SARS continues to deny amaBhungane and the Financial Mail's requests for access to former president Jacob Zuma's tax records despite the seminal judgment of the Constitutional Court handed down in May 2023.

Another budget and a bigger debt mountain to climb than ever before. Can Finance Minister Enoch Godongwana change the trajectory? writes Carol Paton.

Despite criticism of electioneering, the Government Communication and Information System (GCIS) has defended its R7 million social-reality television show.

SAA now remains firmly in state hands - a state that it insists it can no longer provide the type of capital support it desperately needs. Who should feel vindicated? asks Khaya Sithole.

Most time management strategies are dropped as quickly as they are picked up for one key reason: insight is so much more important than theory, says Ian Mann. And this author's insight is invaluable.

Scholars have identified several reasons why cities want to host the Games, and there's little evidence to support some of the claims. But that doesn't mean it's not worth doing, says Johan Fourie.

In the latest Auditor-General report, what stands out is persistent underperformance and the level of desperation in local governments. Reliance on consultants who don't solve the underlying problem is no longer sustainable, says Khaya Sithole.

Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

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