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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Advances in antibacterial agents for Mycobacterium fortuitum

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00508B, Review Article
Carlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando Fumagalli
This review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.
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A novel approach for the synthesis of the cyclic lipopeptide globomycin

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00685B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Samantha J. Bann, Stephen A. Cochrane
Lipid swapping: a new approach for the synthesis of globomycin that allows for facile lipid diversification.
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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00722K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice Mangiatordi
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...
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U.S. Presidential polls: Thulasendrapuram residents pray for Kamala Harris ‘victory




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Data crucial for building climate resilience, says ISRO scientist




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Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi




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Three arrested for assaulting doctor in ESI hospital




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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects




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Bids invited for setting up International Dugong Conservation Centre at Manora

The proposed centre, to be set up at an estimate of ₹41 crore, is being established to conserve endangered Dugong species and its habitat in the Palk Bay




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Railways using treated water from its STP for maintaining green spaces

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction




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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa




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NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi




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Guidelines issued for fertilizer distribution in Karaikal for samba, thaladi paddy cultivation




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Art and literary contests lined up for District Central Library’s National Library Week




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Site identified for small-scale handloom park in Karur




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Nagapattinam MP presses for new express trains, railway line extensions




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552: Do You Want to Build a JS Framework? ☃️ CSS Wishlist for 2023

Austin power updates, what do you need if you want to build a new JavaScript framework, and what do we hope CSS brings in 2023?




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556: Andrey Sitnik and Using OKLCH for Color

Andrey Sitnik from Evil Martians talks with us about why OKCLH is the best way forward for color on the web, how to incorporate it into design systems, getting your designers to use OKCLH, and what kind of fallback support is needed.




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579: One Day Builds, Spicy Slugs, and What Next for CSS?

Have you ever been an auctioneer? Sometimes when God closes a shed, he opens a sauna. Dave's working on the one day build theory, how to market with fake data, an update on the Discord, marketing with a spicy slug, what we want to see next in CSS, and thoughts on component libraries.




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580: Chen Hui Jing and the State of CSS Survey for 2023

We're talking the State of CSS Survey, 2023 Edition, with Chen Hui Jing. What was it like helping develop the survey? A bit of follow up on regions, the benefits of being able to tell the browser what you want, language issues in developing and understanding CSS, the struggle for non-majority users, CSS frameworks, and more.




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615: Dave Goes Windows For Real

Dave's got job news to share, as well as insight into the process of what applying for a job in tech is like in 2024. We also talk about styling, scoping, positioning, and floating UI.




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627: Getting Comfortable with the Struggle and Vibe Driven Development

Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future?




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635: Jeff Robbins and Visibox as an Instrument for Video

Jeff Robbins stops by to talk about his software, Visibox, that was used at Frostapalooza for presenting video at the concert, what it's like building an app with Electron, how it's distributed, how files are used and managed, and how he supports hardware devices inside Electron.




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Building practices for the future

Sacred Groves in Auroville is being built using ecologically sensitive construction methods and material.




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For green growth

The State needs to tackle twin challenges of climate change and pressure on natural resources for economic growth.




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It’s good ‘office times’ for Bengaluru

The buoyant office market of Bangalore quite makes up for the lukewarm residential segment, according to findings.




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Options for hot water

Energy consumed in heating water may not appear like a major problem, compared to industries, but thousands of homes each with 2 or 3 heaters may surpass many industries in energy consumption.




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The Big 5 for Chennai

Here are five smart things that Chennai can do to become a cleaner, greener and healthier city.




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Alternatives and affordability

Each housing project has to be site-specific, culturally appropriate and climatically conforming.




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Guidelines for green urbanisation

The Ministry of Urban Development has proposed environmental guidelines for construction projects in urban areas. Nidhi Adlakha reports




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Rooting for sustainability

At the World Bamboo Congress held in Korea this year, Rebecca Reubens spoke about bamboo’s potential for holistic sustainability through design.




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Bikes for last mile connectivity

The Japanese are increasingly shunning cars to help the urban environment get greener.




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Site and foresight

If people could design, build and live happily as per site contexts for thousands of years, why do we need to destroy the rules of nature today?




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A premium for cleanliness

If you’re looking at buying a home, take a pick from one of India’s cleanest cities.




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A ‘green’ transformation

Here is how a city-based couple renovated their home using traditional and sustainable construction




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Ferrari's Leclerc fined for swearing

Stewards at the Brazilian race summoned Leclerc on Friday, acting on a report from the governing FIA's media delegate and after reviewing a written transcript.




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Gunning for a slice of billion-dollar defence contracts 

How a college project birthed a bootstrapped manufacturer of components for the armed forces 




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October decisions on ‘assisted dying’ for terminally ill

India, UK to legislate on allowing patients this choice




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Looking for unicorns among livestock

Got milk: The rising demand for a healthier, diverse product range is driving the growth of tech-enabled dairy start-ups in India




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A doctor-AI collab for detailed, patient consultations

Jivi.ai taps GenAI to optimise available medical resources and widen healthcare access




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Cargo companies upsize for new business

Booming demand for ecommerce delivery spurs freight handlers to open more centres, digitise for efficiency




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How Ratan Tata pushed for evidence-led ayurveda 

Ratan Tata sought to promote research that could validate ayurveda through contemporary science




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‘Our goal is beauty for each,’ says L’Oréal India chief

Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey




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Getting the gig economy to care for its backbone

Why startups in India cannot afford to take a hands-off approach towards the armies of gig workers they have created




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Fem-tech: Niche and fertile for growth

Offering tech-enabled healthcare solutions exclusively for women, the fem-tech segment is clocking steady growth




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L&T eyes CIS region for solar projects

After West Asia, oil-rich countries like Uzbekistan are generating demand for solar energy 




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Bengaluru startup develops new tech for battery recycling, begins production

Li-ion battery recycler Metastable Materials launches commercial ops