An Engineer's View (EV) wireless video system for powered and unpowered model railroad engines is disclosed. The invention uses commercially available wireless spy cameras, powered by a custom power supply circuit which is compatible with either DC or DCC track systems. The present invention is compatible with all commercial model railroad gauge diesel engines including HO and N Gauge or may be factory installed. The EV system demonstrates a remarkably stable and realistic image of a model railroad layout. Moreover, the present invention may also provide a stable source of power to the engine where stalling could occur at points of track defects.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

The present disclosure provides compositions and methods of use involving binding proteins, e.g., antibodies and antigen-binding fragments thereof, that bind to the matrix metalloproteinase-9 (MMP9) protein (MMP9 is also known as gelatinase-B), such as where the binding proteins comprise an immunoglobulin (Ig) heavy chain (or functional fragment thereof) and an Ig light chain (or functional fragment thereof).

The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.

The nurse's travel bag is a travel bag or suitcase for storing a plurality of medical devices and/or supplies that a nurse may need. The nurse's travel bag includes a suitcase with a plurality of compartments integrated inside of and along the exterior of the suitcase. Each storage compartment consists of a clear plastic storage compartment, an identifying label, and a zipper for opening and closing said compartment. The suitcase may include rollers and a telescoping handle, which enable rolling of said suitcase. The suitcase includes a collapsible cooler and sharps container that extend from opposing side surfaces, and enable storage therein.

Apparatus (2) for exercising a person's calves (4) in two different ways, which apparatus (2) comprises a footrest (8), a kneerest (10), and a length of stretchable material (12) for extending between the footrest (8) and the kneerest (10), and the apparatus (2) being such that: (i) the length of stretchable material (12) is flat sided;(ii) the footrest (8) has roller means (14);(iii) the roller means (14) allows the length of stretchable material (12) to connect to the footrest (8) such that the flat sides of the length of stretchable material (12) slide over the roller means (16);(iv) the kneerest (10) has anchor means (16) for the length of stretchable material (12);(v) the anchor means (16) allows the length of stretchable material (12) to connect to the kneerest (10) such that the flat sides of the length of stretchable material (12) pass over the anchor means (16); and(vi) the footrest (8), the kneerest (10), and the length of flexible material (12) are separable from each other.

A method for processing explosives containing a high loading of CL-20 may advantageously include a binder system having naphthenic oil and/or paraffinic oil. Solid energetic ingredients are added into the binder system and mixed to form a free-flowing suspension in which the solid energetic ingredients are homogeneously mixed and coated with the binder system. The binder system is then cured and cast to form a cross-linked explosive.

The small clothes iron for use with children's clothes is a small iron when compared to a traditional clothes iron. The small clothes iron resembles a toy train wherein a front surface resembles a face of a toy character while a top surface includes a handle, control buttons, and a chimney/smokestack for refilling a water reservoir. The small clothes iron has a smaller iron surface on a bottom surface, which is useful in ironing small clothes for children and infants.

A mechanic's leaning device includes a base, an upper torso support having an adjustable first height above the base, and a combination step and knee support having an adjustable second height above the base which is less than and adjustable relative to the first height. The mechanic's leaning device can be used by mechanics of all sizes for working on a wide variety of vehicles, ranging from very small to very large.

A restraining system is configured to secure and release a rider's footwear to a vehicle footrest in response to inputs to a control interface. The vehicle is typically a motorcycle or bicycle. In the case of a motorcycle, a rider's boot is restrained to a motorcycle foot peg by the action of a restraining device. Exemplary restraining device embodiments include an electromagnet or a mechanical latch. The control interface may be located on the motorcycle handlebar or on the rider's helmet. The rider can provide the inputs directly to the control interface. Alternatively, the inputs may be received from a wireless source.

Described herein is an arm stabilization member for dampening inadvertent movement of the arm of a user during a surgical procedure, comprising an arm support and a movement mechanism coupled to the arm support. The arm support comprises an outer frame sized to support at least a portion of the user's arm and an inner pad lining an inner surface of the outer frame and configured to conform to the user's arm. The movement mechanism comprises a counterbalance system movably connected by joints and configured to compensate for the gravitational forces exerted by the arm of the user.

A patient support apparatus having a support table, a transfer plate, which is disposed movably in relation to the support table in a direction and on which a patient is supported for a surgical intervention and/or a medical imaging examination, and a surgical head restraint unit, which is disposed on the transfer plate is provided. The patient support apparatus includes a position monitoring apparatus for monitoring and/or checking a position of the surgical head restraint unit.

Hinged assemblies, and children's products including at least one hinged assembly, include a base member and a hinged member operatively and pivotally coupled to the base member to define a hinge. The hinge is configured to release if an obstruction is positioned between the hinged member and the base member while the hinged member is being closed and if a closing torque is greater than or equal to a release torque. The hinge also may be configured to not release when an opening torque is applied when the hinged member is in its open position even when the opening torque is greater than the release torque.

A hanger for a sash of a window to detachably engage the sash with a rail of the window, and the hanger includes a pulley assembly and a restricting assembly. The pulley assembly has a base and a plurality of pulleys mounted on the base for rotation. The pulleys engage the rail so that the pulley assembly moves in the rail. The base is provided with a slot. The sash is provided with a rod. The rod engages the slot of the pulley assembly to engage the sash with the rail, and the rod leaves the slot via a lateral opening thereof while the covering rotates for a predetermined angle. At this time, the sash is disengaged with the rail to be moved off the window.

The rapper revisits The Town through songs and videos on her new album,Got It Made East Oakland has a prismatic reputation. Though the mainstream media tends to focus on illegal sideshows or exaggerated tales of crime and lawlessness, local residents know East Oakland more for its barbecues, banging-ass parties, and friendly-though-struggling neighborhoods.…

An inflatable dummy target comprising a chassis of inflatable ducts wrapped with a sheet. The chassis of inflatable ducts can include one or more ring shaped ducts and one or more elongate ducts. The chassis can include at least two ring shaped ducts interconnected by one or more elongate ducts. The dummy target can include several attached axi-symmetrical sections, each section have a chassis of inflatable ducts. Each section can be conical, frustoconical or cylindrical, thereby achieving a concave or convex dummy target geometry.

The Damn Virus: Local governments await budget slaughter; supes to investigate county hospital. Local governments across the East Bay are now entering budget season. Alameda County Administrator Susan Muranishi is expected to provide the Board of Supervisors with an update on the Fiscal Year 2020-21 budget this week.…

Fremont high school student Araav Patel has got you covered. Plus, union says whistblower fired, and governor plans for the end of lockdown. Araav Patel lives in a household containing several people at greater risk from COVID-19. The Fremont high school student lives with his parents and grandparents, and suffers personally from a heart condition.…

It might just be a distinction without a difference. Is cannabis really an "essential" business? The food business obviously is. But the legal cannabis industry didn't exist a few years ago, while gathering and making food — contrary to the popular cliché about prostitution — is the world's oldest profession.…

A fabric assembly attachable to the front side of a men's underwear and a men's underwear having such a fabric assembly are described. The fabric assembly has layers of fabrics having linear slots perpendicular to each other so that the wearer can take his genital organ out through the intersection of the linear slots. The peripheries of the fabric layers are elastically stitched together to make a fabric assembly. The fabric layers have sufficient rigidity such that the linear slots do not open under the pressure of the genital organ, unless the wearer uses his hands to open the slots. The fabric assembly may also have a flap on the inside or outside of the fabric layers. One or two sides of the flap may be attached to the men's underwear and the other sides may not be attached to permit easy opening of the flap by hand.

Disclosed herein are methods for treating solid mass tumors with direct delivery of an anti-tumor immunotherapeutic agent to the tumor site. In one aspect, this invention encompasses methods of treating solid mass tumors by direct microinjection via a microcatheter of an anti-tumor immunotherapeutic agent into the microvasculature leading into tumor thereby providing high levels of contact with the tumor while minimizing the degree of systemic buildup of the immunotherapeutic agent.

Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep disorders, Parkinson's disease, Attention Deficit Disorder and nicotine addiction involve synchronizing and tailoring the administration of nutraceuticals, medications and other substances in accordance with the body's natural circadian rhythms, meal times and other factors. Improved control of blood glucose levels, extended alertness, and weight control, and counteracting of disease symptoms when they are at their worst are possible. An automated, pre-programmable transdermal administration system is used to provide pulsed doses of medications, pharmaceuticals, hormones, neuropeptides, anorexigens, pro-drugs, stimulants, nutraceuticals, phytochemicals, phytonutrients, enzymes, antioxidants, essential oils, fatty acids, minerals, vitamins, amino acids, coenzymes, or other physiological active ingredient or precursor. The system can utilize a pump, pressurized reservoir, a system for removing depleted carrier solution, or other modulated dispensing actuator, in conjunction with porous membranes or micro-fabricated structures.

Despite some growing pains, the fest successfully expanded into a ten-day concert series that highlighted outstanding local talent. Jay Stone looked at home as he took the stage in a burgundy bathrobe last Thursday at The Night Light, a bar near Jack London Square. He was headlining the seventh night of Oakland Music Festival, which dominated the local concert calendar from September 30 to October 9 with shows taking place at different venues every night.…

'Don’t build technology for Mordor.' On Saturday at Peter Thiel’s San Francisco home overlooking the Bay, protesters demonstrated against a collaboration between Immigration and Customs Enforcement and Palantir Technologies, a data-mining firm that Thiel co-founded. As reported in The Intercept, ICE will be using a new Palantir product called Investigative Case Management to to aid in its expanded deportation mission.…

Including a photo slideshow. Even at 10 a.m. this past Saturday morning, hours before a throng of anti-fascists and Trump-supporting white nationalists overtook downtown Berkeley’s streets, it was clear that most of the attendees were less interested in speeches, protesting, and free speech — and were mostly there just to tee-off on each other. Before the brawling began, officers stationed themselves at the entrances to downtown's "Peace Park."…

ACT for America, which the Southern Poverty Law Center has designated as an anti-muslim hate group, showed up on Saturday morning in cities nationwide, dubbing its protest a "March Against Sharia." Berkeley was spared, but the group appeared in nearby Santa Clara, and in Roseville, a suburb of Sacramento.…

Turf dancing has become ubiquitous on the trains, providing steady income, a creative platform, and a built-in audience. On a recent Friday, Yaameen Muhammad stood on the West Oakland BART platform, the afternoon sun reflecting off his neon-yellow high-tops.…

Here are photos from today's Warriors' championship parade.

The last time J Balvin was at Oracle arena was back on Feb. 15, 2015 when he was the opening act for Pitbull and Enrique Iglesias' joint tour. I was at that show with my mom as my date, and vividly remember her saying, “one day he’s going to headline his own tour here.” I brushed off her comment, it wasn’t that I didn’t believe that he was talented.…

With its thriving businesses and large immigrant population, Fruitvale is uniquely Oakland: diverse, welcoming, family-oriented, community-minded — and too-often overlooked. On a Saturday morning in November, an estimated 100,000 people flocked to Oakland's Fruitvale district along International Boulevard and a section of East 12th Street.…

The Richmond pop-up is a new contender for best fried chicken sandwich. There's no shortage of smog check stations on Richmond's 23rd Street, but on a sunny Saturday afternoon, a steady stream of cars piled into Super Star Smog's tiny parking lot, causing a minor traffic jam on the adjacent side street. On a Wednesday afternoon, an otherwise quiet industrial and residential Richmond street filled with cars, and people hastily headed into what appeared to be a warehouse (but was actually a motorcycle club).…

Oakland-based Cream Co. Meats announced recently that, for the first time ever, it will start delivering its products on a retail basis. Statewide Covid-19-related shelter-in-place regulations mandated the closure of many restaurants and other businesses that regularly serve and sell Cream Co. products.…

In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

Noted restaurateur Reem Assil has decided to close her Fruitvale restaurant, Reem's California.

"From the bottom of our hearts, we'd like to thank everyone who has supported us in keeping our humble oakland restaurant operation a force in our community.…

East Bay resident Miles Woodruff, CEO of the pioneering vegan-seafood brand Sophie's Kitchen, has just donated 3,000 cases of plant-based Toona to the Food Bank of Contra Costa and Solano County as well as several other Bay Area food shelters.

Amidst the Covid-19 outbreak, the company's brand-new Lemon Grass Toona flavor has not yet arrived in grocery stores — but 100 percent of it is now being provided to people in need.…

This month alone, Oakland-based, family-owned Mr. Espresso has already donated over 2,500 pounds of coffee to COVID-19 relief efforts all over the Bay Area.

During the first two weeks of April, the 42-year-old company — founded in Alameda by enterprising Italian-born Carlo Di Ruocco and now renowned as the first and currently only outfit in the nation that uses oak wood to roast its beans — has given coffee to the Alameda County Community Food Bank and San Francisco-Marin Food Bank, Frontline Foods, East Bay FeedER, Clinica de La Raza, St. Anthony’s Dining Room, Loaves and Fishes Family Kitchen, and other food-, health-, homeless-, youth-, and family-assistance programs.…

People for the Ethical Treatment of Animals sent UC Berkeley chancellor Carol Christ a letter today requesting permission to place a banner on the university's famous clocktower that reads "It's High Time We Went Vegan. PETA."…

The brick-and-mortar Fruitvale location of La Guerrera's Kitchen is now closed — permanently.

Mother-and-daughter owners Ofelia Barajas and Reyna Maldonado decided against negotiating a new lease for the restaurant when their previous one ended in March, as reported by the San Francisco Chronicle.

Instead, the pair will sell tamales online with pickups several days a week at the Ale Industries brewery.…

Now through May 5, healthcare workers and first responders can collect free "Thank You Meals" at any McDonald's location nationwide.

The promotion began on April 22.…

If you happen to run into any medical residents anytime soon, they may look a little fatigued and broke, especially if they happen to be residents or pediatricians of UCSF Benioff Children’s Hospital of Oakland. Today, the CIR/SEIU Healthcare union that represents resident physicians and pediatricians said it plans to rally in front of the hospital on Friday at 12:15 p.m. along with nurses and community leaders to demand better wagers and working conditions.…

The city's 911 system can leave callers waiting for more than 120 seconds before an operator ever answers. Seconds of delay in an emergency can lead to death. As a result, 911 calls are supposed to be answered quickly.…

I was wondering why the iconic Civic Centre clock in Southampton is not lit up blue on Thursday at 8pm to clap for the NHS.

CHRISTINE Cassell (letters 28th April) asks a pertinent question when she enquires where the responsibility for the problem with PPEs for front line NHS workers lies.

75 YEARS AGO this week St John Ambulance volunteers played a vital role delivering first aid and providing support to both the public and the armed forces on VE Day.

I SHOULD like to pay tribute to Alan Wiltshire the Echo and Romsey Advertiser reporter whose death was sadly announced last week

ONLY a delusional Lib Dem like Martin Kyrle could come up with an excuse like this about his beloved party doing well in the last election when in fact they lost over half their seats, then blaming it on our undemocratic electoral system, it’s the system we have, and our MP’s are elected on that system.

HE MAY NOT be held in the highest regard by the public but there’s something to love about Piers Morgan on Good Morning Britain.

More rose-tinted views of the EU: the EU not falling apart?

I say to all communities pat yourselves on the back for the great job you are doing taking care of each other and supporting each other.