C-X-C motif chemokine receptor 4 (CXCR4)–directed imaging has gained clinical interest in aiding clinical diagnostics in primary aldosteronism (PA). We retrospectively evaluated the feasibility of CXCR4-directed scintigraphy using the novel CXCR-4 ligand [^99mTc]Tc-pentixatec in patients with PA. Methods: Six patients (mean age ± SD, 49 ± 15 y) underwent CXCR4-directed scintigraphy (including planar imaging and SPECT/CT) 30, 120, and 240 min after injection of 435 ± 50 MBq of [^99mTc]Tc-pentixatec. Adrenal CXCR4 expression was analyzed by calculating lesion-to-contralateral ratios (LCRs). Imaging results were correlated to clinical information. Histopathology and clinical follow-up served as the standard of reference. Results: Three subjects showed lateralization of adrenal tracer accumulation, with a mean maximum lesion-to-contralateral ratio of 1.65 (range, 1.52–1.70), which correlated with morphologic findings on CT. One individual underwent adrenalectomy and presented with complete biochemical and clinical remission at follow-up. Histopathologic workup confirmed unilateral aldosterone-producing adenoma. Conclusion: [^99mTc]Tc-pentixatec scintigraphy with SPECT in patients with PA is feasible and might offer a valuable alternative to CXCR4-directed imaging with [⁶⁸Ga]Ga-pentixafor PET.

Oct. 24, 2024 — The San Diego Supercomputer Center (SDSC), part of the School of Computing, Information and Data Sciences at UC San Diego, has been leading the Open Storage Network (OSN) program for years, and along […]

The post SDSC Leads Expansion of Open Storage Network to More Campus Computing Sites appeared first on HPCwire.

Oct. 16, 2024 — The ISC High Performance Jack Dongarra Early Career Award and Lecture Series is an annual event that honors the remarkable contributions of Professor Jack Dongarra to […]

The post ISC Opens Nominations for 2025 Jack Dongarra Early Career Award in HPC appeared first on HPCwire.

Premier League reference David Coote is suspended indefinitely after videos surfaced that appeared to show him criticizing former Liverpool coach Jurgen Klopp, officials announced Monday.

BEAVERTON, Ore., Oct. 29, 2024 — Ultra Accelerator Link (UALink) Consortium, led by Board Members from AMD, Amazon Web Services (AWS), Astera Labs, Cisco, Google, Hewlett Packard Enterprise (HPE), Intel, Meta […]

The post Ultra Accelerator Link Consortium Launches with Industry Leaders, Opens Membership to Drive AI Connectivity Standards appeared first on HPCwire.

An emperor penguin is being cared for by wildlife experts after becoming the first member of its species to make the 2,200-mile trek from Antarctica to Australia.

June 24, 2024 — Haiqu, a quantum computing startup, announced the release of its new open-source toolkit – Rivet. This new toolkit is made to help developers streamline the execution of […]

The post Haiqu Releases Open-Source Rivet for Quantum Workflow Execution appeared first on HPCwire.

U.S. Defense Secretary Lloyd Austin has pledged to get to the bottom of reports of military personnel experiencing mysterious illnesses while overseas.

The Pentagon on Monday ordered all Department of Defense civilian employees to be fully vaccinated against COVID-19 by no later than Nov. 22.

The movement toward open source AI made progress today when the Open Source Initiative released the first Open Source AI Definition (OSAID). While the OSAID provides one step forward, the […]

The post OSI Open AI Definition Stops Short of Requiring Open Data for LLMs appeared first on HPCwire.

Making the Most of Today’s Cloud-First Approach to Running HPC and AI Workloads With Penguin Scyld Cloud Central™ Bursting to cloud has long been used to complement on-premises HPC capacity […]

The post Penguin Computing Scyld Cloud Central™: A New Cloud-First Approach to HPC and AI Workloads appeared first on HPCwire.

FORT MYERS, Fla., Nov. 7, 2024 — The AlmaLinux OS Foundation, the nonprofit that stewards the free and community-governed open source enterprise Linux distribution, today announced that chair benny Vasquez is […]

The post AlmaLinux OS Foundation Chair to Discuss Embracing Diversity in Open Source at SC24 appeared first on HPCwire.

AI may be a priority at American companies, but the difficulty in managing data and obtaining high quality data to train AI models is becoming a bigger hurdle to achieving […]

The post AI Has a Data Problem, Appen Report Says appeared first on HPCwire.

KAWASAKI, Japan and SANTA CLARA, Calif., Nov. 1, 2024 — Fujitsu and AMD have announced that they have signed a memorandum of understanding (MOU) to form a strategic partnership to […]

The post Fujitsu and AMD to Begin Strategic Partnership to Accelerate Open-source AI initiatives appeared first on HPCwire.

IBM and NASA have developed a new AI foundation model for a wide range of climate and weather applications, with contributions from the Department of Energy’s Oak Ridge National Laboratory. […]

The post IBM and NASA Launch Open-Source AI Model for Advanced Climate and Weather Research appeared first on HPCwire.

Red Hat has announced a signed agreement to acquire Neural Magic, a developer of software and algorithms that accelerate generative AI (gen AI) inference workloads. Red Hat mentions Neural Magic’s […]

The post Red Hat Acquisition Charts Path to Open Accelerated AI appeared first on HPCwire.

Background: Faced with the limits of synthetic antipyretic substances, in particular their involvement in the occurrence of numerous and often serious adverse effects; the challenge is in search of new antipyretics especially from the African traditional pharmacopoeia. The objective of this study was to evaluate the antipyretic activity of an aqueous extract and a formulation of Ceiba pentandra, with a view to designing an herbal antipyretic drug. Methods: Trials of formulation of an antipyretic syrup with leaves extract of Ceiba pentandra were carried out. The antipyretic activity was investigated by the bewer's yeast induced pyrexia. Physicochemical and microbiological stability tests were carried out on the syrup. Results: It was found with the extract an antipyretic activity at doses of 125 mg/kg and 150 mg/kg. The effect was greater for the 125 mg/kg dose with inhibition percentages ranging from 27.58% to 71.25%. This antipyretic activity was early (from 30 minutes) and was preserved during the four hours of the experiment. The syrup dosed at 125 mg/kg gave an activity similar to that of the extract by significantly reducing the hyperthermia in the rats. Regarding the stability tests, the syrup remained stable both physico-chemically and microbiologically throughout the study period (28 days) both when exposed to low temperature (5 °±3 ° C) and at high temperature (40°±2° C). Conclusions: Ceiba pentandra leaves have antipyretic activity and could be used for the development of an herbal antipyretic drug.

A team of U.S. employees at Hachette wrote an open letter to management in protest over a new conservative book imprint created in wake of last week's Donald Trump victory headed by a known far-right publisher.

President-elect Donald Trump on Tuesday night announced his nomination of Fox News host and Army veteran Pete Hegseth to head the Department of Defense.

Billions of dollars are poured into global development every year, but results are lacking, says economist Karthik Muralidharan. Diving into an example with public education, he outlines how smarter resource allocation and evidence-based interventions, like learning software that dynamically responds to students and teaches at the level that's right for them, can accelerate global development worldwide — not by spending more, but by spending smarter.

Montana Superintendent Elsie Arntzen offers practical advice to schools that could open as early as May 7, even as she says "how they open schools and how learning takes place is up to them."

As Montana's governor pursues a plan to gradually reopen the state, the state education department is relying in part on public opinion to decide whether to reopen schools this year.

Distinguished educators are assigned by the state to help low-scoring districts in Pennsylvania. Part of Education Week's special annual report, Leading for Learning.

The lawsuit, filed in 2014, alleges that the state was severely underfunding schools, forcing school districts to lean heavily on property taxes, which especially disadvantages students in property-poor areas.

This Quality Counts 2019 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

This Quality Counts 2020 Highlights Report captures all the data you need to assess your state's performance on key educational outcomes.

This map of Rhode Island shows per-pupil spending by school and just how much spending varies among the schools within individual districts.

The U.S. Supreme Court’s recent ruling was a victory, but it doesn’t take away the hurt of losing my students in a cold February, writes Brett Bigham.

The state requested a waiver from the federal requirement in January. Failure to meet the 95-percent requirement can lead to funding penalties for states.

Ohio Gov. John Kasich is expected to sign a bill into law that would ban suspensions and expulsions for children in prekindergarten through 3rd grade for minor offenses.

Although Native American students make up a small percentage of Wyoming's student population, they are suspended more than their non-minority peers.

Governors in several natural resource-dependent states said recently they will have to continue to cut public education funding because prices for oil and coal have not rebounded.

States’ efforts so far suggest there won’t be enough money to go around for all the learning losses of students with disabilities from COVID-19 school shutdowns.

Maryland's state school board will allow noneducators to be appointed as superintendents of school systems.

School district leaders must make high-stakes decisions with woefully imperfect information.

Relying on newly available data under ESSA, a local advocacy group found several districts that spend more money on wealthy students than poor students, despite the state's intentions.