At one of my first meetings as an elected council member of the Royal College of Surgeons of England, we approved a report called Access All Ages. It encouraged less ageist thinking and bias among healthcare staff that might lead to them denying older people surgery.1 But sometimes an operation isn’t the best option. Among patients who have surgery, 14% express regret and 15% experience complications, which are at least four times as likely if they’re frail or physically inactive.2 The Centre for Perioperative Care has published information on the importance of exercise before surgery,3 but that alone may not be enough.We need shared decision making,4 including asking patients what matters to them. The public should be primed to ask about BRAN—the benefits, risks, and alternatives to surgery and the likely result from doing nothing.4 A slew of data supports this approach, especially from the POPS initiative (Perioperative Care of...

Offers study guides of all leading certifications includes MCSE, MCSD, MCSA, Oracle 8i, Oracle 9i, CCNA, CCNP and A+.

The SMACNA Board of Directors welcomed Tom Martin, president of Cleveland-based T.H. Martin, Inc., as its 2024-2025 president. Martin took the reins from current SMACNA president Carol Duncan of General Sheet Metal.

The TCNA Handbook for Ceramic, Glass, and Stone Tile Installation is scheduled to be released in April.

Dr. Carnes-McNaughton is an accomplished scholar and archaeologist with the Fort Bragg Cultural Resources Management Program

Taurino TJ Trevino is a respected logistics professional and dedicated civic servant

International manufacturer of electric vehicle components plans to invest $94.7 million in a 333,000-square-foot facility in New Century, Kansas.

Tim McNamara, author of Rust in Action, discusses the top three benefits of Rust and why they make it a performant, reliable and productive programming language.

Tune into Gabe Rivas’s most recent course release, Network Foundation Protection: Management Plane, the second in a series of eight CCNA security courses. Network Foundation Protection is a security framework that provides with strategies to protect three functional areas of a device: Management Plane, Control Plane, and Data plane. In this Course we will focus [...]

Maybe it's a genuine sentiment. Maybe it's clouded by bitterness stemming from his one (failed) season in Washington. Regardless, former Redskins quarterback Donovan McNabb is not a fan of the zone read option.

Un intruso llamado ‘Recnac’

Jonathan C. Trinidad
Aug 1, 2012; 11:215-229
Research

Stromal interaction molecule 1 (STIM1) plays a pivotal role in store-operated Ca2+ entry (SOCE), an essential mechanism in cellular calcium signaling and in maintaining cellular calcium balance. Because O-GlcNAcylation plays pivotal roles in various cellular function, we examined the effect of fluctuation in STIM1 O-GlcNAcylation on SOCE activity. We found that both increase and decrease in STIM1 O-GlcNAcylation impaired SOCE activity. To determine the molecular basis, we established STIM1-knockout HEK293 (STIM1-KO-HEK) cells using the CRISPR/Cas9 system and transfected STIM1 WT (STIM1-KO-WT-HEK), S621A (STIM1-KO-S621A-HEK), or T626A (STIM1-KO-T626A-HEK) cells. Using these cells, we examined the possible O-GlcNAcylation sites of STIM1 to determine whether the sites were O-GlcNAcylated. Co-immunoprecipitation analysis revealed that Ser621 and Thr626 were O-GlcNAcylated and that Thr626 was O-GlcNAcylated in the steady state but Ser621 was not. The SOCE activity in STIM1-KO-S621A-HEK and STIM1-KO-T626A-HEK cells was lower than that in STIM1-KO-WT-HEK cells because of reduced phosphorylation at Ser621. Treatment with the O-GlcNAcase inhibitor Thiamet G or O-GlcNAc transferase (OGT) transfection, which increases O-GlcNAcylation, reduced SOCE activity, whereas treatment with the OGT inhibitor ST045849 or siOGT transfection, which decreases O-GlcNAcylation, also reduced SOCE activity. Decrease in SOCE activity due to increase and decrease in O-GlcNAcylation was attributable to reduced phosphorylation at Ser621. These data suggest that both decrease in O-GlcNAcylation at Thr626 and increase in O-GlcNAcylation at Ser621 in STIM1 lead to impairment of SOCE activity through decrease in Ser621 phosphorylation. Targeting STIM1 O-GlcNAcylation could provide a promising treatment option for the related diseases, such as neurodegenerative diseases.

Manchester : Manchester University Press, [2018]

London : SAGE, ©2001.

Shaking up insurance: C-Quence founder Jacqueline McNamee tells Insurance Age why she broke out of a career in big corporates and why technology is poised to disrupt the industry

Dr. McNair utilizes her medical expertise as a general practitioner as well as in LGBT activism

Society for Advancement of Chicanos/Hispanics & Native Americans in Science announces innovative leader to take the helm of the country's largest multicultural and multidisciplinary STEM diversity organization.

Astronaut, leader & role model to keynote nation's largest multicultural & multidisciplinary STEM diversity conference

Miss Jacobs has been endorsed by Marquis Who's Who as a leader in the field of nursing

The Corporate Whistleblower Center is dramatically expanding their nationwide initiative to identify healthcare workers who are employed at facilities like nursing homes who have proof of extreme short staffing-it's a multi-billion dollar problem.

The Corporate Whistleblower Center is now urging a CNA, LPN or a RN at a nursing home or a skilled nursing facility that is constantly short staffed to call them-if the owner of the facility is billing Medicaid as if they are fully staffed.

Expanding Commitment to Sound Telemedicine Service Offering

The Corporate Whistleblower Center is an advocate for taxpayers, healthcare workers and patients and they are extremely worried the Coronavirus will explode in our nation's nursing homes and long term care facilities-because many are short staffed.

Two men have been ordered to stand trial over the murder of Wangaratta man Nathan Day, with a Victorian court hearing evidence from dozens of witnesses during a week-long committal hearing.

(United States Fifth Circuit) - Held that a Houston law firm should be allowed to intervene in a lawsuit to protect its right to a contingent fee. The firm's client and the opposing party had allegedly conspired to cheat it out of its deserved attorney fee for work on a matter involving a foreign arbitral award. Remanded with directions to permit intervention and consider the law firm's claims on the merits.

(United States Fifth Circuit) - Held that a Houston law firm should be allowed to intervene in a lawsuit to protect its right to a contingent fee. The firm's client and the opposing party had allegedly conspired to cheat it out of its deserved attorney fee for work on a matter involving a foreign arbitral award. Remanded with directions to permit intervention and consider the law firm's claims on the merits.

Mary McNamara, who won a Pulitzer Prize in 2015 for her television criticism, has been named The Times' assistant managing editor for arts and entertainment. 

Terrence McNally, whose varied and prolific career as a playwright, musical librettist and screenwriter earned him five Tony Awards and an Emmy, died Tuesday.

I've spent 20 years covering the Oscars, and yes, they're splendid and ridiculous, flawed and inspirational. That's why they still matter.

Rangers could be without Alfredo Morelos and Scott Arfield for their trip to play Hearts on Sunday.

Jonathan C. Trinidad
Aug 1, 2012; 11:215-229
Research

FORMER NATIONAL footballer Aldrick ‘Allie’ McNab is concerned about the effect of the COVID-19 pandemic on the Caribbean’s football development. The coronavirus has caused the postponement, suspension, and cancellation of a number of sporting...

Below I share some details about SACNAS and some of the mathematical events that happened at this year’s SACNAS National Conference.  I hope that this may also serve as an invitation/motivation for anyone interested in diversity and mathematics to participate … Continue reading →

Music Division Archivist Morgen Stevens-Garmon reflects upon American playwright, screenwriter, and librettist Terrence McNally, who died of complications due to COVID-19 on March 24, 2020.

The disgraced cross-code star has already proved the most contentious signing in the competition's 25-year history after joining the Dragons on a one-year deal.

She has played the role of Tori Morgan on Home and Away since 2016. 

Paddy McNair is hoping Holland underestimate Northern Ireland in their Euro 2020 qualifier in Rotterdam. Northern Ireland need to win in order to keep their dreams of reaching the finals alive.

It's been 10 years since veteran entertainment reporter Richard Wilkins made a most notorious on-air blunder that could have almost ended his career. 

She relocated their family from England back to Australia in April. 

Paddy McNair is hoping Holland underestimate Northern Ireland in their Euro 2020 qualifier in Rotterdam. Northern Ireland need to win in order to keep their dreams of reaching the finals alive.

True-crime author Michelle McNamara died of an accidental overdose on April 21, 2016 - just two years before police arrested Joseph James DeAngelo, the suspected Golden State Killer.

[London] : [Published by the National Union of Women's Suffrage Societies, 25, Victoria Street, Westminster, S.W.], [November, 1908]

Cham, Switzerland : Palgrave Macmillan, [2019]