NationDrugs.to introduces a reliable solution for patients searching for affordable and high-quality generic cancer drugs.

High-grade glioma (HGG), a type of aggressive brain cancer, accounts for the leading cause of cancer-related mortality for children and adolescents. 

Title: Breast Cancer Drug Might Help Men on Prostate Cancer Therapy
Category: Health News
Created: 8/28/2012 10:05:00 AM
Last Editorial Review: 8/28/2012 12:00:00 AM

Title: Breast Cancer Drug May Harm the Heart More Than Thought
Category: Health News
Created: 8/30/2012 6:05:00 PM
Last Editorial Review: 8/31/2012 12:00:00 AM

Early detection of drug-drug interactions (DDIs) can facilitate timely drug development decisions, prevent unnecessary restrictions on patient enrollment, resulting in clinical study populations that are not representative of the indicated study population, and allow for appropriate dose adjustments to ensure safety in clinical trials. All of these factors contribute to a streamlined drug approval process and enhanced patient safety. Here we describe a new approach for early prediction of the magnitude of change in exposure for cytochrome P450 (P450) CYP3A4-related DDIs of small-molecule anticancer drugs based on the model-based extrapolation of human-CYP3A4-transgenic mice pharmacokinetics to humans. Victim drugs brigatinib and lorlatinib were evaluated with the new approach in combination with the perpetrator drugs itraconazole and rifampicin. Predictions of the magnitude of change in exposure deviated at most 0.99- to 1.31-fold from clinical trial results for inhibition with itraconazole, whereas exposure predictions for the induction with rifampicin were less accurate, with deviations of 0.22- to 0.48-fold. Results for the early prediction of DDIs and their clinical impact appear promising for CYP3A4 inhibition, but validation with more victim and perpetrator drugs is essential to evaluate the performance of the new method.

BDR Pharmaceuticals has launched novel prostate cancer drug named "Enzalutamide" in 160 mg strength. Under the brand name BDENZA 160mg, it has introduced

Men taking either abiraterone or enzalutamide for advanced prostate cancer who had also undergone hormone therapy were at increased risk of serious metabolic

Using cancer drugs in malaria treatment can speed up the discovery process of new life-saving therapies for malaria, which is becoming increasingly drug-resistant.

Advaxis has announced that the U.S. Food and Drug Administration (FDA) has lifted the clinical hold on IND applications of its three drugs. Advaxis is

The US food and Drug Administration has announced that it has approved Amgen's supplemental new drug application for Kyprolis in combination with dexamethasone

The GST Council, led by Finance Minister Nirmala Sitharaman, has formed a Group of Ministers to evaluate reducing GST rates on life and health insurance,

Govt. had earlier scrapped customs duty on Trastuzumab, Osimertinib and Durvalumab and also reduced GST rates on them

Study shows how stopping one enzyme could help drugs treat an important class of cancers more effectively

This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemotherapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomicin C, imatinib, iressa and velcade (vortezomib). The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics.

RETIRED engineer Brian Cramp is a medical pioneer.

A team of Princeton chemists has identified a way to tag a protein's nearest molecular neighbors, enabling the precise mapping of their micro-environment. This could open new avenues to cancer treatment and other drug therapies.

Around half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, in a new study. Huseyin Naci,assistant professor of health policy a the London School of Economics joins us to talk about why potential bias may mean potential exaggeration of treatment effects, and could be...

Title: Cancer Drug Seems to Work by Activating Virus
Category: Health News
Created: 4/23/2010 2:10:00 PM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: FDA Approves Prostate Cancer Drug Zytiga
Category: Health News
Created: 4/29/2011 11:01:00 AM
Last Editorial Review: 4/29/2011 12:00:00 AM

Ayala Pharmaceuticals has two clinical-stage cancer drugs licensed from Bristol Myers Squibb. Now it has $55 million to take those drugs further than the pharmaceutical giant did. On Thursday evening, Ayala priced its IPO, which consisted of 3.7 million shares sold for $15 each. That price was the midpoint of the targeted $14 to $16 […]

Eil Lilly received accelerated FDA approval Friday for a drug that treats advanced cancers carrying a certain genetic signature. It’s the latest targeted cancer therapy to pass the regulatory bar and the first that addresses tumors characterized by aberrations in one particular gene. The gene in question, RET, produces a protein involved in cell signaling. […]

A US federal judge has ruled that generic versions of the cancer treatment Bendeka infringe on four separate patents, and has delayed them from launching until 2031.

Hazim Gaber, 22, of Edmonton, Canada, pleaded guilty today in Phoenix before U.S. Magistrate Judge Edward C. Voss to selling counterfeit cancer drugs using the Internet.

Hazim Gaber, 22, of Edmonton, Canada, was sentenced today in Phoenix by U.S. District Court Judge James A. Teilborg to 33 months in prison for selling counterfeit cancer drugs using the Internet.

Structural and biochemical differences among anticancer medications PARP inhibitors were linked to differing capacities to kill cancer cells, according

Chemotherapeutic drugs or antineoplastic agents used to treat various cancers enter the aquatic environment through human excretion and wastewater treatment facilities.

A new technology developed by scientists was found to help reveal the inner workings of individual cancer cells - potentially identifying more effective treatment combinations for people with cancer.

Two hormone treatments used in prostate cancer patients will be available before chemotherapy, as hospitals try to keep patients away from hospitals during the coronavirus crisis.

Leronlimab is a drug in development for treating HIV and cancer. Two of seven critically ill coronavirus patients who were given the drug were taken off ventilators in a matter of days.

Tokyo : Springer, 2019.

"Our aim is to make a preferred choice of therapy like Obynx available and more accessible to people suffering from cancer. Bridging these unmet gaps comes from our patient-first approach," Zydus Cadila MD Sharvil Patel told .

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These are the most important oncology stories you need to know about today.
Medscape Medical News

Biotech veteran Rosana Kapeller co-founded the start-up, which raised $50 million to develop small-molecule drugs