagena del Chairá, habla de la extorsión de la que ha sido víctima en los últimos días

El antiguo secretariado de las Farc nuevamente envió una carta para criticar la labor de la JEP en medio del proceso de paz, pero esta vez no la remitieron al presidente Gustavo Petro, sino a los firmantes del Acuerdo de Paz del 2016.

Las víctimas ahora expresan preocupación ante las dudas que generan las insistencias de los exFarc para acabar con la JEP

Varios alcaldes, entre ellos Alejandro Eder enviaron una carta al presidente Petro para pedir que retome los bombardeos y elimine las restricciones para enfrentar a los grupos armados

The peptide hormone ghrelin is produced in cardiomyocytes and acts through the myocardial growth hormone secretagogue receptor (GHSR) to promote cardiomyocyte survival. Administration of ghrelin may have therapeutic effects on post–myocardial infarction (MI) outcomes. Therefore, there is a need to develop molecular imaging probes that can track the dynamics of GHSR in health and disease to better predict the effectiveness of ghrelin-based therapeutics. We designed a high-affinity GHSR ligand labeled with ¹⁸F for imaging by PET and characterized its in vivo properties in a canine model of MI. Methods: We rationally designed and radiolabeled with ¹⁸F a quinazolinone derivative ([¹⁸F]LCE470) with subnanomolar binding affinity to GHSR. We determined the sensitivity and in vivo and ex vivo specificity of [¹⁸F]LCE470 in a canine model of surgically induced MI using PET/MRI, which allowed for anatomic localization of tracer uptake and simultaneous determination of global cardiac function. Uptake of [¹⁸F]LCE470 was determined by time–activity curve and SUV analysis in 3 regions of the left ventricle—area of infarct, territory served by the left circumflex coronary artery, and remote myocardium—over a period of 1.5 y. Changes in cardiac perfusion were tracked by [¹³N]NH₃ PET. Results: The receptor binding affinity of LCE470 was measured at 0.33 nM, the highest known receptor binding affinity for a radiolabeled GHSR ligand. In vivo blocking studies in healthy hounds and ex vivo blocking studies in myocardial tissue showed the specificity of [¹⁸F]LCE470, and sensitivity was demonstrated by a positive correlation between tracer uptake and GHSR abundance. Post-MI changes in [¹⁸F]LCE470 uptake occurred independently of perfusion tracer distributions and changes in global cardiac function. We found that the regional distribution of [¹⁸F]LCE470 within the left ventricle diverged significantly within 1 d after MI and remained that way throughout the 1.5-y duration of the study. Conclusion: [¹⁸F]LCE470 is a high-affinity PET tracer that can detect changes in the regional distribution of myocardial GHSR after MI. In vivo PET molecular imaging of the global dynamics of GHSR may lead to improved GHSR-based therapeutics in the treatment of post-MI remodeling.

The final post-mortem and chemical analysis reports of playback singer Krishnakumar Kunnath, popularly known as KK, cited 'myocardial infarction' as the cause of the singer's death.

The guerrillas are handing weapons over to the UN, but they are in fear. Thomas Mortensen reports from Urabá.

The Frisky Suspenders, a farcical play, makes fun of the human weakness of jumping to conclusions

The top down approach of the Disaster Managment Act had its advantages but completely ignored local knowledge and ways of living. The need is for a judicious mix of the traditional and technological, argues Max Martin.

The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.

Acute myocardial infarction (MI) triggers a local and systemic inflammatory response. We recently showed microglia involvement using TSPO imaging. Here, we evaluate whether ¹¹C-methionine provides further insights into heart-brain inflammation networking. Methods: Male Bl6N mice underwent permanent coronary artery ligation followed by ¹¹C-methionine PET at 3 and 7 days (n = 3). In subgroups, leukocyte homing was blocked by integrin antibodies (n = 5). The cellular substrate for PET signal was identified using brain section immunostaining. Results: ¹¹C-methionine uptake peaked in the MI region at d3 (5.9±0.9vs 2.4±0.5 %ID/cc), decreasing to control level by d7 (4.3±0.6 %ID/cc). Brain uptake was proportional to cardiac uptake (r=0.47,p<0.05), peaking also at d3 (2.9±0.4vs 2.4±0.3 %ID/cc) and returning to baseline at d7 (2.3±0.4 %ID/cc). Integrin blockade reduced uptake at every time point. Immunostaining at d3 revealed co-localization of the L-type amino acid transporter with GFAP-positive astrocytes but not CD68-positive microglia. Conclusion: PET imaging with ¹¹C-methionine specifically identifies an astrocyte component, enabling further dissection of the heart-brain axis in post MI inflammation.

Naoko Sawada
Apr 14, 2020; 0:jlr.RA119000312v1-jlr.RA119000312
Research Articles

Oxidized low-density lipoprotein (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, detected by the anti-oxidized phosphatidylcholine (oxPC) monoclonal antibody, was recovered in flow-through and electronegative LDL (LDL(-)) fractions. The amount of the electronegative in vivo-oxLDL, namely oxLDL in LDL(-) fraction, present in patients with acute myocardial infarction (AMI) was three-fold higher than that observed in healthy subjects. Surprisingly, LDL(-) fraction contained apoA1 in addition to apoB, and HDL-sized particles were observed with transmission electron microscopy. In LDL(-) fractions, acrolein adducts were identified at all lysine residues in apoA1, with only a small number of acrolein-modified residues were identified in apoB. The amount of oxPC adducts of apoB was higher in LDL(-) than in L1 fraction as determined using western blotting. The electronegative in vivo-oxLDL was immunologically purified from the LDL(-) fraction with an anti-oxPC monoclonal antibody. Majority of PC species was not oxidized, whereas oxPC and lysoPC did not accumulate. Here, we propose that there are two types of in vivo-oxLDL in human circulating plasma and the electronegative in vivo-oxLDL accompanies oxidized HDL.

Type 2 diabetes mellitus predicts outcome following acute myocardial infarction (AMI). Since underlying mechanics are incompletely understood, we investigated left ventricular (LV) and atrial (LA) pathophysiological changes and their prognostic implications using cardiovascular magnetic resonance (CMR). Consecutive patients (n=1147, n=265 diabetic; n=882 non-diabetic) underwent CMR 3 days after AMI. Analyses included LV ejection fraction (LVEF), global longitudinal, circumferential and radial strains (GLS, GCS and GRS), LA reservoir, conduit and booster pump strains, as well as infarct size, edema and microvascular obstruction. Predefined endpoints were major adverse cardiovascular events (MACE) within 12 months. Diabetic patients had impaired LA reservoir (19.8 vs. 21.2%, p<0.01) and conduit strains (7.6 vs. 9.0%, p<0.01) but not ventricular function or myocardial damage. They were at higher risk of MACE than non-diabetic patients (10.2% vs. 5.8%, p<0.01) with most MACE occurring in patients with LVEF≥35%. Whilst LVEF (p=0.045) and atrial reservoir strain (p=0.024) were independent predictors of MACE in non-diabetic patients, GLS was in diabetic patients (p=0.010). Considering patients with diabetes and LVEF≥35% (n=237), GLS and LA reservoir strain below median were significantly associated with MACE. In conclusion, in patients with diabetes, LA and LV longitudinal strain permit optimized risk assessment early after reperfused AMI with incremental prognostic value over and above LVEF.

OBJECTIVE

To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post–myocardial infarction (MI) patients.

John J O'Sullivan
Aug 1, 1991; 14:758-760
Short Report

OBJECTIVE

We sought to determine the prevalence of diabetes and associated cardiovascular outcomes in a contemporary cohort of young individuals presenting with their first myocardial infarction (MI) at age ≤50 years.

OBJECTIVE

Patients with diabetes mellitus (DM) have elevated levels of high-sensitivity cardiac troponin (hs-cTn). We investigated the diagnostic performance of the European Society of Cardiology (ESC) algorithms to rule out or rule in acute myocardial infarction (AMI) without ST-elevation in patients with DM.

Liverpool mayor Joe Anderson has described plans to resume the Premier League season as a 'non-starter', sharing his fear that 'farcical' scenes would ensue in the event of the title heading to Merseyside.

A 32-year-old Colombian citizen, Luz Mery Gutierrez Vergara, who was extradited from the Republic of Colombia on Thursday, made her initial appearance today in federal court in Washington, D.C., to face charges for allegedly participating in a conspiracy to provide material support to the Fuerzas Armadas Revolucionarias de Colombia, commonly known as the “FARC.”

Tanja Anamary Nijmeijer, a Dutch national who moved to Colombia and joined the Revolutionary Armed Forces of Colombia (FARC) in 2002, and 17 other members of the FARC designated foreign terrorist organization were indicted by a federal grand jury in Washington, D.C., today on seven counts of terrorism and weapons charges arising out of their participation in the hostage-taking of three American citizens in the Republic of Colombia.

Alexander Beltran Herrera, 37, a commander of the FARC terrorist organization, pleaded guilty today in the U.S. District Court for the District of Columbia to hostage-taking charges stemming from the 2003 kidnappings of three U.S. citizens in Colombia.

Highights: Mussels help in treating myocardial infarction (MI) A protein from mussels and stem cells help t

Slapstick; sexual jealousy; and mistaken identity. At its best, farce can be sublime – its intricate plotting and sheer silliness combining to blissful comic effect. But should we take farce seriously, or is is mere lowbrow entertainment? What makes a good farce, and how should a director approach it? On the opening of Georges Feydeau’s 1907 farce 'A Flea in Her Ear' at the Old Vic in London, Jan Dalley puts these questions to its distinguished director, Sir Richard Eyre, who was artistic director of the National Theatre for a decade, and to Sarah Hemming, the FT's theatre critic. Produced by Griselda Murray Brown.  

See acast.com/privacy for privacy and opt-out information.

In the controversial doc which aired on HBO earlier this year, two men made specific claims about being sexually molested as kids by the late Thriller singer; Jackson's estate has denied their accusations.