Alfa Cytology has introduced its advanced drug development services for brain tumors.

From guest blogger Kimberly Shannon Rhode Island Education Commissioner Deborah Gist has been diagnosed with a brain tumor and will undergo surgery in September, according to the Associated Press. She is expected to have a full recovery, but will be working a limited schedule until her operation. Af

Title: Gene Might Predict Brain Tumors' Aggressiveness
Category: Health News
Created: 8/27/2012 10:05:00 AM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: Multiple Brain Tumors Even More Malignant: Study
Category: Health News
Created: 8/24/2012 2:05:00 PM
Last Editorial Review: 8/27/2012 12:00:00 AM

Title: Senator John McCain Dies From Brain Tumor
Category: Health News
Created: 8/26/2018 12:00:00 AM
Last Editorial Review: 8/27/2018 12:00:00 AM

BACKGROUND AND PURPOSE:

Patients with brain tumors have high intersubject variation in putative language regions, which may limit the utility of straightforward application of healthy subject brain atlases in clinical scenarios. The purpose of this study was to develop a probabilistic functional brain atlas that consolidates language functional activations of sentence completion and Silent Word Generation language paradigms using a large sample of patients with brain tumors.

Researchers have identified an medlinkantidepressant/medlink called vortioxetine as a potential treatment for glioblastomas, at least in laboratory settings.

From guest blogger Kimberly Shannon Rhode Island Education Commissioner Deborah Gist has been diagnosed with a brain tumor and will undergo surgery in September, according to the Associated Press. She is expected to have a full recovery, but will be working a limited schedule until her operation. Af

T-cell immunoglobulin and mucin domain–containing molecule 3 (TIM-3), a potential immunotherapeutic target for cancer, has been shown to display diverse characteristics in a context-dependent manner. Thus, it would be useful to delineate the precise functional features of TIM-3 in a given situation. Here, we report that glial TIM-3 shows distinctive properties in the brain tumor microenvironment. TIM-3 was expressed on both growing tumor cells and their surrounding cells including glia and T cells in an orthotopic mouse glioma model. The expression pattern of TIM-3 was distinct from those of other immune checkpoint molecules in tumor-exposed and tumor-infiltrating glia. Comparison of cells from tumor-bearing and contralateral hemispheres of a glioma model showed that TIM-3 expression was lower in tumor-infiltrating CD11b+CD45mid glial cells but higher in tumor-infiltrating CD8+ T cells. In TIM-3 mutant mice with intracellular signaling defects and Cre-inducible TIM-3 mice, TIM-3 affected the expression of several immune-associated molecules including iNOS and PD-L1 in primary glia-exposed conditioned media (CM) from brain tumors. Further, TIM-3 was cross-regulated by TLR2, but not by TLR4, in brain tumor CM- or Pam3CSK4-exposed glia. In addition, following exposure to tumor CM, IFNγ production was lower in T cells cocultured with TIM-3–defective glia than with normal glia. Collectively, these findings suggest that glial TIM-3 actively and distinctively responds to brain tumor, and plays specific intracellular and intercellular immunoregulatory roles that might be different from TIM-3 on T cells in the brain tumor microenvironment.Significance:TIM-3 is typically thought of as a T-cell checkpoint receptor. This study demonstrates a role for TIM-3 in mediating myeloid cell responses in glioblastoma.

BACKGROUND AND PURPOSE:

Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma.

Babies with brain tumors are more likely to get benefitted from targeted treatment, finds a new study. Brain cancer in infants is biologically distinct

In children with brain tumors, hereditary genetic defect was found to destabilize protein regulation, revealed scientists from the Hopp Children's Cancer

People with the genetic condition neurofibromatosis type 1 (NF1) are more prone to developing tumors on nervous system tissue. A new study has found that

Combination of radiation and the schizophrenia drug trifluoperazine can help treat glioblastoma, one of the deadliest and most difficult-to-treat brain tumors.

A 57-year-old man from Sudan, who underwent a tumor removal surgery 15 years back, did not have any problems until 2018. He came to Aakash Healthcare

The talented percussionist died age 43 in the company of his wife Yaritza Blackwell, who announced the sad news

Taylor Swift has revealed that her mother Andrea Swift, 62, has been diagnosed with a brain tumor as she battles breast cancer.