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GOP senator: Let high schools decide about opening




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Federal Judge Denies Relief in Challenge to New Mexico School Reopening Rules

In a case that has drawn the involvement of the Trump administration, a federal judge holds that state rules limiting in-person instruction are not infringing on federal constitutional rights.




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Illinois High Court Backs Pension for One-Day Teacher Substitute

A union lobbyist who worked just one day as a substitute teacher is entitled to a pension worth potentially tens of thousands of dollars annually, the Illinois supreme court has ruled.




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In Illinois, New Budget Caps Raises and Limits Pensions for Teachers

The state's budget bill, which Republican Gov. Bruce Rauner signed into law this week, caps annual raises for end-of-career-teachers, lowering the pension they can receive.




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State-District Tensions Swell Over School Pensions

There’s a tussle over the right balance for who should pick up the tab for teacher retirements and how that affects wealthier and less-wealthy districts.




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South Carolina a unanimous No. 1 in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings

South Carolina a unanimous No. in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings.




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No. 4 Texas Women’s Basketball Dominates SEMO in Home Opener

The No. 4 Texas Longhorns kicked off their season with a 119-47 win over Southeast Missouri State (SEMO) on Sunday at Moody Center. This victory marked Texas' 13th consecutive home opener win, establishing a strong start to the 2024-2




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Girls basketball: No. 1 Lady Pirates roll in opener

Nov. 11—Class 3A preseason No. 1 Greensburg opened the season Friday with an 81-23 victory over Jac-Cen-Del. The Lady Pirates opened the scoring with a steal and layup by Mylie Wilkison. After buckets by Clarie Larrison, Mary Harmon, Wilkison and Leah West, the Lady Pirates led 10-0. JCD got on the board with a 3-pointer by Brooklyn Simon. It was all Greensburg from there in the first quarter. ...




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Lady Vols basketball schedule for 2025-26 season will open vs NC State in Greensboro

Tennessee Lady Vols basketball will open the 2025-26 season with a neutral-site matchup against NC State in Greensboro at First Horizon Coliseum




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Blugolds men’s and women’s basketball have home opener, first games in the new Sonnentag Event Center

EAU CLAIRE— This weekend saw the first basketball games for Blugold men’s and women’s basketball during the Market & Johnson Blugold Tip-Off Tournament. The games were the first to be played at the Sonnentag Event Center, a part of the new $122 million multi-purpose facility which opened earlier this year. The event center has a capacity of 3,500 people for sporting events as compared to the ...




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New underground gallery & auditorium to open beneath historic Mitchell Library building

Friday, 27 October 2023
Sydneysiders and visitors will soon experience the State Library on a whole new level.




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Openbook summer out now!

Tuesday 28 November 2023
Fishing for a great summer read?




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Openbook’s autumn edition showcases diverse talents of Australia’s creative community

Wednesday 6 March 2024
Showcasing diverse talents of Australia’s creative community.




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Intracranially Administered Anti-A{beta} Antibodies Reduce {beta}-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial Activation

Donna M. Wilcock
May 1, 2003; 23:3745-3751
Development Plasticity Repair




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Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type

Guo-qiang Bi
Dec 15, 1998; 18:10464-10472
Articles




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Mu-Opioid Receptor (MOR) Dependence of Pain in Chemotherapy-Induced Peripheral Neuropathy

We recently demonstrated that transient attenuation of Toll-like receptor 4 (TLR4) in dorsal root ganglion (DRG) neurons, can both prevent and reverse pain associated with chemotherapy-induced peripheral neuropathy (CIPN), a severe side effect of cancer chemotherapy, for which treatment options are limited. Given the reduced efficacy of opioid analgesics to treat neuropathic, compared with inflammatory pain, the cross talk between nociceptor TLR4 and mu-opioid receptors (MORs), and that MOR and TLR4 agonists induce hyperalgesic priming (priming), which also occurs in CIPN, we determined, using male rats, whether (1) antisense knockdown of nociceptor MOR attenuates CIPN, (2) and attenuates the priming associated with CIPN, and (3) CIPN also produces opioid-induced hyperalgesia (OIH). We found that intrathecal MOR antisense prevents and reverses hyperalgesia induced by oxaliplatin and paclitaxel, two common clinical chemotherapy agents. Oxaliplatin-induced priming was also markedly attenuated by MOR antisense. Additionally, intradermal morphine, at a dose that does not affect nociceptive threshold in controls, exacerbates mechanical hyperalgesia (OIH) in rats with CIPN, suggesting the presence of OIH. This OIH associated with CIPN is inhibited by interventions that reverse Type II priming [the combination of an inhibitor of Src and mitogen-activated protein kinase (MAPK)], an MOR antagonist, as well as a TLR4 antagonist. Our findings support a role of nociceptor MOR in oxaliplatin-induced pain and priming. We propose that priming and OIH are central to the symptom burden in CIPN, contributing to its chronicity and the limited efficacy of opioid analgesics to treat neuropathic pain.




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Erratum: Spencer et al., "Regulation of the Mouse Ventral Tegmental Area by Melanin-Concentrating Hormone"




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Cortically Disparate Visual Features Evoke Content-Independent Load Signals during Storage in Working Memory

It is well established that holding information in working memory (WM) elicits sustained stimulus-specific patterns of neural activity. Nevertheless, here we provide evidence for a distinct class of neural activity that tracks the number of individuated items in working memory, independent of the type of visual features stored. We present two EEG studies of young adults of both sexes that provide robust evidence for a signal tracking the number of individuated representations in working memory, regardless of the specific feature values stored. In Study 1, subjects maintained either colors or orientations across separate blocks in a single session. We found near-perfect generalization of the load signal between these two conditions, despite being able to simultaneously decode which feature had been voluntarily stored. In Study 2, participants attended to two features with very distinct cortical representations: color and motion coherence. We again found evidence for a neural load signal that robustly generalized across these distinct visual features, even though cortically disparate regions process color and motion coherence. Moreover, representational similarity analysis provided converging evidence for a content-independent load signal, while simultaneously showing that unique variance in EEG activity tracked the specific features that were stored. We posit that this load signal reflects a content-independent "pointer" operation that binds objects to the current context while parallel but distinct neural signals represent the features that are stored for each item in memory.




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Pre- and Postsynaptic MEF2C Promotes Experience-Dependent, Input-Specific Development of Cortical Layer 4 to Layer 2/3 Excitatory Synapses and Regulates Activity-Dependent Expression of Synaptic Cell Adhesion Molecules

Experience- and activity-dependent transcription is a candidate mechanism to mediate development and refinement of specific cortical circuits. Here, we demonstrate that the activity-dependent transcription factor myocyte enhancer factor 2C (MEF2C) is required in both presynaptic layer (L) 4 and postsynaptic L2/3 mouse (male and female) somatosensory (S1) cortical neurons for development of this specific synaptic connection. While postsynaptic deletion of Mef2c weakens L4 synaptic inputs, it has no effect on inputs from local L2/3, contralateral S1, or the ipsilateral frontal/motor cortex. Similarly, homozygous or heterozygous deletion of Mef2c in presynaptic L4 neurons weakens L4 to L2/3 excitatory synaptic inputs by decreasing presynaptic release probability. Postsynaptic MEF2C is specifically required during an early postnatal, experience-dependent, period for L4 to L2/3 synapse function, and expression of transcriptionally active MEF2C (MEF2C-VP16) rescues weak L4 to L2/3 synaptic strength in sensory-deprived mice. Together, these results suggest that experience- and/or activity-dependent transcriptional activation of MEF2C promotes development of L4 to L2/3 synapses. Additionally, MEF2C regulates the expression of many pre- and postsynaptic genes in postnatal cortical neurons. Interestingly, MEF2C was necessary for activity-dependent expression of many presynaptic genes, including those that function in transsynaptic adhesion and neurotransmitter release. This work provides mechanistic insight into the experience-dependent development of specific cortical circuits.




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See What Happened When One Museum Asked Artists to Define ‘Home’

The Smithsonian Design Triennial presents 25 commissions that explore the physical and conceptual ideas of shelter and refuge




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Director General opens FAO Council meeting

FAO Director-General Graziano da Silva today opened the 150th session of the FAO Council, highlighting the successful conclusion of the Second International Conference on Nutrition (ICN2), held last month in [...]




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FAO Open Day

As part of the Open House Roma Initiative, FAO is joining over 200 sites around Rome and is opening its doors to the public on 6 and 7 May. This [...]




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FAO Open Day

After the success of the “FAO Open Day” last year, the second FAO OPEN DAY will take place on Saturday 12 and Sunday 13 May 2018, as part of the [...]




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FAO Open Day

Visit FAO on 11 or 12 May to find out about FAO’s mandate and work, and its key role in supporting countries in their efforts to achieve Zero Hunger. This [...]




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Opening Ceremony of the International Year of Millets 2023

The Food and Agriculture Organization of the United Nations (FAO) would like to invite you to the opening ceremony of the International Year of Millets 2023

 




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Ask Smithsonian: Why Do We Have an Appendix?

The appendix may not be as useless as commonly thought.




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What Happens When Galaxies Collide?

In about four billion years from now, the Milky Way and Andromeda galaxies will crash together Visualization: NASA, ESA, and F. Summers, STScI Simulation credit: NASA, ESA, G. Besla, Columbia University, and R. van der Marel, STScI




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This Pendant Is Britain’s Oldest Piece of Iron Age Art

A small pebble with ornate markings is Britain’s earliest piece of Mesolithic art—but what do the markings denote, and was it worn for cosmetic purposes or spiritual ones?




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Ask Smithsonian: What Would Happen if a Solar Flare Hit the Earth?

"Be prepared” might not cover it when it comes to super storms.




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How We See Oppenheimer (redux)

Christopher Nolan's epic new film "Oppenheimer" is no mere biopic… nor is it the first attempt to capture the father of the atomic bomb in fiction. We look at prior dramatizations of this very complicated man—including one wherein J. Robert Oppenheimer played himself!—and examine why they worked or didn't. In this episode: Physicist-turned-photographer Minesh Bacrania shares his experience photographing inside the top-secret labs at Los Alamos National Laboratory, where J. Robert Oppenheimer and other scientists created the first nuclear weapon. Next, with Christopher Nolan’s film Oppenheimer exceeding commercial expectations, Smithsonian magazine writer Andy Kifer discusses the complexities of Oppenheimer's genius and how prior attempts to depict him in film and television and on stage have fared. Read Andy Kifer’s “The Real Story Behind Christopher Nolan’s Oppenheimer” here (https://www.smithsonianmag.com/history/the-real-history-behind-christopher-nolans-oppenheimer-180982529/) . See Minesh Bacrania’s photographs of Los Alamos and read Smithsonian senior editor Jennie Rothenberg Gritz’s text here (https://www.smithsonianmag.com/history/exclusive-behind-scenes-look-los-alamos-lab-where-robert-oppenheimer-created-atomic-bomb-180982336/) or in the July/August 2023 issue of Smithsonian. Original release date: July 27, 2023 There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Genevieve Sponsler, Adriana Rozas Rivera, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Episode artwork by Emily Lankiewicz. Music by APM Music.




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What Happened to Henry VIII's Six Wives?

From tumultuous love affairs to violent betrayals, the six wives of Henry VIII all left marks on the Tudor dynasty – and shaped the course of history. READ MORE about these women here: https://www.smithsonianmag.com/history/the-true-history-behind-six-the-musical-about-henry-viiis-wives-180978781/ --- For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald




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Ask Smithsonian: What Would Happen if a Large Asteroid Hit the Moon?

Think blockbuster movie and you’ve got an idea of how this story ends




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Underwater Archaeology in Pensacola Bay

Researchers from the University of West Florida are slowly uncovering the remains of a 16th-century shipwreck of a Spanish galleon in the shallow, murky waters near Pensacola




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Discovery of the Lake Serpent in Lake Erie

Video by David VanZandt




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The Renwick Gallery Opens




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Ask Smithsonian: What Happens to Your Body in Space Without a Spacesuit?

Obviously it's a bad idea to go out into space without a trusty spacesuit, but what exactly happens?




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How We See Oppenheimer. Plus: Smithsonian’s Inside Look at the Top-Secret Los Alamos Site

Christopher Nolan's epic new film "Oppenheimer" is no mere biopic… nor is it the first attempt to capture the father of the atomic bomb in fiction. We look at prior dramatizations of this very complicated man—including one wherein J. Robert Oppenheimer played himself!—and examine why they worked or didn't. In the episode: Physicist-turned-photographer Minesh Bacrania shares his experience photographing inside the top-secret labs at Los Alamos National Laboratory, where J. Robert Oppenheimer and other scientists created the first nuclear weapon. Next, with Christopher Nolan’s film Oppenheimer exceeding commercial expectations, Smithsonian magazine writer Andy Kifer discusses the complexities of Oppenheimer's genius and how prior attempts to depict him in film and television and on stage have fared. Read Andy Kifer’s “The Real Story Behind Christopher Nolan’s Oppenheimer” here (https://www.smithsonianmag.com/history/the-real-history-behind-christopher-nolans-oppenheimer-180982529/) . See Minesh Bacrania’s photographs of Los Alamos and read Smithsonian senior editor Jennie Rothenberg Gritz’s text here (https://www.smithsonianmag.com/history/exclusive-behind-scenes-look-los-alamos-lab-where-robert-oppenheimer-created-atomic-bomb-180982336/) or in the July/August 2023 issue of Smithsonian. There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Genevieve Sponsler, Adriana Rozas Rivera, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Episode artwork by Emily Lankiewicz. Music by APM Music.




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Ask Smithsonian: What Would Happen if the Yellowstone Volcano Erupted?

Have you ever wondered why Yellowstone is full of hot springs, bubbling mudpots and geysers like Old Faithful? In this one-minute video, Ask Smithsonian host Eric Schulze explains the supervolcano that lies beneath this national park and answers the life-or-death question: Will it erupt in a fiery inferno anytime soon?




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What Happens When the Colorado River Dries Up?

What happens when one of the nation's largest rivers dries up? Photojournalist Pete McBride tells us about the consequences of a prolonged drought in the Colorado River, which provides drinking water and electricity to millions of Americans, and shares his experience walking the river from end to end. What can we learn from the landscape revealed by the historically low water levels, and will they become the new normal? Read “The Breathtaking Glen Canyon Reveals Its Secrets (https://www.smithsonianmag.com/science-nature/glen-canyon-reveals-its-secrets-180980754/) ,” photographs & text by Pete McBride, Smithsonian, October 2022. Learn more about Pete and his work at his site (https://petemcbride.com/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Terence Bernardo, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Episode artwork by Emily Lankiewicz. Music by APM Music.




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The Wild Story of What Happened to Pablo Escobar’s Hungry, Hungry Hippos

Four decades ago, Pablo Escobar brought to his Medellín hideaway four hippopotamuses, the centerpieces of a menagerie that included llamas, cheetahs, lions, tigers, ostriches and other exotic fauna. After Colombian police shot Escobar dead in December 1993, veterinarians removed the animals—except the hippos, which were deemed too dangerous to approach. The hippos fled to the nearby Magdalena River and multiplied.  Today, the descendants of Escobar’s hippos are believed to number nearly 200. Their uncontrolled growth threatens the region’s fragile waterways. Smithsonian contributor Joshua Hammer joins us to recount this strange history and explain why Colombian conservationists have embarked upon an unusual program to sterilize these hippos in the wild via “invasive surgical castration,” a procedure that is, as he has written (https://www.smithsonianmag.com/science-nature/pablo-escobar-abandoned-hippos-wreaking-havoc-colombian-jungle-180984494/) for Smithsonian magazine, “medically complicated, expensive and sometimes dangerous for hippos as well as for the people performing it.” Then, ecologist Rebecca Lewison tells us how her long-term study of hippo populations in Africa offers hints of how these creatures will continue to alter the Colombian ecosystem—and what authorities can do about it. Let us know what you think of our show, and how we can make it better, by completing our There's More to That listener survey here (https://docs.google.com/forms/d/e/1FAIpQLSfS90zjBZ2oGa9JxVa-R5affKcOHaR2-ib1_KZeWm3HDQXJIA/viewform) . Read Josh Hammer's Smithsonian story about Escobar's hippos and their descendants here (https://www.smithsonianmag.com/science-nature/pablo-escobar-abandoned-hippos-wreaking-havoc-colombian-jungle-180984494/) . Learn more about Rebecca Lewison and her work here (https://cmi.sdsu.edu/rebecca-lewison/) . Find prior episodes of our show here (https://www.smithsonianmag.com/podcast/) . There’s More to That is a production of Smithsonian magazine and PRX Productions. From the magazine, our team is Chris Klimek, Debra Rosenberg and Brian Wolly. From PRX, our team is Jessica Miller, Adriana Rosas Rivera, Genevieve Sponsler, Rye Dorsey, and Edwin Ochoa. The Executive Producer of PRX Productions is Jocelyn Gonzales. Fact-checking by Stephanie Abramson. Episode artwork by Emily Lankiewicz  Music by APM Music.




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What Really Happened With the Political Mayhem of the Election of 1800?

Two titans of the era went head-to-head in a heated race for the presidency. The stakes were high. The very future of a young nation hung in the balance. Join us as we explore the revolutionary ideas that shaped this critical moment in American democracy. --- For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald




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Opening Jim Thorpe's Wheaties

Read more about Thorpe: http://j.mp/M9PsXT Smithsonian conservators go to extreme lengths to prepare an iconic box of cereal for display




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What Will Happen to Puerto Maldonado

A local fisherman talks about the uncertain future facing locals when the new bridge connecting Peru and Brazil is completed




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Rare Yellow-Eyed Penguin Wins New Zealand's Bird of the Year Contest

The noisy-but-shy bird, known as the hoiho, has earned the most votes for a second time amid threats to its survival




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Meet Pesto, the Biggest Baby Penguin This Australian Aquarium Has Ever Seen

Most adult king penguins weigh between 31 and 37 pounds. At nine months old, a 51.8-pound Pesto is already looming over his parents




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Asheville's Biltmore Estate Will Reopen for the Holidays After Sustaining Damage From Hurricane Helene

The sprawling estate, which is the largest privately owned home in the country, will open its doors in November after a month-long closure




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New 'Portal' Opens in Philadelphia, Connecting Residents to Cities Around the World With Identical Installations

The looming sculpture features a small camera above an eight-foot-tall screen, which displays live video from Lithuania, Poland and Ireland




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The Nation's Oldest Schoolhouse for Black Children Will Open to the Public Next Year

Work is underway to restore the Bray School, which will be dedicated in a ceremony on Friday. The historic building in Colonial Williamsburg will open its doors in the spring of 2025




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See New Images of Pesto, Australia's Enormous Baby Penguin, in His 'Awkward Phase,' Molting His Downy Feathers

The viral king penguin chick at Sea Life Melbourne Aquarium is beginning to lose his youthful down, a process that will give him his distinctive and waterproof adult plumage




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Surfer Spots an Emperor Penguin on a Beach in Australia, Thousands of Miles From Its Antarctic Home

It's not clear how the juvenile male ended up so far north, but experts suggest he was motivated by his appetite