The puppet's felt hair bounces as she stage-whispers to the other puppets, almost conspiratorially, about their plans.…

Every spring, audiences in Moscow are typically congregating for the Kino Short Film Festival, an evening of shorts made by the University of Idaho's senior film students. Things being as they are, the Kenworthy Theater won't be open for this year's event, but the U of I will be streaming a virtual version this Friday, May 8, at 6 pm.…

ON INLANDER.COM NATION: For workers, there's no sign of what "normal is going to look like" in the pandemic economy.…

If you go to check how many people are hospitalized with COVID-19 in Spokane, the Spokane County Regional Health District website will give you an answer. Right now, it lists eight people as currently hospitalized with COVID-19, and that number has been trending downward.…

Designology Interiors' Deanna Goguen has three bathrooms in her South Hill-area home, each with its own personality.…

Miang Goong Miang is the Thai version of lettuce wraps, in this case featuring goong, or shrimp.…

Q: I recently read that a combination of the drugs hydroxychloroquine and azithromycin might be effective against COVID-19. I have diabetes and I am at risk for this viral infection.…

POMPEII, THE IMMORTAL CITY is on exhibit at the MAC. But galleries that should be thronged with visitors are empty, at least for a while.…

The Inlander is a community newspaper covering news, politics, events, happy hour, everything that's happening today, things to do on the weekend, in Spokane, Coeur d'Alene, the greater Inland Northwest and beyond.

[IMAGE-1] The days of Post Falls being merely an exit you point out to your restless kids to assure them you're almost to Coeur d'Alene are over. In the next 20 years, the little town is projected to explode to 100,000 people.…

[IMAGE-1] Visiting Spokane Valley is a little like when a child visits their grandparents' place: At first you don't understand why you're there, but after you leave with new toys, clothes and a full stomach, you can't wait to go back. And the Spokane Valley Mall has all of that.…

The Showcase celebrity golf tournament attracts big-time athletes and pop stars each year.…

[IMAGE-1] It's not surprising the most popular destinations for Inlander readers in North Spokane involve shopping — NorthTown Mall and the Garland District were the top vote-getters in this year's poll — but looking at the overall results, one quickly realizes the region north of the river has a lot going on. Riverside State Park and the Little Spokane River were popular picks, too, along with Mt. Spokane Ski & Snowboard Park; clearly people love to get outside up north in between their trips to Bon Bon or Buffalo Wild Wings.…

[IMAGE-1] Midtown Coeur d'Alene. The pedestrian-friendly strip of restaurants and shops that runs north-south along Fourth Street in between Garden and Harrison avenues.…

For people who love playing, a day on the worst possible golf course is better than any day not swinging the clubs.…

[IMAGE-1] The people were unequivocal: The South Perry District and Manito Park are the most popular reasons to visit the South Hill, and for good reason. Manito Park is sprawling and beautiful, with 78 acres of native and cultivated landscape and 20 acres of botanical gardens.…

One great thing about seeing "oldies" acts on tour is the vivid reminder you get that groups in the old days really knew how to serve their fans. Take the Commodores, for example, a group with a 52-year-history that swung by Northern Quest Resort & Casino Thursday night.…

Every serious pinball player remembers their first machine.…

Mosey on up to the bar at Lil Sumthin' Saloon for a sip of Southern hospitality by way of Texas, and a samplin' of some old-fashioned country vibes.…

Don't be caught empty-handed (or empty-hearted) this Valentine's Day, coming up Friday, Feb. 14.…

Weeks after being raped at a wedding — an experience already wrapped in feelings of self-blame and fear — the 18-year-old Eastern Washington University student realized something else was wrong.…

The '20s issue The '20s are back, baby.…

Tool's music is not only not for everyone, it's such a challenging polyglot of oft-derided musical styles that it risks not being for anyone. And yet, the quartet's blend of prog-rock, art-rock, metal and performance art has become a genre unto itself over the course of 30 years, and it's a genre that has proved remarkably commercial.…

The new documentary Circus of Books is predicated on an intriguing and admittedly amusing bit of cognitive dissonance: One of Los Angeles' premier adult emporiums was, for decades, operated by a buttoned-up, middle-aged Jewish couple, who kept the true nature of their jobs hidden from even their closest acquaintances.…

At around 5:30 pm on Thursday, there were two camps of people set up in Coeur d'Alene Park in Browne's Addition.…

The invention discloses quinoxaline derivatives or salts thereof having PDE9-inhibiting activity and being useful as treating agent of dysuria and the like, which are represented by the formula (I) in the formula, R1 and R2 each independently stands for hydrogen, halogen, alkyl, alkoxy, acyl, amino and the like,R3 stands for alkyl, aryl, saturated carbocyclic group, saturated heterocyclic group, acyl and the like,R4 stands for hydrogen, hydroxy, alkyl or amino,R5 and R8 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkoxy, cyano or nitro,R6 and R7 each independently stands for hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, cyano, amino, carbocyclic group, heterocyclic group, COR9 or SO2R9,R9 stands for hydrogen, hydroxy, alkyl, amino, pyrrolidin-1-yl, piperidin-1-yl, pyperazin-1-yl or the like,X stands for S or O, andA1, A2 and A3 each independently stands for N or C.

Provided are a three-phase coaxial superconducting power cable and a structure thereof. A certain space is formed between adjacent superconducting wires of a superconducting layer (disposed at an outer portion) having more superconducting wires among a plurality of superconducting layers, and another wire is disposed in the space, or the superconducting wires of the respective superconducting layers are disposed to have different critical currents. Accordingly, a waste of superconducting wires is prevented, and the optimized three-phase coaxial superconducting power cable is provided.

Substituted phenylcarbamoyl alkylamino arenes; substituted phenylthiocarbamyl alkylamino arenes; substituted phenylcarbamoyl alkylamino heteroarenes; substituted phenylthiocarbamyl alkylamino heteroarenes; N-substituted aryl, N'-substituted aryl urea compounds; N-substituted aryl, N'-substituted heteroaryl urea compounds; N-substituted aryl, N'-substituted aryl thiourea compounds and N-substituted aryl, N'-substituted heteroaryl thiourea compounds are provided and may find use as androgen receptor modulators. The compounds may find particular use in treating prostate cancer, including castration-resistant prostate cancer and/or hormone-sensitive prostate cancer.

Disclosed are methods of purifying (20R) and (20S) analogs of 2-methylene-19-nor-22-dimethyl-1α,25-dihydroxyvitamin D3 to obtain the (20R) and (20S) analogs in crystalline form. The method includes the steps of preparing a solvent of either diethyl ether or a mixture of 2-propanol and hexane, dissolving a product containing the (20R) and (20S) analog to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective because that they mostly come from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

Disclosed are methods of purifying the compound (20R)-2-methylene-19-nor-24-difluoro-1α,25-dihydroxyvitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving a product containing the compound in a solvent comprising hexane and 2-propanol, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

This invention discloses N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs, and specifically N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-1α-hydroxyvitamin D3 and pharmaceutical uses therefor. This compound exhibits relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent especially for the treatment or prevention of leukemia, colon cancer, breast cancer, skin cancer or prostate cancer.

This invention discloses 3-desoxy-2-methylene-19-nor-vitamin D analogs, and specifically (20S)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 and (20R)-3-desoxy-2-methylene-1α,25-dihydroxy-19-nor-vitamin D3 as well as pharmaceutical uses therefor. These compounds exhibit relatively high binding activity and pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to monocytes thus evidencing use as anti-cancer agents especially for the treatment or prevention of osteosarcoma, leukemia, colon cancer, breast cancer, skin cancer or prostate cancer. These compounds also exhibit relatively high calcemic activity evidencing use in the treatment of bone diseases.

Disclosed are methods of purifying the compound (20R)-19-nor-24-difluoro-1α,25-dihydroxyvitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving a product containing the compound in a solvent comprising hexane and 2-propanol, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.

The portable, wearable, proximal Alzheimer's disease treatment invention is based upon creating an RF field of particular frequencies and intensities that are applied to the patient's head. To accomplish the aforementioned disease treatment functionality, a system was invented comprising a network of antennas connected to an RF generator via a feedline connector. The invention also provides methods for using measurements to monitor and manage the effectiveness of an ongoing disease treatment regimen, and databases which contain information about measurements, variables, and their relationships to clinical outcome.

The invention relates to the soybean variety designated 01046169. Provided by the invention are the seeds, plants and derivatives of the soybean variety 01046169. Also provided by the invention are tissue cultures of the soybean variety 01046169 and the plants regenerated therefrom. Still further provided by the invention are methods for producing soybean plants by crossing the soybean variety 01046169 with itself or another soybean variety and plants produced by such methods.

The present invention provides an inbred corn line designated KDL6289, methods for producing a corn plant by crossing plants of the inbred line KDL6289 with plants of another corn plant. The invention further encompasses all parts of inbred corn line KDL6289, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line KDL6289, and plants produced according to these methods.

In an embodiment, the invention relates to the seeds, plants, and plant parts of canola variety SCV435009 and to methods for producing a canola plant produced by crossing canola variety SCV435009 with itself or with another canola variety. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola varieties or breeding lines and plant parts derived from canola variety SCV435009, to methods for producing other canola varieties, lines or plant parts derived from canola variety SCV435009 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the variety SCV435009 with another canola variety.

The present invention provides an inbred corn line designated FX8609, methods for producing a corn plant by crossing plants of the inbred line FX8609 with plants of another corn plant. The invention further encompasses all parts of inbred corn line FX8609, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line FX8609, and plants produced according to these methods.

The present invention provides an inbred corn line designated MFX7589, methods for producing a corn plant by crossing plants of the inbred line MFX7589 with plants of another corn plant. The invention further encompasses all parts of inbred corn line MFX7589, including culturable cells. Additionally provided herein are methods for introducing transgenes into inbred corn line MFX7589, and plants produced according to these methods.

The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates to a method of inhibiting a function of CCR9, and to the use compounds represented by Structural Formula I in research, therapeutic, prophylactic and diagnostic methods.

The present invention provides transgenic soybean event MON87769, and cells, seeds, and plants comprising DNA diagnostic for the soybean event. The invention also provides compositions comprising nucleotide sequences that are diagnostic for said soybean event in a sample, methods for detecting the presence of said soybean event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said soybean event in a sample, growing the seeds of such soybean event into soybean plants, and breeding to produce soybean plants comprising DNA diagnostic for the soybean event.

Disclosed herein are compounds that inhibit Hsp90 interactions with IAP proteins, such as Survivin, XIAP, cIAP1, or cIAP2, and methods for identifying and using such compounds.

The present disclosure relates to a Co-029 inhibitor for inhibiting the migration of cancer cells which express Co-029. The disclosure relates to a Co-029 inhibitor for the treatment of cancer and/or the prevention of cancer metastasis and pharmaceutical compositions comprising said inhibitor and provides Co-029 antibodies. The disclosure provides a method for predicting the response of a patient afflicted with or susceptible to be afflicted with cancer to a medical treatment with a Co-029 inhibitor, a method for diagnosing a cancer in a patient and a method for predicting the survival in a cancer patient.

Methods for creating customized children's storybooks with fingerprint art using fingerprint-ready templates stored in association with a software application on a desktop computer, a tablet computer, or a smart phone. The methods include the use of preconfigured templates and prompted discussions that elicit responses from the child to create text for the storybook. The text may be generated by speech recognition software processing digital audio recordings of the child's responses. A digital image of the child's fingerprint is acquired and the fingerprint image and/or the storybook scenes are scaled to fit each other. Fingerprint-ready image templates are used to facilitate the creation of fingerprint art. A completed page image is formed by digitally inserting a fingerprint into the fingerprint-shaped area, and if desired, coloring the image or drawing a scene around the image. When the scenes are completed the software application compiles the book pages and prints the same.

The present invention relates to an anti-human α9 integrin antibody. More particularly, the present invention relates to: a monoclonal antibody, a chimeric antibody, a humanized antibody and a human antibody that specifically recognize human α9 integrin; a hybridoma cell that produces the monoclonal antibody; a method for producing the monoclonal antibody; a method for producing the hybridoma cell; a therapeutic agent comprising the anti-human α9 integrin antibody; a diagnostic agent comprising the human α9 integrin antibody; and a method for screening for a compound that inhibits the activity of human α9 integrin.

A novel maize variety designated PH1M9D and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1M9D with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1M9D through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1M9D or a locus conversion of PH1M9D with another maize variety.

A foldable children's tricycle comprises a tricycle front, a link device and a positioning assembly. The tricycle can be folded by using the link device, which can save space and reduce transportation cost. In addition, an inserting rod of the positioning assembly can be engaged in first or second positioning grooves of the link device, so the tricycle can be fixed when expanding or folding, thus improving the structural strength of the tricycle.

A children's tray with a placement indicator includes a tray and a groove/spot formed in the tray to indicate where an eating item (including food, utensils, or dishware) is to be placed. The tray can be mounted, removably or fixedly, to a variety of child support structures, including high chairs, booster seats and bouncers and includes a wall around the periphery intended to prevent items from falling off of the tray. The groove/spot formed in the tray may be formed from of a material having a higher coefficient of friction than the material used to form the tray. The groove/spot formed in the tray may be formed from of a material having a different color than the material used to form the tray.