A third of the more than 300 million electrocardiograms (EKGs) conducted annually worldwide are performed in the United States. The technology behind

Learn how the innovative wireless EKG patch matches or exceeds traditional EKG accuracy, offering improved ease of use and reducing errors.

Berlin-based x-cardiac GmbH is pleased to announce that Freiburg University Hospital has become the second pilot customer for its AI-based software "x-c-bleeding" for predicting severe bleeding complications after cardiac surgery. With the implementation of "x-c-bleeding", the University Hospital Freiburg takes another important step towards AI-based medicine.

Dallas – More people are able to return to work after suffering cardiac arrest thanks in part to an increased number of bystanders performing CPR, researchers conclude in a new Danish study.

Boston – Chasing and restraining suspects, in addition to other chaotic encounters, puts police officers at an approximately 30 percent to 70 percent higher risk of sudden cardiac death, suggests a new study from the Harvard School of Public Health and Cambridge Health Alliance.

Gaithersburg, MD — Recently developed artificial intelligence software can determine whether firefighters may be about to experience a potentially fatal cardiac event, researchers say.

Cardiac arrest strikes almost 600,000 people each year, killing the vast majority of those individuals, says a new report from the Institute of Medicine. Every year in the U.S., approximately 395,000 cases of cardiac arrest occur outside of a hospital setting, in which less than 6 percent survive.

An accomplished physician, scholar and educator, Saroja Bharati has secured a distinguished reputation in the healthcare industry

Dr. John Tejeda lends years of expertise to his work with Perspective Health Partners

Healthcare workload has emerged as an important metric associated with poor outcomes. To measure workload, studies have used bed occupancy as a surrogate. However, few studies have examined frontline clinician workload and outcomes.

WASHINGTON, D.C., March 20, 2024 — The U.S. House of Representatives’ Energy and Commerce Committee today is considering the Cardiomyopathy Health Education, Awareness, Research and Training in Schools (HEARTS) Act, which would help ensure students ...

WASHINGTON, D.C., September 23, 2024 — The U.S. House of Representatives today passed the Cardiomyopathy Health Education, Awareness, Research and Training in Schools (HEARTS) Act, which would help ensure students, staff and school visitors are prepared...

DALLAS, January 3, 2023 —While playing in the Buffalo Bills - Cincinnati Bengals game on Monday Night Football on January 2, Bills player Damar Hamlin suffered a cardiac arrest after a hit and was administered CPR on the field before being transferred to...

This news release contains updated information and data not included in the abstract. Research Highlights: U.S. survival rates from out-of-hospital cardiac arrests fell significantly at the beginning of the COVID-19 pandemic in 2020 and only slightly ...

This news release contains updated information and data not included in the abstract. Research Highlights: The sooner a lay rescuer (bystander) starts cardiopulmonary resuscitation (CPR) on a person having a cardiac arrest at home or in public, up to ...

Updated Guideline Highlights: The American Heart Association and the American Academy of Pediatrics update recommendations for untrained lay rescuers and trained rescuers resuscitating adults and children who have drowned. One important update is the ...

Cardiac profile from the medical history summary of President George W. Bush, August 7, 2007.

The QT interval is a recording of cardiac electrical activity. Previous genome-wide association studies identified genetic variants that modify the QT interval upstream of LITAF (lipopolysaccharide-induced tumor necrosis factor-α factor), a protein encoding a regulator of endosomal trafficking. However, it was not clear how LITAF might impact cardiac excitation. We investigated the effect of LITAF on the voltage-gated sodium channel Nav1.5, which is critical for cardiac depolarization. We show that overexpressed LITAF resulted in a significant increase in the density of Nav1.5-generated voltage-gated sodium current INa and Nav1.5 surface protein levels in rabbit cardiomyocytes and in HEK cells stably expressing Nav1.5. Proximity ligation assays showed co-localization of endogenous LITAF and Nav1.5 in cardiomyocytes, whereas co-immunoprecipitations confirmed they are in the same complex when overexpressed in HEK cells. In vitro data suggest that LITAF interacts with the ubiquitin ligase NEDD4-2, a regulator of Nav1.5. LITAF overexpression down-regulated NEDD4-2 in cardiomyocytes and HEK cells. In HEK cells, LITAF increased ubiquitination and proteasomal degradation of co-expressed NEDD4-2 and significantly blunted the negative effect of NEDD4-2 on INa. We conclude that LITAF controls cardiac excitability by promoting degradation of NEDD4-2, which is essential for removal of surface Nav1.5. LITAF-knockout zebrafish showed increased variation in and a nonsignificant 15% prolongation of action potential duration. Computer simulations using a rabbit-cardiomyocyte model demonstrated that changes in Ca2+ and Na+ homeostasis are responsible for the surprisingly modest action potential duration shortening. These computational data thus corroborate findings from several genome-wide association studies that associated LITAF with QT interval variation.

AMP-activated protein kinase (AMPK) is a key regulator of energy metabolism that phosphorylates a wide range of proteins to maintain cellular homeostasis. AMPK consists of three subunits: α, β, and γ. AMPKα and β are encoded by two genes, the γ subunit by three genes, all of which are expressed in a tissue-specific manner. It is not fully understood, whether individual isoforms have different functions. Using RNA-Seq technology, we provide evidence that the loss of AMPKβ1 and AMPKβ2 lead to different gene expression profiles in human induced pluripotent stem cells (hiPSCs), indicating isoform-specific function. The knockout of AMPKβ2 was associated with a higher number of differentially regulated genes than the deletion of AMPKβ1, suggesting that AMPKβ2 has a more comprehensive impact on the transcriptome. Bioinformatics analysis identified cell differentiation as one biological function being specifically associated with AMPKβ2. Correspondingly, the two isoforms differentially affected lineage decision toward a cardiac cell fate. Although the lack of PRKAB1 impacted differentiation into cardiomyocytes only at late stages of cardiac maturation, the availability of PRKAB2 was indispensable for mesoderm specification as shown by gene expression analysis and histochemical staining for cardiac lineage markers such as cTnT, GATA4, and NKX2.5. Ultimately, the lack of AMPKβ1 impairs, whereas deficiency of AMPKβ2 abrogates differentiation into cardiomyocytes. Finally, we demonstrate that AMPK affects cellular physiology by engaging in the regulation of hiPSC transcription in an isoform-specific manner, providing the basis for further investigations elucidating the role of dedicated AMPK subunits in the modulation of gene expression.

Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of proteolysis are debated. Identification of the N and C termini of LC fragments is instrumental to understanding involved processes and enzymes. We investigated the N and C terminome of the LC proteoforms in fibrils extracted from the hearts of two AL cardiomyopathy patients, using a proteomic approach based on derivatization of N- and C-terminal residues, followed by mapping of fragmentation sites on the structures of native and fibrillar relevant LCs. We provide the first high-specificity map of proteolytic cleavages in natural AL amyloid. Proteolysis occurs both on the LC variable and constant domains, generating a complex fragmentation pattern. The structural analysis indicates extensive remodeling by multiple proteases, largely taking place on poorly folded regions of the fibril surfaces. This study adds novel important knowledge on amyloid LC processing: although our data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils.

As evidence mounts that the cardiac-sympathetic nervous system reacts to challenging cognitive settings, we ask if these responses are epiphenomenal companions or if there is evidence suggesting a more intertwined role of this system with cognitive function. Healthy male and female human participants performed an approach-avoidance paradigm, trading off monetary reward for painful electric shock, while we recorded simultaneous electroencephalographic and cardiac-sympathetic signals. Participants were reward sensitive but also experienced approach-avoidance "conflict" when the subjective appeal of the reward was near equivalent to the revulsion of the cost. Drift-diffusion model parameters suggested that participants managed conflict in part by integrating larger volumes of evidence into choices (wider decision boundaries). Late alpha-band (neural) dynamics were consistent with widening decision boundaries serving to combat reward sensitivity and spread attention more fairly to all dimensions of available information. Independently, wider boundaries were also associated with cardiac "contractility" (an index of sympathetically mediated positive inotropy). We also saw evidence of conflict-specific "collaboration" between the neural and cardiac-sympathetic signals. In states of high conflict, the alignment (i.e., product) of alpha dynamics and contractility were associated with a further widening of the boundary, independent of either signal's singular association. Cross-trial coherence analyses provided additional evidence that the autonomic systems controlling cardiac-sympathetics might influence the assessment of information streams during conflict by disrupting or overriding reward processing. We conclude that cardiac-sympathetic control might play a critical role, in collaboration with cognitive processes, during the approach-avoidance conflict in humans.

Cardiac MRI of an animal that has undergone photosynthetic therapy. CREDIT: Stanford University School of Medicine, Department of Cardiothoracic Surgery

Title: Survival More Likely With Exercise-Related Cardiac Arrest: Study
Category: Health News
Created: 8/30/2012 6:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Title: Newer Breathing Tube Might Save More Cardiac Arrest Patients
Category: Health News
Created: 8/29/2018 12:00:00 AM
Last Editorial Review: 8/30/2018 12:00:00 AM

Title: Not So Sudden: Many Seek Medical Help 2 Weeks Before Cardiac Arrest
Category: Health News
Created: 8/25/2020 12:00:00 AM
Last Editorial Review: 8/25/2020 12:00:00 AM

Title: Rising Number of U.S. Cardiac Arrests Tied to Opioid Abuse
Category: Health News
Created: 8/23/2021 12:00:00 AM
Last Editorial Review: 8/24/2021 12:00:00 AM

Neuroendocrine tumor (NET) metastases to the heart are found in 1%–4% of NET patients and have been reported primarily in the form of individual cases. We investigated the prevalence, clinical characteristics, imaging features, and outcomes of NET patients with cardiac metastases on ⁶⁸Ga-DOTATATE PET/CT. Methods: ⁶⁸Ga-DOTATATE PET/CT of 490 consecutive patients from a single institution were retrospectively reviewed for sites of metastases. The cumulative cardiovascular event rate and overall survival of patients with cardiac NET metastases (CNMs) were compared with those of a control group of metastatic NET patients without cardiac metastases. In patients with CNMs, the cardiac SUV_max with and without normalization to the myocardial background uptake was compared with a separate cohort of 11 patients with active cardiac sarcoidosis who underwent ⁶⁸Ga-DOTATATE PET/CT for research purposes. Results: In total, 270 patients with metastatic NETs were identified, 9 (3.3%) of whom had CNMs. All 9 patients had grade 1–2 gastroenteropancreatic NETs, most commonly from the small intestine (7 patients). The control group consisted of 140 patients with metastatic grade 1–2 gastroenteropancreatic NETs. On Kaplan–Meier analysis, there was no significant difference in the risk of cardiovascular adverse events (P = 0.91 on log-rank test) or mortality (P = 0.83) between the metastatic NET patients with and without cardiac metastases. The degree of cardiac DOTATATE uptake was significantly higher in CNMs than in patients with cardiac sarcoidosis without overlap, in terms of both cardiac SUV_max (P = 0.027) and SUV_max–to–myocardial background ratio (P = 0.021). Conclusion: Routine ⁶⁸Ga-DOTATATE PET/CT can be used to identify CNMs in 3% of patients with metastatic NETs. CNMs do not confer added cardiovascular or mortality risk. A distinguishing feature of CNMs is their high degree of DOTATATE uptake compared with focal myocardial inflammation.

Alveolar capillary dysplasia (ACD) is a fatal disorder that typically presents in the neonatal period with refractory hypoxemia and pulmonary hypertension. Lung biopsy is traditionally required to establish the diagnosis. We report a 22-mo-old male who presented with anemia, severe pulmonary hypertension, and right heart failure. He had a complicated hospital course resulting in cardiac arrest and requirement for extracorporeal membrane oxygenation. Computed tomography of the chest showed a heterogenous pattern of interlobular septal thickening and pulmonary edema. The etiology of his condition was unknown, lung biopsy was contraindicated because of his medical fragility, and discussions were held to move to palliative care. Rapid whole-genome sequencing (rWGS) was performed. In 2 d it resulted, revealing a novel FOXF1 gene pathogenic variant that led to the presumptive diagnosis of atypical ACD. Cases of atypical ACD have been reported with survival in patients using medical therapy or lung transplantation. Based on the rWGS diagnosis and more favorable potential of atypical ACD, aggressive medical treatment was pursued. The patient was discharged home after 67 d in the hospital; he is currently doing well more than 30 mo after his initial presentation with only one subsequent hospitalization and no requirement for lung transplantation. Our case reveals the potential for use of rWGS in a critically ill child in which the diagnosis is unknown. rWGS and other advanced genetic tests can guide clinical management and expand our understanding of atypical ACD and other conditions.

We still don’t know what COVID-19 is doing to the heart or how we should be investigating it and treating it. Last month JAMA Cardiology published a German cohort study of 100 patients recently recovered from COVID-19… A number of striking problems with the study were noted on Twitter…...

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medlinkNaloxone/medlink, a life-saving medication, is commonly administered by first responders to individuals who have overdosed on opioids and still have a pulse.

medlinkCardiac/medlink, antimalarial, and gastrointestinal therapies have fueled a 6% growth in India's pharmaceutical market in August. h2Indian

One of the reputed hospital groups of the CK Birla Hospitals, the BM Birla Heart Hospital has recently released a first of its kind report on the medlinkheart

Analysis of shared genomic segments, which indicate distant "relatedness," has uncovered undiagnosed cases of biLong QT syndrome, a rare condition

New lease of life was given to a woman who suffered four massive heart failures in one week due to severe Tuberculosis. The patient was admitted

medlinkMedicaid/medlink expansion provision of the Affordable Care Act to more people enhanced patient outcomes, prevention measures and screening access (!--ref1--).

September 29 is observed as World Heart Day

Tamil Nadu Chief Minister M.K. Stalin expressed shock over the death of former legislator and DMK spokesperson Kovai Selvaraj and extended his condolences.

Raipur, May 09: Former Chhattisgarh chief minister Ajit Jogi, 74, was admitted to a private hospital on Saturday after he suffered a cardiac arrest at his home this afternoon. Ajit Jogi''s health suddenly worsened while he was having breakfast, following

Cardiac arrest strikes almost 600,000 people each year, killing the vast majority of those individuals, says a new report from the Institute of Medicine. Every year in the U.S., approximately 395,000 cases of cardiac arrest occur outside of a hospital setting, in which less than 6 percent survive.

People exposed to fine particle (PM2.5) and ozone pollution are at increased risk of suffering out-of-hospital cardiac arrests, according to a recent Finnish study. Cardiac arrest is more likely within 24 hours after exposure to PM2.5 and up to several days after exposure to ozone.

Scientists hope to end heart transplant surgery forever thanks to help from the amazing zebrafish.

The patented technology for cardiac and fatigue risks monitoring was named the most promising for the insurance sector.

A chance encounter led to an ideal partnership

Peter C. Laussen, MD, discusses an article published in the May 2007 issue of Pediatric Critical Care Medicine, titled "Pediatric Staff Perspectives on Organ Donation After Cardiac Death in Children." Dr. Laussen is director of the cardiac intensive care unit at Children's Hospital Boston. This is the first podcast in a two-part interview. Part two will feature an interview with lead author Martha A.Q. Curley, RN, PhD. (Ped. Crit. Care Med. 2007;8[3]:212).

Martha A.Q. Curley, RN, PhD, associate professor of nursing, anesthesia and critical care medicine at the University of Pennsylvania and nurse scientist at Children’s Hospital in Boston, discusses an article published in the May 2007 issue of Pediatric Critical Care Medicine, "Pediatric staff perspectives on organ donation after cardiac death in children." (Ped. Crit. Care Med. 2007;8[3]:212).