automobile Škoda Auto extends car warranties until 31 August across global markets except China By www.financialexpress.com Published On :: 2020-05-09T17:36:00+05:30 The Skoda warranty extension applies worldwide to all Skoda vehicles, with the exception of vehicles produced in China or for the Chinese market. Full Article
automobile Over 600 road accidents, 140 fatalities recorded in India during lockdown: SaveLife Foundation study By www.financialexpress.com Published On :: 2020-05-09T17:54:00+05:30 140 people died while 600 accidents were recorded on Indian roads amid the nationwide lockdown. Many of them were migrant labourers returning home Full Article
automobile Elantra vs. Corolla, 2020 BMW 8-Series Gran Coupe review, VW's EV plans: What's New @ The Car Connection By www.thecarconnection.com Published On :: Tue, 05 May 2020 11:30:00 -0400 2020 Hyundai Elantra vs. 2020 Toyota Corolla: Compare Cars The 2020 Toyota Corolla and 2020 Hyundai Elantra are two compact cars—and hatchbacks—that are great values with thrifty hybrids. Mailbag: What's the difference between car, crossover, and SUV anyway? "Why isn't an SUV a station wagon or a crossover?" a perplexed reader wrote... Full Article Today in Car News
automobile 2020 Hyundai Elantra vs. 2020 Toyota Corolla: Compare Cars By www.thecarconnection.com Published On :: Tue, 05 May 2020 11:31:00 -0400 Compact sedans like the Elantra and Corolla mostly form the role of commuter cars in American households, and they’re spacious enough to be family vehicles for those with smaller kids or pets to put in the back seat. If your budget is tight, the 2020 Toyota Corolla and 2020 Hyundai Elantra are two of the best values on the market. They both... Full Article
automobile Pickup trucks outsell cars for the first time, and it may not be temporary By www.thecarconnection.com Published On :: Tue, 05 May 2020 15:56:00 -0400 The Ford F-150, Ram 1500, and Chevy Silverado have been the best-selling light vehicles in America for a long time, but for the first time ever, the pickup truck segment as a whole outsold the car segment in the month of April, Bloomberg reported on Tuesday. The difference was by a large margin, too, with pickups outselling cars by more than... Full Article
automobile 2021 Kia Sedona By www.thecarconnection.com Published On :: Wed, 06 May 2020 09:44:00 -0400 The 2021 Kia Sedona minivan sits across the lot from more interesting family crossovers and vehicles. (That it shares the same showroom as the Telluride crossover is just not fair, man.) Still, some families can’t escape the need for comfortable transportation for two or more small children. And for convenience, it’s hard to top a van... Full Article
automobile Explorer vs Pilot, 2020 Genesis G70 review, Camry vs Sonata Hybrids: What's New @ The Car Connection By www.thecarconnection.com Published On :: Wed, 06 May 2020 11:45:00 -0400 2020 Honda Pilot vs. 2020 Ford Explorer: Compare Crossover SUVs Two of the bestselling three-row SUVs, the 2020 Honda Pilot and 2020 Ford Explorer, go about their family business a bit differently. Pickup trucks outsell cars for the first time, and it may not be temporary The Ford F-150, Ram 1500, and Chevy Silverado have been the best-selling... Full Article Today in Car News
automobile 2020 Honda Pilot vs. 2020 Ford Explorer: Compare Crossover SUVs By www.thecarconnection.com Published On :: Wed, 06 May 2020 11:55:00 -0400 Three-row crossover SUVs are having their day in the sun. These family haulers provide the spaciousness and safety of a minivan with the style and performance of something less...egg-shaped. Two of the bestselling three-row SUVs, the 2020 Honda Pilot and 2020 Ford Explorer, go about their family business a bit differently. What the Pilot lacks in... Full Article
automobile Report: Traffic fatalities decreased, miles driven increased in 2019 By www.thecarconnection.com Published On :: Thu, 07 May 2020 07:00:00 -0400 Estimated traffic fatalities decreased in 2019 despite an increase in driving, according to a report from the NHTSA released on Wednesday. There were projected to be 36,120 traffic fatalities in 2019, which is a 1.2% decrease from 2018. It marks the third consecutive year of declines from a post-recession high point of 37,806 traffic fatalities in... Full Article
automobile Review update: The 2020 Mercedes-Benz AMG GLC 43 SUV "nose" the right spice level By www.thecarconnection.com Published On :: Thu, 07 May 2020 10:30:00 -0400 These are halcyon days for fleet-footed crossover SUVs. Saucy ‘utes like the 2020 Mercedes-Benz GLC 43 AMG hardly look like they’re just as quick as their smaller siblings but stopwatches don’t lie. In the example above, Mercedes says the GLC43 crossover takes just 4.7 seconds from 0-60 mph compared to the C43 sedan’s time... Full Article
automobile 5 things to know about Uconnect 5 By www.thecarconnection.com Published On :: Thu, 07 May 2020 11:30:00 -0400 Fiat Chrysler Automobiles’ Uconnect 5 is the latest update to one of the few native infotainment systems that is preferable to smartphone connections. Improvements to the system include five times faster processing power, larger touchscreens with three times better resolution, over-the-air updates for seamless patches to the system, and an... Full Article Infotainment
automobile 2020 Mercedes GLC 43 review, Lambo Huracan gets RWD option, XC90 EV goes semi-autonomous: What's New @ The Car Connection By www.thecarconnection.com Published On :: Thu, 07 May 2020 11:38:00 -0400 Review update: The 2020 Mercedes-Benz AMG GLC 43 SUV "nose" the right spice level These are halcyon days for fleet-footed crossover SUVs. Saucy ‘utes like the 2020 Mercedes-Benz GLC 43 AMG hardly look like they’re just as quick as their smaller siblings but stopwatches don’t lie. 5 things to know about Uconnect 5 Uconnect 5, the... Full Article Today in Car News
automobile IIHS reports that new Jeep Wrangler SUV rolled over on its side during driver-side crash By www.thecarconnection.com Published On :: Thu, 07 May 2020 11:45:00 -0400 The IIHS reported Thursday that the new Jeep Wrangler, which was last comprehensively updated for the 2018 model year, tipped over onto its passenger side during its driver-side small overlap crash test. The insurance industry-funded safety watchdog said the Wrangler was tested three times, twice by the agency and once by the automaker. The... Full Article
automobile Jerry Seinfeld's "Comedians In Cars Getting Coffee" is out of gas By www.motorauthority.com Published On :: Fri, 08 May 2020 09:45:00 -0400 After 11 seasons and more than 80 episodes, it looks like funny man and avid car nut Jerry Seinfeld's "Comedians In Cars Getting Coffee" is finally running out of gas. During a press conference to discuss his new Netflix special “Jerry Seinfeld: 23 Hours to Kill,” Seinfeld said he feels like there's nothing left to achieve with... Full Article Jerry Seinfeld Comedians In Cars Getting Coffee
automobile 2020 Mercedes-Benz A-Class vs 2020 Mercedes-Benz CLA-Class: Compare Cars By www.thecarconnection.com Published On :: Fri, 08 May 2020 10:35:00 -0400 Many car buyers aspire to own a Mercedes-Benz. The cars are a symbol of quality, bulletproof German engineering, and, yes, status. But if you can’t get the lord to buy you a Mercedes-Benz, you have to do it yourself, and that can really stretch the budget. Mercedes answers that issue with its two lowest-priced cars, the A-Class and... Full Article
automobile BMW M5 CS, Porsche Cayenne GTS Coupe, Porsche Track Precision App: Car News Headlines By www.motorauthority.com Published On :: Fri, 08 May 2020 11:00:00 -0400 BMW has been spotted testing what appears to be a new performance flagship for the M5 range. Word on the street is that the car, which will likely be dubbed an M5 CS, is powered by a newly developed V-8. Porsche looks to be readying a Cayenne GTS Coupe to help bridge the performance gap between the S and Turbo. The new variant should debut next... Full Article Today in Car News
automobile Mobile fast-charging: A must-have for electric truck and bus fleets? By www.greencarreports.com Published On :: Fri, 08 May 2020 11:00:00 -0400 Fully electric delivery trucks, cargo vans, shuttle vehicles, and transit and school buses are all due to become increasingly common as fleets go green and diesels are retired. That’s where a recent surge of interest in mobile-charging solutions comes in. As a backup plan for the times when charge points and infrastructure won’t quite... Full Article charging
automobile 2021 Audi Q3 By www.thecarconnection.com Published On :: Fri, 08 May 2020 11:00:00 -0400 We’re keen on small crossovers like the 2021 Audi Q3, and by looking at the road outside our windows, everyone else is too. This year, the Q3 returns and it’s largely the same as last year, except the price. The 2021 Audi Q3 nets a 6.7 TCC Rating, propelled by good safety scores and standard features. (Read more about how we rate... Full Article
automobile A-Class vs. CLA-Class, Lego Porsche builds bonds, mobile fast-charging future: What's New @ The Car Connection By www.thecarconnection.com Published On :: Fri, 08 May 2020 11:30:00 -0400 2020 Mercedes-Benz A-Class vs 2020 Mercedes-Benz CLA-Class: Compare Cars If you can’t get the lord to buy you a Mercedes-Benz, you have to do it yourself, and that can really stretch the budget. Mercedes answers that issue with its two lowest-priced cars, the A-Class and CLA-Class. IIHS reports that new Jeep Wrangler SUV rolled over on its... Full Article Today in Car News
automobile New Tesla Roadster likely years away from production By www.motorauthority.com Published On :: Fri, 08 May 2020 11:45:00 -0400 At the reveal of Tesla's redesigned Roadster in 2017, the company said the car would start production in 2020. At the time we said the company was notorious for being late on deadlines, and we were right to say it. In a podcast interview with comedian Joe Rogan on Thursday, Tesla CEO Elon Musk said the redesigned Roadster would be pushed back to... Full Article
automobile Last-mile electric van, clean-energy pinch, mobile charging for trucks: Today’s Car News By www.greencarreports.com Published On :: Fri, 08 May 2020 11:50:00 -0400 Nissan’s Leaf-based van for Europe gets larger. More mobile charging is on the way for bigger electric trucks. And could the pandemic pinch material supply for EV makers and the clean energy sector? This and more, here at Green Car Reports. The coronavirus pandemic could tighten the supply of some materials needed for the creation of... Full Article Today in Car News
automobile W Motors lends help in Genius Garage's Porsche Boxster Lykan Hypersport conversion By www.motorauthority.com Published On :: Fri, 08 May 2020 13:00:00 -0400 A build team in Ohio is in the process of turning an old Porsche Boxster into a supercar that was limited to just seven units worldwide and originally priced at $3.4 million. The car we're talking about is the W Motors Lykan Hypersport that bowed in 2013, and a replica was recently acquired by a workshop in Bowling Green, Ohio. The replica was... Full Article Videos Replica youtube W Motors
automobile 2020 BMW 8-Series Gran Coupe, 2020 Genesis G70, 2020 Chevrolet Corvette: The Week In Reverse By www.motorauthority.com Published On :: Fri, 08 May 2020 14:00:00 -0400 We spent some time in the 2020 BMW 8-Series Gran Coupe; we drove the 2020 Genesis G70; and coronavirus has affected the 2020 Chevrolet Corvette. It's the Week in Reverse, right here at Motor Authority. The 2020 BMW 8-Series Gran Coupe is a more stylish four-door alternative to the 7-Series. We found it has a Teutonic rumble from its twin-turbo... Full Article The Week In Reverse
automobile Colin Chapman's Lotus Esprit is for sale By www.motorauthority.com Published On :: Fri, 08 May 2020 15:35:00 -0400 A Lotus Esprit formerly owned by company founder Colin Chapman is up for sale through British dealer Mark Donaldson. As detailed by Motor Sport, the car is a 1981 Series 3 Turbo model with some modifications specified by Chapman, including power steering and a pollen filter to help alleviate his hay fever. The car rides on a lowered suspension... Full Article Colin Chapman Lotus
automobile Why it's so hard to make supercars street legal By www.motorauthority.com Published On :: Sat, 09 May 2020 06:00:00 -0400 Supercars may push automotive design and engineering to the extreme, but they still need to follow the same regulations as ordinary sedans and crossovers. Making a supercar street legal is the hardest part of the development process, Christian von Koenigsegg said in a recent interview with Apex One. Here's why that is so hard. While regulations... Full Article Videos Koenigsegg
automobile 2020 Hyundai Sonata By www.thecarconnection.com Published On :: Sat, 09 May 2020 08:00:00 -0400 Although midsize sedans might no longer be the heart of the American market, Hyundai is showing with the redesigned 2020 Sonata that it can put its heart into one. The 2020 Hyundai Sonata has a dramatic new design language that finally brings the exterior look of this sedan up to the higher standard for its cabin that it introduced with the... Full Article
automobile Camry Hybrid vs. Sonata Hybrid, mobile charging, Cash for Clunkers redux: The Week in Reverse By www.greencarreports.com Published On :: Sat, 09 May 2020 08:00:00 -0400 Sales of which electric car plunged the steepest leading into the U.S. pandemic slowdown? Which automaker reaffirmed its commitment to hydrogen fuel cells? This is our look back at the Week In Reverse—right here at Green Car Reports—for the week ending May 8, 2020. Our biggest combination of stories this week related to the most... Full Article The Week In Reverse
automobile Porsche 718 Cayman GT4 RS, Brabham BT62, Genesis G70: This Week's Top Photos By www.motorauthority.com Published On :: Sat, 09 May 2020 08:00:00 -0400 The rumor mill has been going into overdrive with news that a Porsche 718 Cayman GT4 RS is coming. Giving some credence to the rumors is a prototype spied this week of a Cayman even more hardcore than the GT4. Another prototype we spied was what appeared to be a new performance flagship for the M5 range. Word on the street is that the car, which... Full Article Photos Of The Week
automobile Paul’s Doubts About the Galatians By feeds.gty.org Published On :: Fri, 08 May 2020 00:00:00 PST Galatians 4:19–20 Full Article Galatians 4:19–20
automobile HARMAN Experts Discuss the Future of Automotive Audio at the 2019 AES International Conference By news.harman.com Published On :: Wed, 04 Sep 2019 15:33:00 GMT The car is expected to change more in the next five years than it has in the last fifty. What will the future of automotive audio look like? What challenges will suppliers and OEMs alike face in the coming years? At the upcoming International Conference... Full Article
automobile The 1980s Futuristic Dream Car is now a Reality By news.harman.com Published On :: Wed, 02 Oct 2019 12:43:00 GMT What do KITT from Knight Rider, the Batmobile and Doc Brown's Delorean from Back to the Future all have in common? All three ignited our imaginations about what is truly possible within the automotive realm. But, when those cars first entered pop... Full Article
automobile HARMAN Technology Forum: Intelligent Technology is Here... Are We Ready? By news.harman.com Published On :: Wed, 16 Oct 2019 17:33:00 GMT In today’s age where data is king and smart technologies are abundant, customer experience is more important than ever before. But is the world ready to fully embrace the intelligent technologies that are being designed to boost consumer engagement and... Full Article
automobile National Cybersecurity Awareness Month 2019: Q&A with HARMAN’s Asaf Atzmon By news.harman.com Published On :: Fri, 25 Oct 2019 14:30:00 GMT With the 2019 National Cybersecurity Awareness Month (NCSAM) upon us, we decided to get the latest download on the state of cybersecurity in the automotive industry from HARMAN’s Vice President & General Manager of Automotive Cybersecurity, Asaf Atzmon.... Full Article
automobile Listen Today: HARMAN Launches New Experiences Per Mile Podcast By news.harman.com Published On :: Thu, 12 Dec 2019 05:00:00 GMT Consumers are constantly exploring new ways to connect to the world around them both in and outside of their vehicles. At HARMAN, enabling connected experiences is at the core of everything we do. That’s why we’re launching the Experiences Per Mile... Full Article
automobile Redefining What Moves You: How HARMAN is Powering the Digital Lifestyle By news.harman.com Published On :: Thu, 02 Jan 2020 15:16:00 GMT For over 70 years, HARMAN has been at the forefront of the some of the most groundbreaking megatrends in the audio and automotive technology industries – from the first home stereo receiver to in-car radios to today’s sophisticated digital cockpits. Now,... Full Article
automobile HARMAN Showcases Life-Saving Potential of Vehicle-to-Pedestrian 5G Technology at CES 2020 By news.harman.com Published On :: Mon, 06 Jan 2020 13:00:00 GMT CES 2020 – LAS VEGAS, Nev. – January 6, 2020 – HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies and solutions for automotive, consumer and enterprise markets, today unveiled a new ADAS use case, called... Full Article
automobile HARMAN Unveils the HARMAN ExP Integrated Solution Suite at CES 2020 – Elevating Automotive Tech into Meaningful Consumer Driving Experiences By news.harman.com Published On :: Mon, 06 Jan 2020 13:00:00 GMT CES 2020 - LAS VEGAS, NV - JANUARY 6, 2020 – HARMAN, a wholly-owned subsidiary of Samsung Electronics Co., Ltd., focused on connected technologies for automotive, consumer and enterprise markets, today launched the HARMAN ExP Integrated Solution Suite,... Full Article
automobile HARMAN Unwraps Transformative ExP Automotive Technologies at CES 2020 By news.harman.com Published On :: Tue, 21 Jan 2020 16:15:00 GMT Each year, the HARMAN team returns to the annual Consumer Electronics Show in Las Vegas to introduce best-in-class products and solutions that will transform key industries like automotive, audio and technology. Earlier this year at the Hard Rock Hotel &... Full Article
automobile We’re All Ears for No Shark Fins—Smart Conformal Antenna By news.harman.com Published On :: Wed, 22 Jan 2020 17:47:00 GMT Embedded connectivity is one of the latest technological trends that has been enthusiastically embraced by the automotive industry. As the modern car becomes increasingly connected, the number of vehicle radio services for aviation, infotainment, ADAS... Full Article
automobile Hyundai Motor Company and HARMAN International launch the world’s first road noise cancellation system into production By news.harman.com Published On :: Mon, 03 Feb 2020 15:00:00 GMT Stamford, Connecticut – February 03, 2020 – HARMAN International, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. focused on connected technologies for automotive, consumer and enterprise markets, has launched the world’s first active road... Full Article
automobile Issues and Events By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 Full Article
automobile Erratum. Ten-Year Outcome of Islet Alone or Islet After Kidney Transplantation in Type 1 Diabetes: A Prospective Parallel-Arm Cohort Study. Diabetes Care 2019;42:2042-2049 By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 Full Article
automobile Sex Disparities in Cardiovascular Outcome Trials of Populations With Diabetes: A Systematic Review and Meta-analysis By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 BACKGROUND Sex differences have been described in diabetes cardiovascular outcome trials (CVOTs). PURPOSE We systematically reviewed for baseline sex differences in cardiovascular (CV) risk factors and CV protection therapy in diabetes CVOTs. DATA SOURCES Randomized placebo-controlled trials examining the effect of diabetes medications on major adverse cardiovascular events in people ≥18 years of age with type 2 diabetes. STUDY SELECTION Included trials reported baseline sex-specific CV risks and use of CV protection therapy. DATA EXTRACTION Two reviewers independently abstracted study data. DATA SYNTHESIS We included five CVOTs with 46,606 participants. We summarized sex-specific data using mean differences (MDs) and relative risks (RRs) and pooled estimates using random effects meta-analysis. There were fewer women than men in included trials (28.5–35.8% women). Women more often had stroke (RR 1.28; 95% CI 1.09, 1.50), heart failure (RR 1.30; 95% CI 1.21,1.40), and chronic kidney disease (RR 1.33; 95% CI 1.17; 1.51). They less often used statins (RR 0.90; 95% CI 0.86, 0.93), aspirin (RR 0.82; 95% CI 0.71, 0.95), and β-blockers (RR 0.93; 95% CI 0.88, 0.97) and had a higher systolic blood pressure (MD 1.66 mmHg; 95% CI 0.90, 2.41), LDL cholesterol (MD 0.34 mmol/L; 95% CI 0.29, 0.39), and hemoglobin A1c (MD 0.11%; 95% CI 0.09, 0.14 [1.2 mmol/mol; 1.0, 1.5]) than men. LIMITATIONS We could not carry out subgroup analyses due to the small number of studies. Our study is not generalizable to low CV risk groups nor to patients in routine care. CONCLUSIONS There were baseline sex disparities in diabetes CVOTs. We suggest efforts to recruit women into trials and promote CV management across the sexes. Full Article
automobile Effects of Continuous Glucose Monitoring on Metrics of Glycemic Control in Diabetes: A Systematic Review With Meta-analysis of Randomized Controlled Trials By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 BACKGROUND Continuous glucose monitoring (CGM) provides important information to aid in achieving glycemic targets in people with diabetes. PURPOSE We performed a meta-analysis of randomized controlled trials (RCTs) comparing CGM with usual care for parameters of glycemic control in both type 1 and type 2 diabetes. DATA SOURCES Many electronic databases were searched for articles published from inception until 30 June 2019. STUDY SELECTION We selected RCTs that assessed both changes in HbA1c and time in target range (TIR), together with time below range (TBR), time above range (TAR), and glucose variability expressed as coefficient of variation (CV). DATA EXTRACTION Data were extracted from each trial by two investigators. DATA SYNTHESIS All results were analyzed by a random effects model to calculate the weighted mean difference (WMD) with the 95% CI. We identified 15 RCTs, lasting 12–36 weeks and involving 2,461 patients. Compared with the usual care (overall data), CGM was associated with modest reduction in HbA1c (WMD –0.17%, 95% CI –0.29 to –0.06, I2 = 96.2%), increase in TIR (WMD 70.74 min, 95% CI 46.73–94.76, I2 = 66.3%), and lower TAR, TBR, and CV, with heterogeneity between studies. The increase in TIR was significant and robust independently of diabetes type, method of insulin delivery, and reason for CGM use. In preplanned subgroup analyses, real-time CGM led to the higher improvement in mean HbA1c (WMD –0.23%, 95% CI –0.36 to –0.10, P < 0.001), TIR (WMD 83.49 min, 95% CI 52.68–114.30, P < 0.001), and TAR, whereas both intermittently scanned CGM and sensor-augmented pump were associated with the greater decline in TBR. LIMITATIONS Heterogeneity was high for most of the study outcomes; all studies were sponsored by industry, had short duration, and used an open-label design. CONCLUSIONS CGM improves glycemic control by expanding TIR and decreasing TBR, TAR, and glucose variability in both type 1 and type 2 diabetes. Full Article
automobile Evaluation of Factors Related to Glycemic Management in Professional Cyclists With Type 1 Diabetes Over a 7-Day Stage Race By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE To investigate factors related to glycemic management among members of a professional cycling team with type 1 diabetes over a 7-day Union Cycliste Internationale World Tour stage race. RESEARCH DESIGN AND METHODS An observational evaluation of possible factors related to glycemic management and performance in six male professional cyclists with type 1 diabetes (HbA1c 6.4 ± 0.6%) during the 2019 Tour of California. RESULTS In-ride time spent in euglycemia (3.9–10.0 mmol/L glucose) was 63 ± 11%, with a low percentage of time spent in level 1 (3.0–3.9 mmol/L; 0 ± 1% of time) and level 2 (<3.0 mmol/L; 0 ± 0% of time) hypoglycemia over the 7-day race. Riders spent 25 ± 9% of time in level 1 (10.1–13.9 mmol/L) and 11 ± 9% in level 2 (>13.9 mmol/L) hyperglycemia during races. Bolus insulin use was uncommon during races, despite high carbohydrate intake (76 ± 23 g ⋅ h–1). Overnight, the riders spent progressively more time in hypoglycemia from day 1 (6 ± 12% in level 1 and 0 ± 0% in level 2) to day 7 (12 ± 12% in level 1 and 2 ± 4% in level 2) (2[1] > 4.78, P < 0.05). CONCLUSIONS Professional cyclists with type 1 diabetes have excellent in-race glycemia, but significant hypoglycemia during recovery overnight, throughout a 7-day stage race. Full Article
automobile Intrahepatic Fat and Postprandial Glycemia Increase After Consumption of a Diet Enriched in Saturated Fat Compared With Free Sugars By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE Debate continues regarding the influence of dietary fats and sugars on the risk of developing metabolic diseases, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). We investigated the effect of two eucaloric diets, one enriched with saturated fat (SFA) and the other enriched with free sugars (SUGAR), on intrahepatic triacylglycerol (IHTAG) content, hepatic de novo lipogenesis (DNL), and whole-body postprandial metabolism in overweight males. RESEARCH DESIGN AND METHODS Sixteen overweight males were randomized to consume the SFA or SUGAR diet for 4 weeks before consuming the alternate diet after a 7-week washout period. The metabolic effects of the respective diets on IHTAG content, hepatic DNL, and whole-body metabolism were investigated using imaging techniques and metabolic substrates labeled with stable-isotope tracers. RESULTS Consumption of the SFA diet significantly increased IHTAG by mean ± SEM 39.0 ± 10.0%, while after the SUGAR diet IHTAG was virtually unchanged. Consumption of the SFA diet induced an exaggerated postprandial glucose and insulin response to a standardized test meal compared with SUGAR. Although whole-body fat oxidation, lipolysis, and DNL were similar following the two diets, consumption of the SUGAR diet resulted in significant (P < 0.05) decreases in plasma total, HDL, and non-HDL cholesterol and fasting β-hydroxybutyrate plasma concentrations. CONCLUSIONS Consumption of an SFA diet had a potent effect, increasing IHTAG together with exaggerating postprandial glycemia. The SUGAR diet did not influence IHTAG and induced minor metabolic changes. Our findings indicate that a diet enriched in SFA is more harmful to metabolic health than a diet enriched in free sugars. Full Article
automobile Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is a known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated the association among prediabetes, type 2 diabetes, and measures of glycemia and HRV. RESEARCH DESIGN AND METHODS In the population-based Maastricht Study (n = 2,107; mean ± SD age 59 ± 8 years; 52% men; normal glucose metabolism [n = 1,226], prediabetes [n = 331], and type 2 diabetes [n = 550, oversampled]), we determined 24-h electrocardiogram-derived HRV in time and frequency domains (individual z-scores, based upon seven and six variables, respectively). We used linear regression with adjustments for age, sex, and major cardiovascular risk factors. RESULTS After adjustments, both time and frequency domain HRV were lower in prediabetes and type 2 diabetes as compared with normal glucose metabolism (standardized β [95% CI] for time domain: –0.15 [–0.27; –0.03] and –0.34 [–0.46; –0.22], respectively, P for trend <0.001; for frequency domain: –0.14 [–0.26; –0.02] and –0.31 [–0.43; –0.19], respectively, P for trend <0.001). In addition, 1-SD higher glycated hemoglobin, fasting plasma glucose, and 2-h postload glucose were associated with lower HRV in both domains (time domain: –0.16 [–0.21; –0.12], –0.16 [–0.21; –0.12], and –0.15 [–0.20; –0.10], respectively; frequency domain: –0.14 [–0.19; –0.10], –0.14 [–0.18; –0.09], and –0.13 [–0.18; –0.08], respectively). CONCLUSIONS Both prediabetes and type 2 diabetes were independently associated with lower HRV. This is further substantiated by independent continuous associations between measures of hyperglycemia and lower HRV. These data strongly suggest that cardiac autonomic dysfunction is already present in prediabetes. Full Article
automobile Underweight Increases the Risk of End-Stage Renal Diseases for Type 2 Diabetes in Korean Population: Data From the National Health Insurance Service Health Checkups 2009-2017 By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE There is a controversy over the association between obesity and end-stage renal disease (ESRD) in people with or without type 2 diabetes; therefore, we examined the effect of BMI on the risk of ESRD according to glycemic status in the Korean population. RESEARCH DESIGN AND METHODS The study monitored 9,969,848 participants who underwent a National Health Insurance Service health checkup in 2009 from baseline to the date of diagnosis of ESRD during a follow-up period of ~8.2 years. Obesity was categorized by World Health Organization recommendations for Asian populations, and glycemic status was categorized into the following five groups: normal, impaired fasting glucose (IFG), newly diagnosed diabetes, diabetes <5 years, and diabetes ≥5 years. RESULTS Underweight was associated with a higher risk of ESRD in all participants after adjustment for all covariates. In the groups with IFG, newly diagnosed type 2 diabetes, diabetes duration <5 years, and diabetes ≥5 years, the hazard ratio (HR) of the underweight group increased with worsening glycemic status (HR 1.431 for IFG, 2.114 for newly diagnosed diabetes, 4.351 for diabetes <5 years, and 6.397 for diabetes ≥5 years), using normal weight with normal fasting glucose as a reference. The adjusted HRs for ESRD were also the highest in the sustained underweight group regardless of the presence of type 2 diabetes (HR 1.606 for nondiabetes and 2.14 for diabetes). CONCLUSIONS Underweight showed more increased HR of ESRD according to glycemic status and diabetes duration in the Korean population. These associations also persisted in the group with sustained BMI during the study period. Full Article
automobile Diabetes, Cognitive Decline, and Mild Cognitive Impairment Among Diverse Hispanics/Latinos: Study of Latinos-Investigation of Neurocognitive Aging Results (HCHS/SOL) By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE Hispanics/Latinos are the largest ethnic/racial group in the U.S., have the highest prevalence of diabetes, and are at increased risk for neurodegenerative disorders. Currently, little is known about the relationship between diabetes and cognitive decline and disorders among diverse Hispanics/Latinos. The purpose of this study is to clarify these relationships in diverse middle-aged and older Hispanics/Latinos. RESEARCH DESIGN AND METHODS The Study of Latinos–Investigation of Neurocognitive Aging (SOL-INCA) is an ancillary study of the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability-sampled (i.e., representative of targeted populations), and prospective cohort study. Between 2016 and 2018, SOL-INCA enrolled diverse Hispanics/Latinos aged ≥50 years (n = 6,377). Global cognitive decline and mild cognitive impairment (MCI) were the primary outcomes. RESULTS Prevalent diabetes at visit 1, but not incident diabetes at visit 2, was associated with significantly steeper global cognitive decline (βGC = –0.16 [95% CI –0.25; –0.07]; P < 0.001), domain-specific cognitive decline, and higher odds of MCI (odds ratio 1.74 [95% CI 1.34; 2.26]; P < 0.001) compared with no diabetes in age- and sex-adjusted models. CONCLUSIONS Diabetes was associated with cognitive decline and increased MCI prevalence among diverse Hispanics/Latinos, primarily among those with prevalent diabetes at visit 1. Our findings suggest that significant cognitive decline and MCI may be considered additional disease complications of diabetes among diverse middle-aged and older Hispanics/Latinos. Full Article
automobile The Prognosis of Patients With Type 2 Diabetes and Nonalbuminuric Diabetic Kidney Disease Is Not Always Poor: Implication of the Effects of Coexisting Macrovascular Complications (JDDM 54) By care.diabetesjournals.org Published On :: 2020-04-20T12:00:33-07:00 OBJECTIVE Nonalbuminuric diabetic kidney disease (DKD) has become the prevailing phenotype in patients with type 2 diabetes. However, it remains unclear whether its prognosis is poorer than that of other DKD phenotypes. RESEARCH DESIGN AND METHODS A total of 2,953 Japanese patients with type 2 diabetes and estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2, enrolled in an observational cohort study in 2004, were followed until 2015. On the basis of albuminuria (>30 mg/g creatinine) and reduced eGFR (<60 mL/min/1.73 m2) at baseline, participants were classified into the four DKD phenotypes—no-DKD, albuminuric DKD without reduced eGFR, nonalbuminuric DKD with reduced eGFR, and albuminuric DKD with reduced eGFR—to assess the risks of mortality, cardiovascular disease (CVD), and renal function decline. RESULTS During the mean follow-up of 9.7 years, 113 patients died and 263 developed CVD. In nonalbuminuric DKD, the risks of death or CVD were not higher than those in no-DKD (adjusted hazard ratio 1.02 [95% CI 0.66, 1.60]) and the annual decline in eGFR was slower than in other DKD phenotypes. The risks of death or CVD in nonalbuminuric DKD without prior CVD were similar to those in no-DKD without prior CVD, whereas the risks in nonalbuminuric DKD with prior CVD as well as other DKD phenotypes were higher. CONCLUSIONS Nonalbuminuric DKD did not have a higher risk of mortality, CVD events, or renal function decline than the other DKD phenotypes. In nonalbuminuric DKD, the presence of macrovascular complications may be a main determinant of prognosis rather than the renal phenotype. Full Article
