y A multifunctional “three-in-one” fluorescent theranostic system for hepatic ischemia–reperfusion injury By pubs.rsc.org Published On :: Chem. Sci., 2024, Advance ArticleDOI: 10.1039/D4SC04962D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Jihong Liu, Dongni Yin, Wen Zhang, Xin Wang, Tony D. James, Ping Li, Bo TangA single-component multifunctional fluorescent theranostic system (MB-Gly) for use during hepatic ischemia-reperfusion injury (HIRI) has been developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Phase transition induced hydrogen activation for enhanced furfural reductive amination over CoCu bimetallic catalyst By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05885B, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yilin Wei, Zixu Ma, Beibei Liu, Jialin Yang, Dan Wu, Yongsheng Zhang, Yuexing Zhang, Charles Chunbao Xu, Renfeng NieThe synthesis of primary amines from renewable biomass and its derivatives through reductive amination has garnered significant attention. How to construct efficient non-noble-metal catalysts that enable low-temperature catalysis still remains...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y TcESTIME: predicting high-temperature hydrogen-based superconductors By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC04465G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Trinidad Novoa, Matías E. di Mauro, Diego Inostroza, Kaoutar El Haloui, Nicolas Sisourat, Yvon Maday, Julia Contreras-GarcíaSuperconductivity can be considered among the most exciting discoveries in material science of the XXth century. However, the hard conditions for the synthesis and the difficult characterization, make the statement...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Gaining the Molecular Design Principles for Efficient Diarylethene Photoacid and Photohydride Generators Based on Photochemical Reaction Mechanism By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC06202G, Edge Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Yifan Su, Dexin Zheng, Lingfeng Ge, Le Yu, David Lee Phillips, Jiani Ma, Yu FangAbstract: Photoacid generators (PAGs) and photohydride generators (PHGs) are specific photolabile protecting groups that release acid and hydride, respectively. Over the past decade, great efforts have been devoted to developing...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Synthesis of highly condensed phospholes by Lewis acid-assisted dehydrogenative Mallory reaction under visible light irradiation By pubs.rsc.org Published On :: Chem. Sci., 2024, Accepted ManuscriptDOI: 10.1039/D4SC05657D, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Ikki Kamiyoshi, Yuki Kojima, Shibo Xu, Kosuke Yasui, Yuji Nishii, Koji HiranoA photo-promoted oxidative cyclization, that is, Mallory reaction of 2,3-diarylbenzophopholes has been developed. With an assistance of Bi(OTf)3 Lewis acid, the reaction proceeds smoothly under visible light irradiation even without...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Goalpara Sainik school gave countless cadets to country: Assam Guv By www.newkerala.com Published On :: Wed, 13 Nov 2024 16:00:02 +0530 Full Article
y 'PM Modi's govt gives highest priority to over 35 mn Indian diaspora', says EAM Jaishankar on website launch for Pravasi Bharatiya Divas By www.newkerala.com Published On :: Wed, 13 Nov 2024 16:04:01 +0530 Full Article
y $19 mn Loss & Damage funding pledged by Sweden at COP29, bringing total pledged funding to $720 mn By www.newkerala.com Published On :: Wed, 13 Nov 2024 16:12:02 +0530 Full Article
y Providing better healthcare biggest priority: PM Modi ahead of Darbhanga AIIMS inauguration By www.newkerala.com Published On :: Wed, 13 Nov 2024 16:38:02 +0530 Full Article
y Chandigarh's air quality continues to be worse than Punjab, Haryana By www.newkerala.com Published On :: Wed, 13 Nov 2024 18:22:02 +0530 Full Article
y India's CO2 emissions account 8pc of global total, to rise by 4.6pc in 2024: Report By www.newkerala.com Published On :: Wed, 13 Nov 2024 18:34:02 +0530 Full Article
y Assam: Army celebrates 'National Education Day' with students in Tinsukia By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:08:01 +0530 Full Article
y UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:10:02 +0530 Full Article
y Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:14:02 +0530 Full Article
y There will be census in country but not based on caste: Union Minister Shobha Karandlaje By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:18:02 +0530 Full Article
y Rajnath Singh stresses on adaptive defence to cope with Age of Grey Zone, hybrid warfare By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:20:02 +0530 Full Article
y Indian Coast Guard evacuates critically ill fisherman off Diu coast By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:24:02 +0530 Full Article
y Akashteer: Transforming India's air defence with cutting-edge technology By www.newkerala.com Published On :: Wed, 13 Nov 2024 19:26:02 +0530 Full Article
y All cases related to loan fraud at Perumbavoor Urban Cooperative Society to be handed over to Crime Branch By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:46:46 +0530 Police say 29 cases have been registered. Probe by district joint registrar of Cooperative department finds 26 persons, mostly members of previous director boards, accountable for irregularities to the tune of ₹33.33 crore Full Article Kerala
y HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:14:08 +0530 Full Article Kochi
y French lower house rejects massively amended 2025 budget By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:53:03 +0530 Prime Minister Michel Barnier's minority government now has a largely free hand in submitting a cleaned-up text to the Senate upper house Full Article World
y ‘Anti-war’ comedy play riles Bulgarian nationalists By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:50:04 +0530 Last week’s premiere of Arms and the Man by renowned Irish-born playwright George Bernard Shaw sparked raucous protests by nationalist groups Full Article World
y Cold War-era H-6 bomber enhances China’s ability to strike U.S. bases By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:14:26 +0530 The H-6 long-range bomber was used in China’s October war games around Taiwan; it flew close to the U.S. mainland for first time in June Full Article World
y Sri Lanka to hold key parliamentary vote on November 14 By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:35:59 +0530 President Anura Kumara Dissanayake’s ruling alliance is looking to secure a majority in Parliament Full Article World
y Senior Russian naval officer killed in car bombing claimed by Kyiv By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:48 +0530 Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify Full Article World
y Indonesia and Australia hold joint military drills after signing a new defense agreement By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:32:15 +0530 The Indonesian and Australian militaries are holding joint combat drills off Indonesia’s main island of Java with about 2,000 troops training in air, maritime, amphibious and land operations Full Article World
y Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3639-3651DOI: 10.1039/D4MD00183D, Review ArticleAbdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke HisamatsuTRAIL induced apoptosis signalling by death receptors (DR4/DR5).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
y Supreme Court stays order for CBI probe into sexual assault of minor in Chennai By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:07:47 +0530 Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre Full Article Tamil Nadu
y IIT Madras to conduct two-day summit on extended reality By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:19:23 +0530 The aim is to develop academic partnership programmes to boost research in XR or extended reality Full Article Chennai
y T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:15:58 +0530 It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students Full Article Tamil Nadu
y IIT-M students develop robot for O.P. Jindal university’s Constitution Museum By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:27 +0530 It is trained to respond to questions from visitors in Hindi and English, IIT-M professor says Full Article Tamil Nadu
y Southern Railway refuses to share inquiry report of Perumon train tragedy By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:15:33 +0530 105 people had died in after several coaches of the Island Express fell into the Ashtamudi Lake in 1988 Full Article Tamil Nadu
y Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:14:04 +0530 Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m. Full Article Delhi
y Delhi High Court upholds ban on two-wheelers on Expressways By www.thehindu.com Published On :: Wed, 13 Nov 2024 16:18:26 +0530 Two-wheelers, three-wheelers, and other slow-moving vehicles, such as tractors, are prohibited as per the Gazette Notifications dated June 14, 2018, and January 15, 2021 Full Article Delhi
