global

Opportunities and Challenges for Biosimilars: What's on the Horizon in the Global Insulin Market?

Lisa S. Rotenstein
Oct 1, 2012; 30:138-150
Features




global

Migration, Development, and Global Governance: From Crisis toward Consolidation

Migration and development policy discussions have edged closer to each other on the international stage. The adoption of the Global Compact for Migration in December 2018 marks an important milestone. As all eyes turn toward the compact’s implementation, this brief examines some of the key topics states have pledged to work more closely on—from labor migration and migrants’ rights, to returns and reintegration.




global

Globalization of Diabetes: The role of diet, lifestyle, and genes

Frank B. Hu
Jun 1, 2011; 34:1249-1257
Kelly West Award Lecture




global

Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030

Christian Bommer
May 1, 2018; 41:963-970
The Costs Of Diabetes




global

Globalization of Diabetes: The role of diet, lifestyle, and genes

Frank B. Hu
Jun 1, 2011; 34:1249-1257
Kelly West Award Lecture




global

As COVID-19 Slows Human Mobility, Can the Global Compact for Migration Meet the Test for a Changed Era?

The coronavirus pandemic dramatically reshaped how human mobility is managed just as the Global Compact for Safe, Orderly, and Regular Migration was beginning to move from paper to implementation. As governments face pressing public-health, economic, and other concerns in responding to COVID-19, this MPI Europe commentary explores whether the first comprehensive global agreement on migration can adjust to a changed reality.




global

Global Dental Relief recruiting volunteers

Global Dental Relief, a nonprofit organization that has delivered free dental care to children around the globe since 2001, is seeking clinical volunteers for upcoming humanitarian missions in Nepal and Guatemala.




global

Global warming fuels algal bloom disrupting fisheries in Arabian Sea

A new scientific study published Monday found that global warming is fueling a destructive algal bloom that is disrupting fisheries in the Arabian sea.




global

Trade can spread economic toll of local disasters globally, study finds

Damage from a natural disaster in one place can spread globally due to urban trade networks, a Yale study said Monday.




global

Wetter climate to trigger global warming feedback loop in the tropics

As the tropics get wetter, soils are likely experience greater rates of respiration and decomposition, limiting the carbon storage abilities of tropical soils and intensifying global warming.




global

As Global Refugee Forum approaches, MPI Europe brief offers a road map for smart investment in refugee sponsorship programmes

BRUSSELS — Even as the number of refugees in need of protection has reached an all-time high, the resettlement spots offered by countries in 2018 were less than half the level in 2016—and future commitments may shrink further. With refugee needs high and generosity dimming, there is increasing urgency for humanitarian actors to find new ways to bring refugees to safety as well as to rebuild public interest and consensus around the importance of protection.




global

Global Demand for Medical Professionals Drives Indians Abroad Despite Acute Domestic Health-Care Worker Shortages

India is the world's largest source for immigrant physicians, and for Indian-trained doctors and nurses the allure of working abroad is strong despite an acute domestic shortage of health-care workers. Against this pull, the Indian government has enacted a number of policies to limit and regulate the emigration of health-care professionals, though these have been more ad hoc in nature and not part of a fully realized strategy.




global

Refugee Sponsorship Programs: A Global State of Play and Opportunities for Investment

From Argentina to New Zealand and points beyond, a growing number of countries have begun exploring refugee sponsorship as a way to expand protection capacity at a time of rising need, involving individuals and communities more directly in resettlement. This brief takes stock of what both new and well-established programs need to succeed, and outlines opportunities for private philanthropic actors to support them.




global

Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance

OBJECTIVE

Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study.

RESEARCH DESIGN AND METHODS

The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic 18F-fluorodeoxyglucose positron emission tomography combined with a euglycemic-hyperinsulinemic clamp in 30 volunteers without coronary artery disease. Three groups were studied: 1) those with 1-h postload glucose <155 mg/dL (NGT 1-h low) (n = 10), 2) those with NGT 1-h high (n = 10), 3) and those with IGT (n = 10).

RESULTS

After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; P = 0.024) and those with IGT (16.4 ± 6.0 mmol/min/100 mg; P < 0.0001) exhibited a significant reduction in global myocardial MRGlu; this value was 32.8 ± 9.7 mmol/min/100 mg in subjects with NGT 1-h low. Univariate correlations showed that MRGlu was positively correlated with insulin-stimulated whole-body glucose disposal (r = 0.441; P = 0.019) and negatively correlated with 1-h (r = –0.422; P = 0.025) and 2-h (r = –0.374; P = 0.05) postload glucose levels, but not with fasting glucose.

CONCLUSIONS

This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high.




global

Opportunities and Challenges for Biosimilars: What's on the Horizon in the Global Insulin Market?

Lisa S. Rotenstein
Oct 1, 2012; 30:138-150
Features




global

A global hackathon to take on the coronavirus pandemic | Marko Russiver

Looking to put your skills to use to fight the pandemic? Consider joining The Global Hack, a virtual hackathon designed to rapidly develop solutions to the coronavirus crisis. Designer and technologist Marko Russiver shares the motivation behind a movement looking to help people build post-pandemic resilience. (This virtual conversation is part of the TED Connects series, hosted by head of curation Helen Walters. Recorded April 8, 2020)




global

What coronavirus means for the global economy | Ray Dalio

"I'm a capitalist. I believe in the system. I believe you can increase the size of the pie and you could divide it well," says Ray Dalio, founder of Bridgewater Associates. He offers wide-ranging insight and advice on how we might recover from the global economic fallout of the coronavirus crisis -- and use it as an opportunity to reform the systems that help grow our economy. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and business curator Corey Hajim. Recorded April 8, 2020)




global

A global pandemic calls for global solutions | Larry Brilliant

Examining the facts and figures of the coronavirus outbreak, epidemiologist Larry Brilliant evaluates the global response in a candid interview with head of TED Chris Anderson. Brilliant lays out a clear plan to end the pandemic -- and shows why, to achieve it, we'll have to work together across political and geographical divides. "This is not the zombie apocalypse; this is not a mass extinction event," he says. "We need to be the best version of ourselves." (Recorded April 22, 2020)




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Researchers Once Found That People Believe In “Climate Change” More Than “Global Warming” — But Word Choice No Longer Seems To Matter

By Jesse Singal. Study fails to replicate 2011 result, suggesting that word choice matters less as issue has become more politicised.




global

Revisiting the forum non-convenience and inappropriate forum / paper presented by Dr Ricky J. Lee, Globalex Tax & Legal.




global

All the boats on the ocean : how government subsidies led to global overfishing / Carmel Finley.

Fishery management -- United States -- History -- 20th century.




global

Global discontents : conversations on the rising threats to democracy / Noam Chomsky ; interviews with David Barsamian.

Chomsky, Noam -- Political and social views.




global

The house of Islam : a global history / Ed Husain.

Muslims.




global

Global meat : social and environmental consequences of the expanding meat industry / edited by Bill Winders and Elizabeth Ransom.

Meat industry and trade -- Environmental aspects.




global

Secondhand : travels in the new global garage sale / Adam Minter.

Minter, Adam, 1970- -- Travel.




global

Globalizing capital : a history of the international monetary system

Eichengreen, Barry J., author.
9780691193908 (paperback)




global

A Global Benchmark of Algorithms for Segmenting Late Gadolinium-Enhanced Cardiac Magnetic Resonance Imaging. (arXiv:2004.12314v3 [cs.CV] UPDATED)

Segmentation of cardiac images, particularly late gadolinium-enhanced magnetic resonance imaging (LGE-MRI) widely used for visualizing diseased cardiac structures, is a crucial first step for clinical diagnosis and treatment. However, direct segmentation of LGE-MRIs is challenging due to its attenuated contrast. Since most clinical studies have relied on manual and labor-intensive approaches, automatic methods are of high interest, particularly optimized machine learning approaches. To address this, we organized the "2018 Left Atrium Segmentation Challenge" using 154 3D LGE-MRIs, currently the world's largest cardiac LGE-MRI dataset, and associated labels of the left atrium segmented by three medical experts, ultimately attracting the participation of 27 international teams. In this paper, extensive analysis of the submitted algorithms using technical and biological metrics was performed by undergoing subgroup analysis and conducting hyper-parameter analysis, offering an overall picture of the major design choices of convolutional neural networks (CNNs) and practical considerations for achieving state-of-the-art left atrium segmentation. Results show the top method achieved a dice score of 93.2% and a mean surface to a surface distance of 0.7 mm, significantly outperforming prior state-of-the-art. Particularly, our analysis demonstrated that double, sequentially used CNNs, in which a first CNN is used for automatic region-of-interest localization and a subsequent CNN is used for refined regional segmentation, achieved far superior results than traditional methods and pipelines containing single CNNs. This large-scale benchmarking study makes a significant step towards much-improved segmentation methods for cardiac LGE-MRIs, and will serve as an important benchmark for evaluating and comparing the future works in the field.




global

Joint Multi-Dimensional Model for Global and Time-Series Annotations. (arXiv:2005.03117v1 [cs.LG])

Crowdsourcing is a popular approach to collect annotations for unlabeled data instances. It involves collecting a large number of annotations from several, often naive untrained annotators for each data instance which are then combined to estimate the ground truth. Further, annotations for constructs such as affect are often multi-dimensional with annotators rating multiple dimensions, such as valence and arousal, for each instance. Most annotation fusion schemes however ignore this aspect and model each dimension separately. In this work we address this by proposing a generative model for multi-dimensional annotation fusion, which models the dimensions jointly leading to more accurate ground truth estimates. The model we propose is applicable to both global and time series annotation fusion problems and treats the ground truth as a latent variable distorted by the annotators. The model parameters are estimated using the Expectation-Maximization algorithm and we evaluate its performance using synthetic data and real emotion corpora as well as on an artificial task with human annotations




global

In china's wake : how the commodity boom transformed development strategies in the global south

Jepson, Nicholas, author.
9780231547598 electronic book




global

Handbook of Global Health

9783030053253 978-3-030-05325-3




global

Almost sure uniqueness of a global minimum without convexity

Gregory Cox.

Source: The Annals of Statistics, Volume 48, Number 1, 584--606.

Abstract:
This paper establishes the argmin of a random objective function to be unique almost surely. This paper first formulates a general result that proves almost sure uniqueness without convexity of the objective function. The general result is then applied to a variety of applications in statistics. Four applications are discussed, including uniqueness of M-estimators, both classical likelihood and penalized likelihood estimators, and two applications of the argmin theorem, threshold regression and weak identification.





global

New Engineering X Pandemic Preparedness programme to support global innovation and knowledge sharing




global

The quest for financial integration in Europe and globally

Speech by Mr Agustín Carstens, General Manager of the BIS, at the Eurofi Financial Forum, Helsinki, 12 September 2019.




global

A tale of two financial cycles: domestic and global

Lecture by Claudio Borio, Head of the Monetary and Economic Department, at the University of Zürich, Zürich, 19 November 2019.




global

Mothers and children hold the key to better global nutrition

In the past 20 years, malnutrition in mothers and children has decreased by almost half. But despite this progress, child undernutrition is still the greatest nutrition-related health burden in the world. One of the biggest problems with child undernutrition is that it continues the cycle of stunting: stunted girls grow up to be stunted mothers, and stunted mothers are much [...]




global

Introducing TARGET: #ZeroHunger, FAO's new podcast series on global food issues

Radio culture is gaining more and more ground as millions of listeners take to audio podcasts as a convenient and accessible way to learn new information.  Which is why FAO is stepping up into the medium to bring you insights into some of the issues concerning food and agriculture worldwide. Here are the first seven audio offerings of FAO’s new podcast [...]




global

Expected loss provisioning under a global pandemic

FSI Briefs No 3, April 2020. In response to the 2007-09 Great Financial Crisis (GFC), accounting standard setters introduced a new methodology to value loans based on expected credit losses (ECL). The previous approach, based on incurred losses, was viewed as procyclical and inconsistent with prudential objectives. In the wake of the Covid-19 pandemic, several prudential authorities and the Basel Committee on Banking Supervision (BCBS), introduced a series of measures to clarify how banks should consider various public and private debt relief programmes in their ECL estimates and in their calculation of regulatory capital. These measures are intended to incentivise banks to continue supporting the real economy, while reducing pressure on banks' ECL provisions, earnings and regulatory capital. Supervisory initiatives that provide capital relief should be augmented by severe constraints on the payment of dividends, bonuses and share buybacks. These joint actions will simultaneously expand banks' lending capacity and enhance their ability to absorb losses. Prudential authorities face difficult trade-offs as they confront the most severe economic crisis in modern times. Encouraging the use of flexibility in applicable accounting standards, while preserving market trust and transparency in the reported financial statements of banks, will be key in fostering both economic and financial stability.




global

Dollar invoicing, global value chains, and the business cycle dynamics of international trade

Recent literature has highlighted that international trade is mostly priced in a few key vehicle currencies, and is increasingly dominated by intermediate goods and global value chains (GVCs). Taking these features into account, this paper reexamines the business cycle dynamics of international trade and its relationship with monetary policy and exchange rates.




global

Markets Committee calls for wider adoption of global code of conduct for foreign exchange markets

Markets Committee calls for wider adoption of global code of conduct for foreign exchange markets (Press release, 30 January 2020)




global

No global real estate market despite higher price synchronisation and growing role of international investors, central banks find

No global real estate market despite higher price synchronisation and growing role of international investors, central banks find (Press release, 18 February 2020)




global

Saudi G20 Presidency and the Bank for International Settlements (BIS) Innovation Hub invite global innovators to find solutions to the most pressing financial regulatory &amp; supervisory challenges

Press release "Saudi G20 Presidency and the Bank for International Settlements (BIS) Innovation Hub invite global innovators to solve RegTech and SupTech challenges", 27 April 2020




global

BIS global liquidity indicators at end-June 2019

US dollar credit to non-bank borrowers outside the United States grew by 4% year on year at end-June 2019, to reach $11.9 trillion. Foreign currency credit denominated in euros and Japanese yen continued to expand at a faster pace than that in US dollars, growing at annual rates of 9% and 8%, respectively. US dollar credit to emerging market and developing economies (EMDEs) grew at an annual rate of 2% (to reach $3.7 trillion), though growth varied substantially across regions.




global

BIS global liquidity indicators at end-September 2019

US dollar credit to non-bank borrowers outside the United States grew by 5% year on year at end-September 2019, to reach $12.1 trillion. Euro-denominated credit outside the euro area continued to expand at a fast pace (9%). In contrast, the growth rate of yen-denominated credit outside Japan fell to 1%. Strong debt securities issuance drove expansions in US dollar and euro credit to emerging market and developing economies (EMDEs). US dollar credit to EMDEs grew at an annual rate of 3% (to reach $3.8 trillion); euro credit to EMDEs expanded by 9% (to reach €0.7 trillion).




global

BIS global liquidity indicators at end-December 2019

US dollar credit to non-bank borrowers outside the United States grew by 6% in 2019, to reach $12.2 trillion at end-2019. The annual growth rate of euro-denominated credit outside the euro area slowed to 6%, while that of yen-denominated credit outside Japan turned negative (-1%). In 2019, euro-denominated credit overtook US dollar-denominated credit as the largest stock of foreign currency credit to emerging Europe. The debt securities share in US dollar credit outside the United States has risen considerably over the past decade across a number of major borrowing regions.




global

Global liquidity indicators

The term global liquidity is used by the BIS to mean the ease of financing in global financial markets. Credit is among the key indicators of global liquidity, and is the focus of the quarterly indicators estimated by the BIS.




global

Learning the value of resilience and technology: the global financial system after Covid-19

Remarks by Benoît Cœuré, Head of the Bank for International Settlements Innovation Hub, at the Reinventing Bretton Woods Committee - Chamber of Digital Commerce webinar on "The world economy transformed", 17 April 2020.




global

Olli Rehn: A globally symmetric crisis calls for a globally coordinated and forceful policy response

Remarks by Mr Olli Rehn, Governor of the Bank of Finland, at the Reinventing Bretton Woods Committee Panel Discussion on "The world economy transformed: Reflections on policy responses and the future post pandemic monetary architecture", in the context of the virtual IMF Spring Meetings, Washington DC, 17 April 2020.




global

FIRST Global Challenge Dubai Inspires STEM Students and the World

Great challenges face our planet.  Today’s students will solve our biggest problems.  The FIRST Global Challenge is a Science, Technology, Engineering and Math (STEM) Olympic – like competition that showcases students’  abilities to solve one of the 14 Grand Challenges

Author information

Director of Education & Early Engagement, SolidWorks at Dassault Systemes SolidWorks Corporation

Marie Planchard is an education and engineering advocate. As Senior Director of Education & Early Engagement, SOLIDWORKS, she is responsible for global development of content and social outreach for the 3DEXPERIENCE Works products across all levels of learning including educational institutions, Fab Labs, and entrepreneurship.

The post FIRST Global Challenge Dubai Inspires STEM Students and the World appeared first on SOLIDWORKS Education Blog.




global

Mastering SOLIDWORKS Visualize and Creating the FIRST Global Challenge Field

In this blog by intern Ben, he explains how to learn and master SOLIDWORKS Visualize

Author information

Ben Horton

I am an intern and a mentor in the 3DEXPERIENCE Lab here at the DASSAULT SYSTEMS Waltham campus. Currently I am studying Mechanical Engineering at the University of Massachusetts, Lowell. I am also the Vice-President of the Society of Automotive Engineers at UMass Lowell. My interests include building racecars, petting dogs, being a maker, and going on adventures in my Outback!

The post Mastering SOLIDWORKS Visualize and Creating the FIRST Global Challenge Field appeared first on SOLIDWORKS Education Blog.