RainStick Shower co-founders Alisha McFetridge and Sean McFetridge share a longtime passion for water conservation. In 2019, the two began building the North American Market’s first water circulating shower. Supply House Times Chief Editor Natalie Forster sat down with Alisha McFetridge to dive into RainStick Shower’s backstory and plans for the future.

Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank  Nature.com

SAGE Publications

Ball screws are described that may be incorporated into other devices such as a pulley assembly or a differential device. The ball screws include a threaded shaft defining a central longitudinal axis with a threaded nut threadedly coupled thereto to define at least one track in between them. Each track forms a continuous loop around an infield protrusion and is filled with a plurality of rolling elements filling. Each rolling element has the same radius from the central longitudinal axis such that the nut can rotate at higher speeds without the rolling elements locking up as a result of centripetal force.

A novel 3-Input-3-Output (3×3) Fuel-Air Ratio Model-Free Adaptive (MFA) controller is introduced, which can effectively control key process variables including Bed Temperature, Excess O2, and Furnace Negative Pressure of combustion processes of advanced boilers. A novel 7-input-7-output (7×7) MFA control system is also described for controlling a combined 3-Input-3-Output (3×3) process of Boiler-Turbine-Generator (BTG) units and a 5×5 CFB combustion process of advanced boilers. Those boilers include Circulating Fluidized-Bed (CFB) Boilers and Once-Through Supercritical Circulating Fluidized-Bed (OTSC CFB) Boilers.

A circulating fluidized bed boiler includes a rectangular furnace having multiple particle separators connected to an upper portion of each of a front wall and a back wall of the furnace. Each particle separator includes a gas outlet, and a flue gas duct system connected to the gas outlets for conducting cleaned flue gas to a back pass. The particle separators are arranged in pairs. Each pair includes a front separator arranged adjacent to the front wall and a back separator arranged adjacent to the back wall. The flue gas duct system includes cross over ducts, each duct connecting the gas outlet of a front separator of a pair of particle separators, across and over the furnace, to the gas outlet of the back separator of the same pair of particle separators, and to the back pass, which back pass is arranged on the back wall side of the furnace.

An evaporator surface structure of a circulating fluidized bed boiler having a furnace that is enclosed by sidewalls and has a bottom and a ceiling. The evaporator surface structure includes at least one vertical and separate evaporator surface unit that is spaced apart from the sidewalls of the furnace. The at least one evaporator surface unit (i) is formed of planar water tube panels that extend from the bottom of the furnace to the ceiling of the furnace, and (ii) consists of two cross-wise joined vertical water tube panels.

An improved scraper plate assembly is provided on a comminuting device having compliant rounded edges, sloped walls, and reduced height for placement along recycle flow paths within a comminuting apparatus when circulating subdivided waste material from between a pair of scissor rolls for further delivery to a scissor roll for further movement and subdividing of the subdivided waste material. A comminuting apparatus is also provided.

A dispensing unit is provided having a circulation system for circulating a fluid in the dispensing unit. The circulation system includes a circulation circuit and a mechanism for circulating the fluid in the circulation circuit. By circulating the fluid, the fluid is counteracted from crystallizing. A method for circulating a fluid in a dispensing unit is also provided.

A heat transfer device including a container in which a heat-transfer fluid circulates in a closed loop. The heat transfer fluid is capable of undergoing an increase in volume on solidifying. The container further contains particles suspended in the heat-transfer fluid. At least some of the particles are compressible under the pressure of the fluid, as the fluid is solidifying, so as to at least partially compensate for the increase in volume of the fluid upon solidifying.

Businesses in SA's Riverland are urged to be on the lookout for fake $100 notes after one was passed at a bakery and two other incidents were reported to police.

Naoko Sawada
Apr 14, 2020; 0:jlr.RA119000312v1-jlr.RA119000312
Research Articles

Oxidized low-density lipoprotein (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, detected by the anti-oxidized phosphatidylcholine (oxPC) monoclonal antibody, was recovered in flow-through and electronegative LDL (LDL(-)) fractions. The amount of the electronegative in vivo-oxLDL, namely oxLDL in LDL(-) fraction, present in patients with acute myocardial infarction (AMI) was three-fold higher than that observed in healthy subjects. Surprisingly, LDL(-) fraction contained apoA1 in addition to apoB, and HDL-sized particles were observed with transmission electron microscopy. In LDL(-) fractions, acrolein adducts were identified at all lysine residues in apoA1, with only a small number of acrolein-modified residues were identified in apoB. The amount of oxPC adducts of apoB was higher in LDL(-) than in L1 fraction as determined using western blotting. The electronegative in vivo-oxLDL was immunologically purified from the LDL(-) fraction with an anti-oxPC monoclonal antibody. Majority of PC species was not oxidized, whereas oxPC and lysoPC did not accumulate. Here, we propose that there are two types of in vivo-oxLDL in human circulating plasma and the electronegative in vivo-oxLDL accompanies oxidized HDL.

The increasing prevalence of type 2 diabetes poses a major challenge to societies worldwide. Blood-based factors like serum proteins are in contact with every organ in the body to mediate global homeostasis and may thus directly regulate complex processes such as aging and the development of common chronic diseases. We applied a data-driven proteomics approach, measuring serum levels of 4,137 proteins in 5,438 elderly Icelanders and identified 536 proteins associated with prevalent and/or incident type 2 diabetes. We validated a subset of the observed associations in an independent case-control study of type 2 diabetes. These protein associations provide novel biological insights into the molecular mechanisms that are dysregulated prior to and following the onset of type 2 diabetes and can be detected in serum. A bi-directional two-sample Mendelian randomization analysis indicated that serum changes of at least 23 proteins are downstream of the disease or its genetic liability, while 15 proteins were supported as having a causal role in type 2 diabetes.

OBJECTIVE

In patients with type 2 diabetes (T2D) and critical limb ischemia (CLI), migration of circulating CD34⁺ cells predicted cardiovascular mortality at 18 months after revascularization. This study aimed to provide long-term validation and mechanistic understanding of the biomarker.

OBJECTIVE

The aim of this study was to examine the association of circulating retinol-binding protein 4 (RBP4) levels with β-cell function across the spectrum of glucose tolerance from normal to overt type 2 diabetes.

Background:

Sex steroid hormones and sex hormone–binding globulin (SHBG) have been implicated in the etiology of invasive breast cancer, but their associations with risk of the precursor lesion, ductal carcinoma in situ (DCIS) of the breast, remain unclear.

Background:

Pancreatic cancer is the third leading cause of cancer death in the United States, and 80% of patients present with advanced, incurable disease. Risk markers for pancreatic cancer have been characterized, but combined models are not used clinically to identify individuals at high risk for the disease.

Background:

Visceral adipose tissue (VAT) may play a greater role than subcutaneous fat in increasing cancer risk but is poorly estimated in epidemiologic studies.

Although ample evidence indicates that immune cell homeostasis is an important prognostic outcome determinant in patients with cancer, few studies have examined whether it also determines cancer risk among initially healthy individuals. We performed a case–cohort study including incident cases of breast (n = 207), colorectal (n = 111), lung (n = 70), and prostate (n = 201) cancer as well as a subcohort (n = 465) within the European Prospective Investigation into Cancer and Nutrition-Heidelberg cohort. Relative counts of neutrophils, monocytes, and lymphocyte sublineages were measured by qRT-PCR. HRs and 95% confidence intervals were used to measure the associations between relative counts of immune cell and cancer risks. When relative counts of immune cell types were taken individually, a significant positive association was observed between relative counts of FOXP3+ regulatory T cells (Tregs) and lung cancer risk, and significant inverse associations were observed between relative CD8+ counts and risks of lung and breast cancer (overall and ER+ subtype). Multivariable models with mutual adjustments across immune markers showed further significant positive associations between higher relative FOXP3+ T-cell counts and increased risks of colorectal and breast cancer (overall and ER− subtype). No associations were found between immune cell composition and prostate cancer risk. These results affirm the relevance of elevated FOXP3+ Tregs and lower levels of cytotoxic (CD8+) T cells as risk factors for tumor development.Significance:This epidemiologic study supports a role for both regulatory and cytotoxic T cells in determining cancer risk among healthy individuals.See related commentary by Song and Tworoger, p. 1801

Image credit: UMBI Center of Marine Biotechnology Fully Contained, Indoor Fish Farming Update: Karin has reported on this initiative before under Fish Farming Moves to the Condos, and Lloyd also covered it under the Future of Food. Great to see it still

It is a real problem when designing energy efficient homes, and it seems that there is no good solution except ordering in.

Almost every American office building and home has this.

Cases of coronavirus in Florida have surged to nearly 7,000, with 857 people hospitalized and 87 dead. The first confirmed case of coronavirus in Florida was a month after the Superbowl on March 1.

Interview with Jeanne Tie, author of Prognostic Potential of Circulating Tumor DNA Measurement in Postoperative Surveillance of Nonmetastatic Colorectal Cancer