Jerry’s Abra Auto Body and Glass, owned by the Kottschade family, has been partnering with the Mankato Moondogs, a summer collegiate baseball team, has partnered with Jerry’s Abra Auto Body and Glass each season since 2017, with the business donating $100 to the Alzheimer’s Association for every home run the team hits. With 38 home […]

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While growing evidence suggests that there’s a link between blood iron levels and the development of Alzheimer’s disease, new research investigating the effects of an available iron-reducing drug has raised concerns about its use as a treatment for the condition.

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Category: Alzheimer's & Dementia, Brain Health, Body & Mind

Tags: Iron, clinical trials, Alzheimer's disease

The charity had supported almost 100,000 people living with dementia and had a record fundraising year

By 2060, nearly 14 million people in the U.S. will be living with dementia, including Alzheimer’s disease. A new report charts a course for the next 10 years of research in the behavioral and social sciences that can point to possible pathways for slowing or preventing dementia and easing its social and economic impacts.

Data-share this, pal: As the man said, you have no obligation to share any of your data and I have no obligation to believe anything you say.

Genetic tests showed that certain patients were predisposed to brain injuries if they took the drugs. That information remained secret.

Cerebrospinal fluid proteomics in patients with Alzheimer’s disease reveals five molecular subtypes with distinct genetic risk profiles  Nature.com

Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology  Nature.com

Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies  Nature.com

Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease  Nature.com

Serum proteomics reveal APOE-ε4 -dependent and APOE-ε4 -independent protein signatures in Alzheimer’s disease  Nature.com

A new drug that slows the pace of Alzheimer's disease is too expensive for too little benefit to be used on the NHS, the watchdog says.

Oct. 25, 2024 — Aggregation of proteins underlies many human disorders, including Alzheimer’s. Teams from the New Jersey Institute of Technology and Princeton University joined forces to study how the amyloid […]

The post PSC: Anton Simulations Reveal How Alzheimer’s Fibril Growth May Accelerate appeared first on HPCwire.

Promising new vaccines are designed to be given to patients at risk of developing Alzheimer's disease. If they perform well in clinical trials, they have the potential to one day rid society of dementia

Promising new vaccines are designed to be given to patients at risk of developing Alzheimer's disease. If they perform well in clinical trials, they have the potential to one day rid society of dementia

Produced by WIRED Brand Lab with Labcorp | One of the biggest challenges for people with Alzheimer’s Disease and their caregivers is the path to a correct diagnosis. Recent advancements in biomarker technology are about to change that by measuring neurodegeneration in the brain, differentiating Alzheimer’s from other forms of neurodegenerative disorders, and even producing a diagnosis years before symptoms appear. Dr. Marcia Eisenberg, Chief Scientific Officer at Labcorp, shares the development of these technologies and their implementation, physician and Professor of Neurology Dr. Marwan Sabbagh speaks to the impact of these advancements and Jamie Haendel shares her personal experience with the disease, as daughter and caregiver to Paula Haendel, a woman diagnosed with Alzheimer’s.

Alzheimer’s, a progressive form of dementia, may occur in middle age or in old age, and while a lot of research is on for drug treatments, none has been successful.

Researcher says the 'super fruit ' can have a real benefit in improving memory and cognitive function in some older adults

Such a probe can easily be fabricated into a strip-based kit that may enable on-site diagnosis

Study suggests activating PPAR receptor leads to increased cellular connections in hippocampus

An antibody called BAN2401 cleared amyloid-β proteins and slowed cognitive decline in people with mild Alzheimer’s disease

Kyoto University researchers said the vaccine for Alzheimer’s was effective and was also shown to have zero side effects observed in the mice.

The post New Alzheimer’s Nasal Spray Shown to Reduce Proteins Which Cause the Disease in Mice appeared first on Good News Network.

Arkaprava Roy, Subhashis Ghosal, Jeffrey Prescott, Kingshuk Roy Choudhury.

Source: The Annals of Applied Statistics, Volume 13, Number 3, 1791--1816.

Abstract:
We study possible relations between Alzheimer’s disease progression and the structure of the connectome which is white matter connecting different regions of the brain. Regression models in covariates including age, gender and disease status for the extent of white matter connecting each pair of regions of the brain are proposed. Subject inhomogeneity is also incorporated in the model through random effects with an unknown distribution. As there is a large number of pairs of regions, we also adopt a dimension reduction technique through graphon ( J. Combin. Theory Ser. B 96 (2006) 933–957) functions which reduces the functions of pairs of regions to functions of regions. The connecting graphon functions are considered unknown but the assumed smoothness allows putting priors of low complexity on these functions. We pursue a nonparametric Bayesian approach by assigning a Dirichlet process scale mixture of zero to mean normal prior on the distributions of the random effects and finite random series of tensor products of B-splines priors on the underlying graphon functions. We develop efficient Markov chain Monte Carlo techniques for drawing samples for the posterior distributions using Hamiltonian Monte Carlo (HMC). The proposed Bayesian method overwhelmingly outperforms a competing method based on ANCOVA models in the simulation setup. The proposed Bayesian approach is applied on a dataset of 100 subjects and 83 brain regions and key regions implicated in the changing connectome are identified.

As part of National Alzheimer’s Awareness Month, the Delaware Division of Public Health (DPH) urges Delawareans to make lifestyle adjustments to help reduce their risk factors for Alzheimer’s and dementia.

Despite clinical trial failures, Alzheimer’s research is getting a reboot thanks to increased funding opportunities and new directions in the data.

Study suggests activating PPAR receptor leads to increased cellular connections in hippocampus

An antibody called BAN2401 cleared amyloid-β proteins and slowed cognitive decline in people with mild Alzheimer’s disease