London — Workers who experience depression may be less prone to miss work when managers show greater sensitivity to their mental health and well-being, recent research from the London School of Economics and Political Science shows.

Boston – More than 1 out of 8 commercial airline pilots meet the criteria for clinical depression, and a small percentage have suicidal thoughts, according to a study from the Harvard T.H. Chan School of Public Health.

The post Antidepressant Adherence for Depressed Adults in Primary Care was curated by information for practice.

Al Gore, Founder and Chairman of The Climate Reality Project on Trump winning: “In a moment such as this, it is important to remember that all major reform efforts, from civil rights to the climate movement, suffer dark days. And this is surely one.” Via Gore’s email list on November 6, 2024  

Climate Depot note: I will be on the ground again this year attending the UN climate summit COP29 in Azerbaijan. Morano will be there for the week of November 10th through 15 in Baku, following the UN’s every effort to squelch your freedom and continue the dark path of net-zero rationing of energy, food, freedom of […]

The bias may make it harder for depressed and anxious people to take a risk on a new relationship, job or other career opportunity.

Patients with arthritis report using cannabis for pain management, and the major cannabinoid delta-9-tetrahydrocannabinol (⁹-THC) has anti-inflammatory properties, yet the effects of minor cannabinoids on arthritis are largely unknown. The goal of the present study was to determine the antiarthritic potential of the minor cannabinoid delta-8-tetrahydrocannabinol (⁸-THC) using the collagen-induced arthritis (CIA) mouse model. Adult male DBA/1J mice were immunized and boosted 21 days later with an emulsion of collagen and complete Freund’s adjuvant. Beginning on the day of the booster, mice were administered twice-daily injections of ⁸-THC (3 or 30 mg/kg), the steroid dexamethasone (2 mg/kg), or vehicle for two weeks. Dorsal-ventral paw thickness and qualitative measures of arthritis were recorded daily, and latency to fall from an inverted grid was measured on alternating days, to determine arthritis severity and functional impairment. On the final day of testing, spontaneous wire-climbing behavior and temperature preference in a thermal gradient ring were measured to assess CIA-depressed behavior. The ⁸-THC treatment (30 mg/kg) reduced paw swelling and qualitative signs of arthritis. ⁸-THC also blocked CIA-depressed climbing and CIA-induced preference for a heated floor without producing locomotor effects but did not affect latency to fall from a wire grid. In alignment with the morphologic and behavioral assessments in vivo, histology revealed that ⁸-THC reduced synovial inflammation, proteoglycan loss and cartilage and bone erosion in the foot joints in a dose-dependent manner. Together, these findings suggest that ⁸-THC not only blocked morphologic changes but also prevented functional loss caused by collagen-induced arthritis.

Low-efficacy mu opioid receptor (MOR) agonists may serve as novel candidate analgesics with improved safety relative to high-efficacy opioids. This study used a recently validated assay of pain-depressed behavior in mice to evaluate a novel series of MOR-selective C9-substituted phenylmorphan opioids with graded MOR efficacies. Intraperitoneal injection of dilute lactic acid (IP acid) served as a noxious stimulus to depress locomotor activity by mice in an activity chamber composed of two compartments connected by an obstructed door. Behavioral measures included (1) crosses between compartments (vertical activity over the obstruction) and (2) movement counts quantified as photobeam breaks summed across compartments (horizontal activity). Each drug was tested alone and as a pretreatment to IP acid. A charcoal-meal test and whole-body-plethysmography assessment of breathing in 5% CO₂ were also used to assess gastrointestinal (GI) inhibition and respiratory depression, respectively. IP acid produced a concentration-dependent depression in crosses and movement that was optimally alleviated by intermediate- to low-efficacy phenylmorphans with sufficient efficacy to produce analgesia with minimal locomotor disruption. Follow-up studies with two low-efficacy phenylmorphans (JL-2-39 and DC-1-76.1) indicated that both drugs produced naltrexone-reversible antinociception with a rapid onset and a duration of ~1 h. Potency of both drugs increased when behavior was depressed by a lower IP-acid concentration, and neither drug alleviated behavioral depression by a non-pain stimulus (IP lithium chloride). Both drugs produced weaker GI inhibition and respiratory depression than fentanyl and attenuated fentanyl-induced GI inhibition and respiratory depression. Results support further consideration of selective, low-efficacy MOR agonists as candidate analgesics.

Bade Achhe Lagte Hain fame Chahatt Khanna is a single mother with two beautiful girls, Zohar and Amaira. Recently, the actress lashed out at online trolls criticising her for being a single mother. She shared a few notes on her Instagram

He's interviewed Neko Case, Jeff Tweedy and Maria Bamford about depression. With his new memoir, "The Hilarious World of Depression," John Moe looks inward.

Depression is one of the most common mental health issues in the United States. In fact, according to the National Institutes of Mental Health, 1 in 14 Americans experienced an episode of major depression in the last year alone. Given the circumstances surrounding the current COVID-19 coronavirus pandemic, many in the mental health community predict that the number will be even higher this year because these circumstances are creating a “perfect storm” of depression risks. The widespread prevalence of depression has a lot of implications for our lives, even if we don’t personally have depression ourselves. Many of us will have loved ones, such as a romantic partner, who develops depression at some point. In these situations, it’s common for people to wonder how they can help their partner most effectively. So what should they do?

Title: Deep Brain Stimulation Helps Severely Depressed
Category: Health News
Created: 4/29/2008 2:00:00 AM
Last Editorial Review: 4/29/2008 12:00:00 AM

Title: Depressed Pregnant Women 3 Times More Likely to Turn to Pot
Category: Health News
Created: 3/12/2020 12:00:00 AM
Last Editorial Review: 3/13/2020 12:00:00 AM

As sheltering in place stretches into weeks for many, anxiety, isolation, stress and cabin fever are common. There's free mental health help online.

A new survey by GfK found there was a slight overall improvement in mood but fears for the future remain.

A new report has found climate change is having some unexpected consequences for people living in the Asia Pacific region.

Various healthy diets are shown to ease symptoms of depression, and they work even better for women.

The company reiterated that its dividend is a priority, and that it's taking action to sustain it over the long term.