Sruli Recht, the Reyjavik-based industrial designer with a penchant for the unusual, may have topped himself. His ATOR scarf, made of spider silk, was created with the help of both a spider and a goat:

"Our knit originates from the silk gland DNA of a spider, carefully placed in the milk ducts of a goat. A single filament is reeled out of the goat millimetres at a time to produce the most unobtainable fibre in the world."

"It takes several weeks to hand-loom the filament into this fabric quality, a further week gently coaxing the textile into the knotted web of this ghostly veil. [The scarf is] is woven, its proteins color treated with hot acid, then cured. After cutting it is twisted into a Möbius strip, and a flat felled seam is backstitched by hand with lengths of the same yarn, a holistic approach just short of felting, closing the loop."

"The edges are folded and pressed with agonizing slowness, before being bound with a Japanese thermally activated tape, a frosted, almost invisible finish."

"ATOR is made from one of the rarest multi-hyphenated materials in the world – genetically engineered spider-goat silk filament, hand-loomed, hand-dyed, hand-stitched, and hand-bound."

Considering that Recht could only get enough material to produce three of these, the €2,200 (USD $2,337) price doesn't seem that high.

Astrophysicists have produced a new model that focuses on the conditions created by the acceleration of the Universe’s expansion and the amount of stars formed.

The post New Theoretical Model Calculates Chances of Intelligent Life in Our Universe and Beyond appeared first on Sci.News: Breaking Science News.

Of pharmaceutical products, health care products packaging theory , there are several aspects of the law we need to , inter alia: 1 , generate new theory of pharmaceutical products , not only to consider the psychological factors of...

While the individual statements of belief that are included in the Apostles' Creed - even those not found in the Old Roman Symbol - are found in various writings by Irenaeus, Tertullian, Novatian, Marcellus, Rufinus, **Ambrose (about 337 A.D. - 397 A.D.), Augustine, Nicetus, and Eusebius Gallus, the earliest appearance of what we know as the Apostles' Creed was in the De singulis libris canonicis scarapsus ("Excerpt from Individual Canonical Books") of St. Priminius (Migne, Patrologia Latina 89, 1029 ff.), written between 710 A.D. and 714 A.D. This longer Creed seems to have arisen in what is now France and Spain. Charlemagne imposed it throughout his dominions, and it was finally accepted in Rome, where the Old Roman Creed or similar formulas had survived for centuries. -- {Note: The Christian Church historically has sought in large to be directed by the Gospels and the Apostolic Epistles of the New Testament - The Apostles' Creed is a classic and still currently relevant example of how true to form the Doctrines of the Church have remained in being faithful to the "common salvation" (Jude 1:3) as it was initially delivered to the Christian Church.}

Internship courses, unlike others, are multi-pronged because they require coordination at different levels. Typically, a faculty member coordinates the communication and implementation at each level to achieve the desired outcomes. We call the position that this faculty holds the “internship coordinator”. For the work of the internship coordinator to be successful, he/she may need to synchronize the work of the internship with all parties involved. Failure to coordinate at one level or another may affect the work of other parties involved in completing the internship for the students. This paper explains the experience of an internship program at the computer science department (COSC) at Indiana University Indiana University of Pennsylvania (IUP). We focus on the work of the internship coordinator for this program and his work to communicate and coordinate to successfully implement the internship experience for the students. We first discuss the theoretical foundation that led to the development of internship programs in academia and then elaborate on the multiple levels of the role of the internship coordinator in completing the internship experience for the students.

Aim/Purpose: The purpose of this study is to identify how Advanced level Mathematics and Mathematics course units offered at university level do impact on the academic performance of theoretical Computer Science course units. Background: In Sri Lankan state universities, students have been enrolled only from the Physical Science stream to do a degree program in Computer Science. In addition to that, universities have been offering some course units in Mathematics to provide the required mathematical maturity to Computer Science undergraduates. Despite of this it is observed that the failure rates in fundamental theoretical Computer Science course units are much higher than other course units offered in the general degree program every year. Methodology : Academic records comprised of all 459 undergraduates from three consecutive batches admitted to the degree program in Computer Science from a university were considered for this study. Contribution: This study helps academics in identifying suitable curricula for Mathematics course units to improve students’ performance in theoretical Computer Science courses. Findings: Advanced level Mathematics does not have any significant effect on the academic performance of theoretical Computer Science course units. Even though all Mathematics course units offered were significantly correlated with academic performance of every theoretical Computer Science course unit, only the Discrete Mathematics course unit highly impacted on the academic performance of all three theoretical Computer Science course units. Further this study indicates that the academic performance of female undergraduates is better than males in all theoretical Computer Science and Mathematics course units. Future Research: Identifying other critical success factors contributing to the students’ academic performance of the theoretical Computer Science through empirical studies

Aim/Purpose: Absence of new scientific approaches and specialists (generalists), who professionally obtain such approaches, is one of the main reasons for an ineffective solution of complex multifactor problems of the modern society. Background: The article briefly describes the concept of systems transdisciplinary integration of knowledge of different scientific disciplines. Also, it shows an opportunity to use this concept education of generalists in higher education. Methodology: The article highlights the idea of gestalt of knowledge, which is based on systems transdisciplinary model of spatial unit of order. It describes the basis of gestalt-of-the-one and gestalt-of-the-whole. Also, it explains the differences and practical capabilities of holist generalists and unicentrist generalists. Contribution: Loss of identificational attributes can take place during the process of integration of knowledge of different scientific disciplines. The article shows how to avoid this complication within a systems transdisciplinary approach. Findings: Each type of fundamental knowledge has its own carriers, such as scientists and specialists. Therefore, direct interaction of people-carriers of fundamental knowledge has limited potential. Presently, a more practical importance is the interaction between scientists and specialists within the zones of hybridization of fundamental knowledge. Hybridization is the process of systematization of knowledge within specialized systems transdisciplinary models of unit of order. A specialist generalist’s professional work is to organize scientific research, systemise knowledge of different scientific disciplines, make necessary conclusions, and suggest optimal solution for complex multifactor problems. Therefore, generalists should be considered as an important move towards the solution of complex multifactor problems of modern society. Recommendation for Researchers: A new scientific approach is a way of widening scientific worldview. A new approach in inorganic chemistry made it possible to create the Mendeleev periodic table of elements. Owing to this table, researchers were able to learn the characteristics and attributes of chemical elements, which can be found in nature. Also, models of systems transdisciplinary approach allow the discovery of new elements and relations of complex multifactor problems. Its absence would, however, hinder the research and the problem description. Future Research: The article justifies that preparation of generalists in higher education is one of the main peculiarities of universities of the third generation. Therefore, it might be desirable for organizers of higher education and university leaders to begin speculations regarding this quest, develop educational programs for generalists, and search for optimal forms and methods of solution.

CEO severance has captured the attention of a wide array of audiences, yet it remains largely unexplored by management scholars. This paper offers a rigorous theoretical examination of CEO severance with the goal of developing a foundation for a systematic research agenda. In particular, we consider if, and how, severance agreements can be effective in serving the interests of both CEOs and shareholders. We argue that severance agreements have potential value as both an executive recruitment and governance tool, but that the way they are conventionally structured undermines the value that shareholders realize from them. The implications of structure have been almost entirely overlooked by scholars, perhaps because the influence of compensation consultants has left little variance in how severance agreements are implemented across firms. We address this gap by theorizing about how severance agreements could be structured to effectively generate value for executives and shareholders. To do this, we introduce a categorization of key dimensions of CEO severance agreements, and consider how each of these dimensions can be structured to facilitate CEO recruiting, while simultaneously mitigating future governance problems. Our propositions offer new opportunities for governance and compensation scholars to link CEO severance agreements to important organizational outcomes.

GMO is a common term used by consumers to describe foods that have been created through genetic engineering. While GMOs have been available to consumers since the early 1990s and are a common part of today's food supply, research shows consumers have limited knowledge and understanding about what GMOs are, why they are used, and how they are made.

Children's Geographies; 02/01/2022
(AN 154441555); ISSN: 14733285
Academic Search Premier

Mycobacterium tuberculosis can reside and persist in deep tissues; latent tuberculosis can evade immune detection and has a unique mechanism to convert it into active disease through reactivation. M. tuberculosis Rv1421 (MtRv1421) is a hypothetical protein that has been proposed to be involved in nucleotide binding-related metabolism in cell-growth and cell-division processes. However, due to a lack of structural information, the detailed function of MtRv1421 remains unclear. In this study, a truncated N-terminal domain (NTD) of MtRv1421, which contains a Walker A/B-like motif, was purified and crystallized using PEG 400 as a precipitant. The crystal of MtRv1421-NTD diffracted to a resolution of 1.7 Å and was considered to belong to either the C-centered monoclinic space group C2 or the I-centered orthorhombic space group I222, with unit-cell parameters a = 124.01, b = 58.55, c = 84.87 Å, β = 133.12° or a = 58.53, b = 84.86, c = 90.52 Å, respectively. The asymmetric units of the C2 or I222 crystals contained two or one monomers, respectively. In terms of the binding ability of MtRv1421-NTD to various ligands, uridine diphosphate (UDP) and UDP-N-acetylglucosamine significantly increased the melting temperature of MtRv1421-NTD, which indicates structural stabilization through the binding of these ligands. Altogether, the results reveal that a UDP moiety may be required for the interaction of MtRv1421-NTD as a nucleotide-binding protein with its ligand.

Accurate analysis of the rich information contained within X-ray spectra usually calls for detailed electronic structure theory simulations. However, density functional theory (DFT), time-dependent DFT and many-body perturbation theory calculations increasingly require the use of advanced codes running on high-performance computing (HPC) facilities. Consequently, many researchers who would like to augment their experimental work with such simulations are hampered by the compounding of nontrivial knowledge requirements, specialist training and significant time investment. To this end, we present Web-CONEXS, an intuitive graphical web application for democratizing electronic structure theory simulations. Web-CONEXS generates and submits simulation workflows for theoretical X-ray absorption and X-ray emission spectroscopy to a remote computing cluster. In the present form, Web-CONEXS interfaces with three software packages: ORCA, FDMNES and Quantum ESPRESSO, and an extensive materials database courtesy of the Materials Project API. These software packages have been selected to model diverse materials and properties. Web-CONEXS has been conceived with the novice user in mind; job submission is limited to a subset of simulation parameters. This ensures that much of the simulation complexity is lifted and preliminary theoretical results are generated faster. Web-CONEXS can be leveraged to support beam time proposals and serve as a platform for preliminary analysis of experimental data.

The complex [Pt(C9H6NO)Cl(C2H4)], (I), was synthesized and structurally characterized by ESI mass spectrometry, IR, NMR spectroscopy, DFT calculations and X-ray diffraction. The results showed that the deprotonated 8-hy­droxy­quinoline (C9H6NO) coordinates with the PtII atom via the N and O atoms while the ethyl­ene coordinates in the η2 manner and in the trans position compared to the coordinating N atom. The crystal packing is characterized by C—H⋯O, C—H⋯π, Cl⋯π and Pt⋯π inter­actions. Complex (I) showed high selective activity against Lu-1 and Hep-G2 cell lines with IC50 values of 0.8 and 0.4 µM, respectively, 54 and 33-fold more active than cisplatin. In particular, complex (I) is about 10 times less toxic to normal cells (HEK-293) than cancer cells Lu-1 and Hep-G2. Furthermore, the reaction of complex (I) with guanine at the N7 position was proposed and investigated using the DFT method. The results indicated that replacement of the ethyl­ene ligand with guanine is thermodynamically more favorable than the Cl ligand and that the reaction occurs via two consecutive steps, namely the replacement of ethyl­ene with H2O and the water with the guanine mol­ecule.

Many U.S. farmers who grow genetically engineered (GE) crops are realizing substantial economic and environmental benefits -- such as lower production costs, fewer pest problems, reduced use of pesticides, and better yields -- compared with conventional crops, says a new report from the National Research Council.

An extensive study by the National Academies of Sciences, Engineering, and Medicine has found that new technologies in genetic engineering and conventional breeding are blurring the once clear distinctions between these two crop-improvement approaches.

The National Academies Committee on Genetically Engineered Crops - Past Experiences and Future Prospects authored an almost 600-page landmark report, released in May 2016. It was perhaps the most comprehensive analysis of genetically engineered crops to date.

The AesthetiCare Consultation improves patient care and treatment through complimentary one-hour session with a true skincare professional.

Meticap, a reusable medication timing cap retail add-on product that ensures patients take medication on time, announces custom co-branding options for pharmacies, clinics, and veterinary hospitals.

ALFRED PETS, INC, a company that envisions harmony between pets and the environment, is launching its eco-friendly cat litter ETICAT+, made from recycled coffee grounds, through the global crowdfunding platform Kickstarter.

In a series of hypothetical case studies, this program will reveal the inner workings of the claims handling and litigation process through a didactic dialogue from an attorney's intake of…

Co.Design asked Tobias Frere-Jones of Hoefler & Co. to give his thoughts on Apple’s choice of Helvetica as an interface typeface for the upcoming OS X Yosemite update:

Despite its grand reputation, Helvetica can’t do everything. It works well in big sizes, but it can be really weak in small sizes. Shapes like ‘C’ and ‘S’ curl back into themselves, leaving tight “apertures”–the channels of white between a letter’s interior and exterior. So each shape halts the eye again and again, rather than ushering it along the line. The lowercase ‘e,’ the most common letter in English and many other languages, takes an especially unobliging form. These and other letters can be a pixel away from being some other letter, and we’re left to deal with flickers of doubt as we read.

This reminds me of what Erik Spiekerman wrote about Helvetica:

[Helvetica] really wasn’t designed for small sizes on screens. Words like milliliter can be very difficult to decipher. If you ever had to read or write a password with 1, i, l or I, you know the problem.

Still, I wouldn’t keep Lucida Grande for HiDPI displays. With a 2× resolution jump (4× pixels) pixel fitting becomes less of an issue, and pixel optimized typefaces like Lucida Grande begin to look crude in comparison with typefaces made primarily for print. Legibility obviously still matters just as much, but the choice need no longer be bound to fonts optimized for low resolution displays.

Sometimes, the only way to make an impact is to be loud. This hour, three female performers talk about the rewards — and consequences — that come from speaking out and making people feel uncomfortable. Guests include comedian Lilly Singh, Pussy Riot co-founder Nadya Tolokonnikova and actor, playwright and director Sarah Jones.

Original Broadcast Date: October 20, 2023.

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Genetically Rescued Organism: Toward A Solution For Sudden Oak Death

The world's richest man once said Donald Trump's character didn't 'reflect well' on the U.S. Now Elon Musk is touring the country, and spending big, to put Trump and other Republicans in power.

Scientists modified Toxoplasma gondii to deliver a potential Rett Syndrome therapeutic to the mouse brain. 

Rene Ritchie returns to the show for a recap of this week’s “California Streaming” Apple Event: the iPhones 13, Apple Watch Series 7, and new iPads. Also, last week’s decision in the Apple v. Epic lawsuit.

Censorship is antithetical to the scientific method because it requires free speech and open debate and skepticism Continue reading →

Human beings and chimps share as much as 98 percent of their DNA. If our species are so similar, can chimps be genetically engineered to be more like us?

to write exegetical paper

High-throughput sequencing (HTS) technologies have been instrumental in investigating biological questions at the bulk and single-cell levels. Comparative analysis of two HTS data sets often relies on testing the statistical significance for the difference of two negative binomial distributions (DOTNB). Although negative binomial distributions are well studied, the theoretical results for DOTNB remain largely unexplored. Here, we derive basic analytical results for DOTNB and examine its asymptotic properties. As a state-of-the-art application of DOTNB, we introduce DEGage, a computational method for detecting differentially expressed genes (DEGs) in scRNA-seq data. DEGage calculates the mean of the sample-wise differences of gene expression levels as the test statistic and determines significant differential expression by computing the P-value with DOTNB. Extensive validation using simulated and real scRNA-seq data sets demonstrates that DEGage outperforms five popular DEG analysis tools: DEGseq2, DEsingle, edgeR, Monocle3, and scDD. DEGage is robust against high dropout levels and exhibits superior sensitivity when applied to balanced and imbalanced data sets, even with small sample sizes. We utilize DEGage to analyze prostate cancer scRNA-seq data sets and identify marker genes for 17 cell types. Furthermore, we apply DEGage to scRNA-seq data sets of mouse neurons with and without fear memory and reveal eight potential memory-related genes overlooked in previous analyses. The theoretical results and supporting software for DOTNB can be widely applied to comparative analyses of dispersed count data in HTS and broad research questions.

bAedes aegypti mosquitoes/b, a small percentage of all the mosquitoes species in the Florida Keys causes diseases including dengue and Zika. iScience

Using next-generation sequencing (NGS) technology, researchers were able to pinpoint specific areas of a person's DNA to more effectively diagnose genetic

Elevator rides are often perceived as mundane and uneventful. However, customization has the power to transform these moments into memorable experiences.