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Pyridine tetrafluoro-λ6-sulfanyl chlorides: spontaneous addition to alkynes and alkenes in the presence or absence of photo-irradiation

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00339E, Research Article
Kiyoteru Niina, Kazuhiro Tanagawa, Yuji Sumii, Norimichi Saito, Norio Shibata
A radical addition reaction of Py-SF4Cl to alkynes and alkenes provide pyridine-SF4-alkenes and pyridine-SF4-alkanes under blue LED light irradiation or absence of light irradiation in CPME or without solvent.
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Discovery of new polycyclic polyprenylated acylphloroglucinols with diverse architectures as potent cyclooxygenase-2 inhibitors

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00259C, Research Article
Shuangshuang Xie, Changxing Qi, Yulin Duan, Qianqian Xu, Yaping Liu, Yingying Huang, Xu Yin, Weiguang Sun, Yuan Zhou, Yonghui Zhang
Cyclooxygenase-2 (COX-2) is a significant therapeutic target of chronic inflammatory diseases.
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Direct organocatalytic asymmetric Michael reaction of fluorine hemiaminal-type nucleophile to 4-nitro-5-styrylisoxazoles

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00348D, Research Article
Luyao Li, Bo Zhu, Huihui Fan, Zhiyong Jiang, Junbiao Chang
Herein, we report a chiral bifunctional thiourea catalyzed asymmetric Michael addition reaction between 2-(trifluoromethyl)oxazol-5(2H)-one as a direct C-2-position nucleophile to 4-nitro-5-styrylisoxazoles for the first time.
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Visible-light mediated oxidative ring expansion of anellated cyclopropanes to fused endoperoxides with antimalarial activity

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00168F, Research Article
Simon Budde, Felix Goerdeler, Johannes Floß, Peter Kreitmeier, Elliot F. Hicks, Oren Moscovitz, Peter H. Seeberger, Huw M. L. Davies, Oliver Reiser
Hetero- and carbocyclic anellated cyclopropanes were converted in one step by a visible light induced photooxidation to their corresponding polycyclic endoperoxides, which show promising antimalarial activity.
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Roquefornine A, a sesterterpenoid with a 5/6/5/5/6-fused ring system from the fungus Penicillium roqueforti YJ-14

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00301H, Research Article
Jia-Peng Wang, Yan Shu, Jun-Tao Hu, Rui Liu, Xue-Yun Cai, Cheng-Tong Sun, Dong Gan, Di-Jiao Zhou, Rui-Feng Mei, Hao Ding, Xiao-Ran Zhang, Le Cai, Zhong-Tao Ding
Roquefornine A, a sesterterpenoid with an unprecedented 5/6/5/5/6-membered pentacyclic system, was characterized from Penicillium roqueforti YJ-14. Its structure was determined by extensive spectroscopic analyses, [Rh2(OCOCF3)4]-induced CD data and DP4+ calculations....
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Transition metal-catalyzed coupling of heterocyclic alkenes via C-H activation: Recent trends and applications

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00279H, Review Article
Sundaravel Vivek Kumar, Sonbidya Banerjee, Tharmalingam Punniyamurthy
Heterocyclic alkenes represent an important class of reactive feedstock and valuable synthons for the synthesis of biologically important heterocyclic scaffolds. Although functionalized heterocyclic alkenes and their derivatives can be accessed...
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Access to cyano-substituted pyrazolines through copper-catalyzed cascade cyanation/cyclization of unactivated olefins

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00282H, Research Article
Fei Meng, Qin Fang, Weidong Yuan, Ning Xu, Shujun Cao, Jianlin Chun, Jie Li, Honglin Zhang, Yingguang Zhu
A mild copper-catalyzed cascade cyanation/cyclization of hydrazone-tethered unactivated olefins was developed for the efficient and practical synthesis of cyano-containing pyrazolines.
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Turn-on fluorescence sensors based on dynamic intramolecular N→B-coordination

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00267D, Research Article
Raphael Koch, Yu Sun, Andreas Orthaber, Antonio J. Pierik, Frank Pammer
A series of ten aryl-triazole-functionalized boranes bearing BMes2-groups and capable of forming intramolecular five-membered N→B-coordinated heterocycles, has been prepared by 1,3-dipolar cycloaddition.
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Organocatalytic 1,5-trifluoromethylthio-sulfonylation of vinylcyclopropane mediated by visible light in the water phase

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00343C, Research Article
Junkai Liu, Hong Yao, Xinnan Li, Hongyu Wu, Aijun Lin, Hequan Yao, Jinyi Xu, Shengtao Xu
1,2-Difunctionalization has developed into a robust tool for the preparation of complex organic molecules, and remote difunctionalization has also aroused widespread interest to achieve pluripotency of difunctionalization.
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Preparation of a mechanically interlocked polymer from a linear supramolecular polymer

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00315H, Research Article
Zibin Zhang, Kechang Sun, Leqiong Jin, Chunsong Xie, Shijun Li
We transformed a linear supramolecular polymer into a mechanically interlocked polymer by photoisomerization.
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Hyperforones A–C, benzoyl-migrated [5.3.1]-type polycyclic polyprenylated acylphloroglucinols from Hypericum forrestii

Org. Chem. Front., 2020, 7,1070-1076
DOI: 10.1039/D0QO00152J, Research Article
Wei-Jia Lu, Wen-Jun Xu, Yan-Qiu Zhang, Yi-Ran Li, Xin Zhou, Qi-Ji Li, Hao Zhang, Jun Luo, Ling-Yi Kong
Unprecedented benzoyl-migrated polycyclic polyprenylated acylphloroglucinols with a unique C-1 H-substituted bicyclo[5.3.1]hendecane framework, hyperforones A–C (1–3), were isolated from Hypericum forrestii.
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Differential formation of nitrogen-centered radicals leading to unprecedented, regioselective bromination of N,N'-(1,2-phenylene)bisamides and 2-amidophenols

Org. Chem. Front., 2020, 7,1095-1106
DOI: 10.1039/C9QO01508F, Research Article
Damoder Reddy Motati, Dilipkumar Uredi, Amarender Goud Burra, J. Phillip Bowen, Frank R. Fronczek, Clint R. Smith, E. Blake Watkins
A highly efficient, site-selective, visible light-accelerated, remote C–H halogenation of unsymmetrical aromatic bisamides/amidoesters has been developed.
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Topomeric aza/thia cryptands: synthesis and theoretical aspects of in/out isomerism using n-alkyl bridging

Org. Chem. Front., 2020, 7,1164-1176
DOI: 10.1039/D0QO00123F, Research Article
Ian S. Taschner, Tia L. Walker, Sharath Chandra M., Briana R. Schrage, Christopher J. Ziegler, Xinfeng Gao, Steven E. Wheeler
A series of heterobicyclic aza/thia-lactams and cryptands incorporating changes in n-alkyl bridging length have been synthesized, characterized, chelated to heavy metals and computationally assessed.
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Synthesis and biological evaluation of suffrutines A, B and their N-fused analogues

Org. Chem. Front., 2020, 7,1122-1131
DOI: 10.1039/D0QO00050G, Research Article
Zefeng Zhu, Chun Chen, Jingxing Jiang, Qianzhong Zhang, Zhibo Du, Shuxian Wei, Xianheng Song, Jie Tang, Jinping Lei, Zhuofeng Ke, Yong Zou
The synthesis, structure confirmation, stability and isomerization features of suffrutines A, B and their N-fused analogues were reported. Biological tests showed that the introduction of nitrogen atom might be beneficial to the anticancer activity.
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Insights into N-heterocyclic carbene and Lewis acid cooperatively catalyzed oxidative [3 + 3] annulation reactions of α,β-unsaturated aldehyde with 1,3-dicarbonyl compounds

Org. Chem. Front., 2020, 7,1113-1121
DOI: 10.1039/D0QO00091D, Research Article
Xinghua Wang, Yang Wang, Jinshuai Song, Donghui Wei
N-Heterocyclic carbene and Lewis acid cooperatively catalyzed oxidative [3 + 3] annulation reactions of 1,3-dicarbonyl compounds have been systematically studied in theory.
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Toward C2-nitrogenated chromones by copper-catalyzed β-C(sp2)–H N-heteroarylation of enaminones

Org. Chem. Front., 2020, 7,1107-1112
DOI: 10.1039/D0QO00065E, Research Article
Tian Luo, Jie-Ping Wan, Yunyun Liu
The synthesis of C2-nitrogenated chromones has been performed via reactions of enaminones and nitrogen nucleophiles based on an unconventional β-C–H bond functionalization and a featured chromone annulation of enaminones.
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Direct synthesis of annulated indoles through palladium-catalyzed double alkylations

Org. Chem. Front., 2020, 7,1149-1157
DOI: 10.1039/D0QO00135J, Research Article
Yadong Gao, Jianhua Li, Songlin Bai, Daoquan Tu, Chao Yang, Zhiwen Ye, Bingcheng Hu, Xiangbing Qi, Chao Jiang
A facile, one-step synthesis of annulated indoles from (N–H) indoles and dibromoalkanes was developed through a palladium-catalyzed double alkylation process.
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The origin of regioselectivity in Cu-catalyzed hydrocarbonylative coupling of alkynes with alkyl halides

Org. Chem. Front., 2020, 7,1137-1148
DOI: 10.1039/D0QO00214C, Research Article
Shengnan Liu, Jianbiao Liu, Qiong Wang, Jin Wang, Fang Huang, Wenjuan Wang, Chuanzhi Sun, Dezhan Chen
Steric interactions mediate a switch between a ketone and allylic alcohol in Cu-catalyzed hydrocarbonylative coupling of alkynes with alkyl halides.
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Rh(III)-Catalyzed switchable C–H functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes

Org. Chem. Front., 2020, 7,1158-1163
DOI: 10.1039/D0QO00248H, Research Article
Shaonan Wu, Zhuo Wang, Dianxue Ma, Chen Chen, Bolin Zhu
We reported a Rh(III)-catalyzed switchable C–H functionalization of 2-(1H-pyrazol-1-yl)pyridine with internal alkynes, which provided diversiform functionalized N,N-bidentate chelating compounds.
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Anthranils: versatile building blocks in the construction of C–N bonds and N-heterocycles

Org. Chem. Front., 2020, 7,1177-1196
DOI: 10.1039/D0QO00163E, Review Article
Yang Gao, Jianhong Nie, Yanping Huo, Xiao-Qiang Hu
This review article provides an overview of the recent progress in the transformations of anthranils, which have emerged as versatile building blocks in the assembly of various C–N bonds and medicinally active heterocyclic systems.
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Recent developments in palladium-catalyzed C–S bond formation

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00377H, Research Article
Jianxiao Li, Shaorong Yang, Wanqing Wu, Huanfeng Jiang
This review summarized the recent developments in palladium-catalyzed C–S bond formation involving sulfenylation and sulfonylation reactions.
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An Aspidosperma-type alkaloid dimer from Tabernaemontana bovina as a candidate for the inhibition of microglial activation

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00296H, Research Article
Yang Yu, Si-Meng Zhao, Mei-Fen Bao, Xiang-Hai Cai
As a representative of twelve undescribed Aspidosperma-type alkaloid dimers, tabernaemontine F (6) inhibited microglial activation by blocking P38 MAPK activation, revealing a potential candidate for chronic neurodegenerative diseases.
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Tricarabrols A–C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00093K, Research Article
Jie Yuan, Xuelan Wen, Chang-Qiang Ke, Tian Zhang, Ligen Lin, Sheng Yao, Jason D. Goodpaster, Chunping Tang, Yang Ye
Three anti-inflammatory trimeric compounds constructed from carabrol-type sesquiterpenoids through a methylene-tethered linkage were characterized from Carpesium faberi.
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Chiral strong Brønsted acid-catalyzed enantioselective addition reaction of simple olefins with ethyl glyoxylate

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00448K, Research Article
Jun Kikuchi, Yuki Aizawa, Masahiro Terada
An enantioselective intermolecular addition reaction of 1,1,2-trisubstituted and 1,2- disubstituted simple olefins with ethyl glyoxylate was developed using F10BINOL-derived N-sulfonyl phosphoramide as a chiral strong Brønsted acid catalyst.
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An exocyclic π-system extension of the phenanthriporphyrin framework: towards azaaceneporphyrinoids

Org. Chem. Front., 2020, Advance Article
DOI: 10.1039/D0QO00436G, Research Article
Bartosz Szyszko, Damian Dróżdż, Aleksandra Sarwa, Sebastian G. Mucha, Agata Białońska, Michał J. Białek, Katarzyna Matczyszyn, Lechosław Latos-Grażyński
An exocyclic π-extension of phenanthriporphyrin reduces the macrocyclic antiaromaticity of the formed expanded carbaporphyrinoids.
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Phosphine/Palladium Cooperative Catalysis: Enantioselective [5+4] Annulations of ortho-Quinone Methides and Vinylethylene Carbonates

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00128G, Research Article
Chao Xia, Dong-Chao Wang, Gui-Rong Qu, Hai-Ming Guo
Highly enantioselective [5+4] annulations of ortho-quinone methides with vinylethylene carbonates were enabled by phosphine/palladium asymmetric cooperative catalysis for the first time. Efficient synthesis of various nine-membered benzo-heterocycles was achieved in...
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Mechanism and Origins of Stereo- and Enantioselectivities of Palladium-Catalyzed Hydroamination of Racemic Internal Allenes via Dynamic Kinetic Resolution: A Computational Study

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00174K, Research Article
Zhenzhen Wu, Mei Zhang, Yu Shi, Genping Huang
Density functional theory calculations have been performed to investigate the Pd-catalyzed hydroamination of racemic internal allenes with pyrazoles. The computations show that the originally proposed reaction mechanisms initiated by the...
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Catalyst-Controlled Formal [4+1] Annulation of N-Vinyl Fluorenone Nitrones and Allenoates to Prepare Spirofluorenylpyrrolines

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00224K, Research Article
Cui Wei, Jin-Qi Zhang, Jia-Jie Zhang, Cui Liang, Dong-Liang Mo
We report a readily commercial Gimeracil-catalyzed formal [4+1] annulation approach for the synthesis of spirofluorenylpyrrolines in good yields with high diastereoselectivity from easily available N-vinyl fluorenone nitrones and allenoates. The...
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A Vinylogous Michael Reaction of 2-Furanones Dimers to α, β-Unsaturated Nitroolefins for Constructing Chiral γ, γ-Disubstituted Butenolides

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00376J, Research Article
Zhushuang Bai, Cairong Zhang, Yongyi Chen, Aiqin Liu, Xinyu Wang, Chuna Yan, Xuechao Liu, Xiaoru Zhang, Ying Li, Ye Yuan, Zemei Ge, Jingxiang Pang, Yongshuai Chai, Xin Wang, Runtao Li
An efficient bifunctional thiourea catalyzed asymmetric vinylogous Michael addition of 2-furanones dimers to α, β-unsaturated nitroolefins has been developed to give the functional chiral γ,γ-disubstituted butenolides in good yields (up...
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Rhodium(III)-catalyzed synthesis of 3-trifluoromethylindanones from N-Methoxybenzamides via C-H activation and Claisen/Retro-Claisen reaction

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00330A, Research Article
Satyasheel Sharma, Bharatkumar Chaudhary, Neeraj Kulkarni
The Rhodium(III)-catalyzed reaction of N-methoxybenzamides as a directing group with β-trifluoromethyl-α,β-unsaturated ketones is reported. The reaction involved sp2 C−H activation, followed by Claisen condensation involving C-N bond cleavage to form...
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Targeted Isolation of Two Disesquiterpenoids Macrocephadiolides A and B from Ainsliaea macrocephala using Molecular Networking-based Dereplication Strategy

Org. Chem. Front., 2020, Accepted Manuscript
DOI: 10.1039/D0QO00030B, Research Article
Yong-Mei Ren, Shuaizhen Zhou, Tian Zhang, Meijia Qian, Rui Zhang, Sheng Yao, Hong Zhu, Chunping Tang, Ligen Lin, Yang Ye
A molecular networking-based dereplication strategy was applied to the phytochemical investigation of Ainsliaea macrocephala, leading to the isolation of two novel disesquiterpenoids macrocephadiolides A (1) and B (2). Their structures,...
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Scientists must write : a guide to better writing for scientists, engineers and students / Robert Barrass

Barrass, Robert




in

Writing scientific papers in English : an ELSE-Ciba Foundation guide for authors / Maeve O'Connor and F.Peter Woodford

O'Connor, Maeve




in

The art of scientific writing : from student reports to professional publications in chemistry and related fields / Hans F. Ebel, Claus Bliefert, William E. Russey

Ebel, Hans Friedrich




in

The basics of technical communicating / B. Edward Cain

Cain, B. Edward, 1942-




in

Communicating in science : writing and speaking / Vernon Booth

Booth, Vernon




in

Writing successfully in science / Maeve O'Connor ; with cartoons by Jenny Gretton

O'Connor, Maeve




in

A guide to scientific writing : manual for students and research workers / David Lindsay

Lindsay, David




in

Handbook of writing for the mathematical sciences / Nicholas J. Higham

Higham, N. J




in

Communicating in science : writing a scientific paper and speaking at scientific meetings / Vernon Booth

Booth, Vernon




in

Writing scientific English : a textbook of English as a foreign language for students of physical and engineering sciences / John Swales

Swales, John




in

A primer of mathematical writing : being a disquisition on having your ideas recorded, typeset, published, read and appreciated / Steven G. Krantz

Krantz, Steven G. (Steven George), 1951-




in

Writing to learn biology / Randy Moore

Moore, Randy




in

Springer handbook of nanotechnology / Bharat Bhushan (ed.)




in

A guide to scientific writing / David Lindsay

Lindsay, D. R




in

Writing and presenting scientific papers / Birgitta Malmfors, Phil Garnsworthy, Michael Grossman

Malmfors, Birgitta




in

Handbook of microscopy for nanotechnology / edited by Nan Yao, Zhong Lin Wang




in

Nanoelectromechanics in engineering and biology / Michael Pycraft Hughes

Hughes, Michael Pycraft, 1970-




in

A student handbook for writing in biology / Karin Knisely

Knisely, Karin




in

Introduction to nanoscale science and technology / edited by Massimiliano Di Ventra, Stephane Evoy. James R. Heflin