ge Recent advances from computer-aided drug design to artificial intelligence drug design By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00522H, Review ArticleKeran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei WangCADD and AIDD contribute to the drug discovery.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00579A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-BrocetaA ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00619D, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge Advances in antibacterial agents for Mycobacterium fortuitum By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00508B, Review ArticleCarlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando FumagalliThis review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00623B, Research ArticleOjaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi YaddanapudiA series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00663A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin KrátkýLinking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00558A, Research ArticleLaura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva JúniorThis article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge SIGMAP: an explainable artificial intelligence tool for SIGMA-1 receptor affinity Prediction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00722K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga, Giuseppe Felice MangiatordiDeveloping sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19. In this context, in-silico tools capable of accurately predicting...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ge Four schools and a college in Tiruchi receive hoax bomb threats By www.thehindu.com Published On :: Tue, 05 Nov 2024 14:34:30 +0530 Three schools declared a holiday on Tuesday as a precautionary measure Full Article Tiruchirapalli
ge Changes in train services notified due to demolition of old bridge near Tiruchi junction By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:30:53 +0530 Full Article Tiruchirapalli
ge Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:44:09 +0530 Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago Full Article Tamil Nadu
ge Paddy crop loss compensation pegged at ₹36,500 By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:53:01 +0530 Full Article Tiruchirapalli
ge Govt. urged to extend last date to pay crop insurance premium by farmers By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:45:02 +0530 Full Article Tiruchirapalli
ge Fishermen seek healthcare and cold storage facilities By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:17 +0530 Full Article Tiruchirapalli
ge NTK chief Seeman booked for alleged ‘derogatory remarks’ against Karunanidhi By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:53 +0530 Full Article Tiruchirapalli
ge Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:20:03 +0530 Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand Full Article Tiruchirapalli
ge Advanced baggage handling system introduced in Tiruchi airport By www.thehindu.com Published On :: Sat, 09 Nov 2024 18:01:36 +0530 Full Article Tiruchirapalli
ge Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers By www.thehindu.com Published On :: Mon, 11 Nov 2024 17:08:51 +0530 Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time Full Article Tiruchirapalli
ge 557: ChatGPT, Conferences, Fidgets on the Web, and Modern CSS in Real Life By shoptalkshow.com Published On :: Mon, 20 Mar 2023 07:01:51 +0000 When will AI be able to tell you the risk / reward of cleaning up trees? Are conferences back? Bringing fidgets to the web, internet as an anxiety machine, and Chris is working on talk on modern CSS in real life. Full Article All Episodes AI chatgpt Conferences CSS fidgets
ge 559: Fidget Apps, Coding with AI, Dialog Element Navs, Getting Rid of CSS By shoptalkshow.com Published On :: Mon, 03 Apr 2023 07:14:35 +0000 Is there still any value in specializing in front-of-the-frontend dev? Would you ever use the dialog element for a mobile navigation? Why did CodePen decide to use Go for its GraphQL server? Full Article All Episodes chatgpt dialog Go
ge 563: Getting Pulled by the Algorithm, AI Training Data, and SVG Drawing By shoptalkshow.com Published On :: Mon, 01 May 2023 08:51:30 +0000 There's a special guest on the show who takes aim at the billionaires in web dev, do we know better than the algorithm for news, why is AI training data such a secret, Chris and Dave discover JetBrains, monorepo struggles, and SVG drawing tools. Full Article All Episodes AI JetBrains PHP
ge 565: The Hurdy-Gurdy, OKLCH, Edge Dev Tools, and Ad Blocking By shoptalkshow.com Published On :: Mon, 15 May 2023 08:20:15 +0000 Dave doesn't hate the hurdy-gurdy, but it's creation is an interesting parallel to software development. OKLCH follow up, @media, Edge drops new dev tools, CSS and Astro theming, JavaScript devs discover PHP, how many people block ads, and accessibility and grids. Full Article All Episodes Accessibility edge oklch
ge 571: Searching vs AI, Getting Designers to Play Nice, and Web Components By shoptalkshow.com Published On :: Mon, 26 Jun 2023 09:00:02 +0000 Do you listen at 2x? Do Chris and Dave sound weird at normal speed IRL? How searching compares to using AI, chatbots kind of suck at context, getting a designer to work with developers at an agency, what happened to content visibility, and how to best build a design system using web components. Full Article All Episodes AI chatgpt Web Components
ge 575: CSS Errors, Proxy and Reverse Proxy, and What’s The Edge? By shoptalkshow.com Published On :: Mon, 24 Jul 2023 09:00:16 +0000 Bluesky adds first class support for urls as a username, text-wrap pretty update, sqwunching text update, should CSS spit out errors, anchor functionality, what does the edge mean, eSports and bowling, how to test websites on slower CPUs, and what does proxy or reverse proxy mean? Full Article All Episodes edge proxy text-wrap
ge 576: Blocks, Components, Linting Images, Engines, and “Web Integrity” By shoptalkshow.com Published On :: Tue, 01 Aug 2023 16:59:09 +0000 We're talking how we stay online - or not - on vacation, is create-guten-block the future for us WP developers? Can we get a state of the web component address from the President of web components? Have we seen the last new browser engine? And deciding whether to add features or remove them from your app. Full Article All Episodes Luro Web Components web integrity api
ge 583: Language Models, AI, and Digital Gardens with Maggie Appleton By shoptalkshow.com Published On :: Mon, 18 Sep 2023 08:20:09 +0000 Maggie Appleton talks with us about her work at Elicit, working with large and small language models, how humans vet the responses from AI, the discussion around the Soggoth meme in AI, using Discord as UI, what to do if your boss wants AI in your app, and why does she call her blog a digital garden? Full Article All Episodes AI Design digital garden
ge 584: Community, Partnerships, Images, and Astro with Fred K. Schott By shoptalkshow.com Published On :: Mon, 25 Sep 2023 07:02:00 +0000 Fred K. Schott stops by to talk about building community, open source and sponsorship, building on partnerships in the dev community, WordPress + Astro, view transitions, using Discord for support, and leaking secret Astro Studio details. Full Article All Episodes Astro Community
ge 622: Website Rendering, Updating Software, and Edge Gets Faster By shoptalkshow.com Published On :: Mon, 01 Jul 2024 08:26:04 +0000 We're talking website rendering, server side rendering, Astro's server islands, perf hits for navigation elements, updating software because the docs aren't available for older versions, and a new Microsoft Edge was released. Full Article All Episodes microsoft edge rendering server islands
ge 626: We Were Wrong and Keep Getting in Trouble By shoptalkshow.com Published On :: Mon, 29 Jul 2024 08:22:39 +0000 Chris has some follow up on blog posts and past podcast episodes to respond to including browsers and browser engines, advertising on the web, magazines, Cara, peak AI slop, and view transitions. Full Article All Episodes AI slop Blogging browsers view transitions Writing
ge 627: Getting Comfortable with the Struggle and Vibe Driven Development By shoptalkshow.com Published On :: Mon, 05 Aug 2024 08:52:17 +0000 Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future? Full Article All Episodes cloudflare workers database struggle
ge 641: Passkey Usage, Writing Code with a Bot, and What’s Up With Java? By shoptalkshow.com Published On :: Mon, 11 Nov 2024 10:03:26 +0000 We've got a few leftovers from Halloween to process, what's been happening with Passkeys in late 2024, have you tried to write HTML faster than a bot can suggest it to you, CSS anchor positioning and popover polyfills, scroll driven animation thoughts, CSS nesting, and what's the reason for Java? Full Article All Episodes CSS Nesting Halloween Java passkeys Scroll Driven Animation
ge Can Chennai change its energy consumption patterns? By www.thehindu.com Published On :: Fri, 05 Dec 2014 17:09:43 +0530 In creating energy-efficient cities, India will do well to model its development on its own age-old techniques, says Durganand Balsavar Full Article Property Plus
ge Change and culture By www.thehindu.com Published On :: Fri, 12 Dec 2014 20:06:36 +0530 We can’t just adopt renewable energy models imported from Europe. Any change has to address Chennai’s unique cultural and economic baggage Full Article Green Living
ge Geyser era By www.thehindu.com Published On :: Fri, 06 Mar 2015 21:46:07 +0530 Exploring alternatives is mandatory if we want a greener future. Full Article Green Living
ge Unsuccessful malls on the verge of closure By www.thehindu.com Published On :: Fri, 04 Sep 2015 15:40:22 +0530 Poor management practices have resulted in many malls across the country becoming unviable spaces. Full Article Property Plus
ge The management of sludge By www.thehindu.com Published On :: Fri, 18 Dec 2015 18:55:03 +0530 There is a need for building bye-laws to insist on a range of on-plot sanitation as mandatory, depending on the location and the groundwater table. Full Article Property Plus
ge Challenges on the water front By www.thehindu.com Published On :: Fri, 01 Jan 2016 15:37:55 +0530 Weather anomalies, pollution, mindless exploitation… the problems are many but solutions are available. Full Article Property Plus
ge Cold plunges, hot saunas, smoothies, and fasting By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 21:49:00 +0530 Fitness regimen on the go Full Article Pulse
ge Carbon credits to boost incomes of Jharkhand village farmers By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 The Birsa Harit Gram project serves as a potential model for agro-forestry, which is gaining ground because the buyers of carbon credits prefer — pay a premium — for credits based on Nature Based Solution, as opposed to offsetting projects like renewable energy or projects like carbon capture. Full Article Clean Tech
ge ITC wants a bigger FMCG slice By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:00:00 +0530 The Sanjiv Puri-led group looks set to feed on the success of its brand extension strategy Full Article Corporate File
ge Idukki project leapfrogs ‘endangered’ list By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:06:56 +0530 Local enthusiasts pitch in to bring amphibian species back from the brink of extinction Full Article Clean Tech
ge Flat organisation believers: Can you imagine a world without managers? By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:24:36 +0530 What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important? Full Article Corporate File
ge New venture Zerofifty from ad veterans wants to simplify the agency model By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 10:46:58 +0530 ZeroFifty Mediaworks, set up by three ad veterans, wants to bring in Bandra vibes into the agency model Full Article Marketing
ge Brand expertise and heritage bubbling in a moka pot By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 18:32:59 +0530 Lessons from European brands that have won consumers’ mindspace for long years Full Article Marketing
ge Galathea Bay: New major port can be game changer By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 19:56:00 +0530 Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route Full Article Logistics
ge Getting the gig economy to care for its backbone By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:25:45 +0530 Why startups in India cannot afford to take a hands-off approach towards the armies of gig workers they have created Full Article Emerging Entrepreneurs
ge Lure of emergent tech ventures By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 14:53:32 +0530 Venture Catalysts backs startups that come with unique solutions and first-mover advantages Full Article Emerging Entrepreneurs
ge Why peer-to-peer lending has RBI on edge By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 15:51:18 +0530 Forced to drop many of its attractive features, peer-to-peer lending faces an existential crisis in India Full Article Current Account
ge ₹200-crore decentralised green hydrogen scheme By www.thehindubusinessline.com Published On :: Sun, 10 Nov 2024 20:16:33 +0530 Decentralised use of green hydrogen could include cooking, off-grid electricity generation Full Article Clean Tech
ge Delhi women to get monthly stipend of ₹1,000 soon: Kejriwal By www.thehindu.com Published On :: Tue, 05 Nov 2024 01:13:29 +0530 Full Article Delhi