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Systole and Diastole: A Metaphor for Living

In this narrative medicine essay, a physician finds in the motion of diastole, the process of letting go and filling up, an apt metaphor for how to handle the burnout, anxiety, and depression of medical training.




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The Sound of Silence—When There Are No Words

In this narrative medicine essay, a surgeon and palliative care physician describes the isolating silence that she felt her after the slaying of her father in Egypt when she was 18 years old and how that lingering silence has come to guide her when sitting with patients, when there are no words.




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A paper-based SERS assay for sensitive duplex cytokine detection towards the atherosclerosis-associated disease diagnosis

J. Mater. Chem. B, 2020, 8,3582-3589
DOI: 10.1039/C9TB02469G, Paper
Chunxia Li, Yuan Liu, Xiaoyan Zhou, Yuling Wang
Novel SERS based sensing assay was built by combining nanoporous membrane with sandwich immunoassay for duplex cytokines detection. It can be used as a promising candidate for clinical application due to its excellent performance in human serum.
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An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy

J. Mater. Chem. B, 2020, 8,3316-3326
DOI: 10.1039/C9TB02327E, Review Article
Jie Lin, Jianping Zheng, Aiguo Wu
Circulating tumor cells (CTCs) are circulating cancer cells that shed from tumor tissue into blood vessels and circulate in the blood to invade other organs, which results in fatal metastases. Surface-enhanced Raman scattering (SERS) has great potentials in CTCs detection.
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A dual-targeted CeO2–DNA nanosensor for real-time imaging of H2O2 to assess atherosclerotic plaque vulnerability

J. Mater. Chem. B, 2020, 8,3502-3505
DOI: 10.1039/C9TB02459J, Communication
Zhenhua Liu, Yujie Cao, Xiaona Zhang, Huazhen Yang, Yujie Zhao, Wen Gao, Bo Tang
A novel dual-targeted CeO2–DNA nanosensor by modifying with folic acid (FA) and CD36 antibody was designed.
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Electrodeposition of nickel nanostructures using silica nanochannels as confinement for low-fouling enzyme-free glucose detection

J. Mater. Chem. B, 2020, 8,3616-3622
DOI: 10.1039/C9TB02472G, Paper
Jialian Ding, Xinru Li, Lin Zhou, Rongjie Yang, Fei Yan, Bin Su
This work reports an enzyme-free glucose sensor based on nickel nanostructures electrodeposited on a fluorine-doped tin oxide (FTO) electrode modified with a silica nanochannel membrane (SNM).
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Aggregation-induced emission luminogens for RONS sensing

J. Mater. Chem. B, 2020, 8,3357-3370
DOI: 10.1039/C9TB02310K, Review Article
Jun Dai, Chong Duan, Yu Huang, Xiaoding Lou, Fan Xia, Shixuan Wang
The development of AIE bioprobes for RONS sensing in living systems is now summarized. We discuss some representative examples of AIEgen based bioprobes in terms of their molecular design, sensing mechanism and sensitive sensing in vitro and in vivo.
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Graphene–nucleic acid biointerface-engineered biosensors with tunable dynamic range

J. Mater. Chem. B, 2020, 8,3623-3630
DOI: 10.1039/C9TB02388G, Paper
Zhifeng Zhao, Hao Yang, Wenyue Zhao, Sha Deng, Kaixiang Zhang, Ruijie Deng, Qiang He, Hong Gao, Jinghong Li
Programmed biosensors with tunable quantification range and higher specificity have been constructed by engineering graphene–nucleic acid biointerfaces.
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Biomolecular detection, tracking, and manipulation using a magnetic nanoparticle-quantum dot platform

J. Mater. Chem. B, 2020, 8,3534-3541
DOI: 10.1039/C9TB02481F, Paper
Kalpesh D. Mahajan, Gang Ruan, Greg Vieira, Thomas Porter, Jeffrey J. Chalmers, R. Sooryakumar, Jessica O. Winter
Fluorescent and magnetic materials play a significant role in biosensor technology, enabling sensitive quantification and separations with applications in diagnostics, purification, quality control, and therapeutics.
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Ti3C2Tx MXene-derived TiO2/C-QDs as oxidase mimics for the efficient diagnosis of glutathione in human serum

J. Mater. Chem. B, 2020, 8,3513-3518
DOI: 10.1039/C9TB02478F, Communication
Zhaoyong Jin, Gengfang Xu, Yusheng Niu, Xiaoteng Ding, Yaqian Han, Wenhan Kong, Yanfeng Fang, Haitao Niu, Yuanhong Xu
A Ti3C2Tx MXene-derived TiO2/C-QD oxidase mimic was developed and used for the efficient diagnosis of glutathione in human serum.
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Recent advances of tissue-interfaced chemical biosensors

J. Mater. Chem. B, 2020, 8,3371-3381
DOI: 10.1039/C9TB02476J, Review Article
Chuanrui Chen, Yue Guo, Peining Chen, Huisheng Peng
This review discusses recent advances of tissue interfaced chemical biosensors, highlights current challenges and gives an outlook on future possibilities.
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Stretchable gold fiber-based wearable electrochemical sensor toward pH monitoring

J. Mater. Chem. B, 2020, 8,3655-3660
DOI: 10.1039/C9TB02477H, Paper
Ren Wang, Qingfeng Zhai, Yunmeng Zhao, Tiance An, Shu Gong, Zhirui Guo, QianQian Shi, Zijun Yong, Wenlong Cheng
A stretchable gold fiber-based wearable electrochemical pH two-electrodes sensing system for human health monitoring.
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Nucleoside-based fluorescent carbon dots for discrimination of metal ions

J. Mater. Chem. B, 2020, 8,3640-3646
DOI: 10.1039/C9TB02758K, Paper
Tieli Zhou, Jinyi Zhang, Biwu Liu, Shihong Wu, Peng Wu, Juewen Liu
Using nucleosides and citrate as starting materials, a series of fluorescent carbon dots were synthesized showing different quenching properties by metal ions for their detection by a sensor array.
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Advances in functional nucleic acid based paper sensors

J. Mater. Chem. B, 2020, 8,3213-3230
DOI: 10.1039/C9TB02584G, Review Article
Rudi Liu, Erin M. McConnell, Jiuxing Li, Yingfu Li
This article provides an extensive review of paper-based sensors that utilize functional nucleic acids, particularly DNA aptamers and DNAzymes, as recognition elements.
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Boosting biomolecular interactions through DNA origami nano-tailored biosensing interfaces

J. Mater. Chem. B, 2020, 8,3606-3615
DOI: 10.1039/C9TB02439E, Paper
Iene Rutten, Devin Daems, Jeroen Lammertyn
Nano-tailored DNA origami designs nanostructure the bioreceptor layer of encoded microparticles in an innovative microfluidic platform, hereby boosting biomolecular interactions.
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Recent development of biofuel cell based self-powered biosensors

J. Mater. Chem. B, 2020, 8,3393-3407
DOI: 10.1039/C9TB02428J, Review Article
Shuai Hao, Xiaoxuan Sun, He Zhang, Junfeng Zhai, Shaojun Dong
BFC-based SPBs have been used as power sources for other devices and as sensors for detecting toxicity and BOM.
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From design to applications of stimuli-responsive hydrogel strain sensors

J. Mater. Chem. B, 2020, 8,3171-3191
DOI: 10.1039/C9TB02692D, Review Article
Dong Zhang, Baiping Ren, Yanxian Zhang, Lijian Xu, Qinyuan Huang, Yi He, Xuefeng Li, Jiang Wu, Jintao Yang, Qiang Chen, Yung Chang, Jie Zheng
Stimuli-responsive hydrogel strain sensors that synergize the advantages of both hydrogel and smart functional materials have attracted increasing interest from material design to emerging applications in health monitors and human–machine interfaces.
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Flexible and stretchable dual mode nanogenerator for rehabilitation monitoring and information interaction

J. Mater. Chem. B, 2020, 8,3647-3654
DOI: 10.1039/C9TB02466B, Paper
Zhuo Liu, Qiang Zheng, Yue Shi, Lingling Xu, Yang Zou, Dongjie Jiang, Bojing Shi, Xuecheng Qu, Hu Li, Han Ouyang, Ruping Liu, Yuxiang Wu, Yubo Fan, Zhou Li
Sensors with flexibility and stretchability are the key functional modules of converter between mechanical motions and electric signals for intelligent robots and rehabilitation training systems.
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Genetically encoded light-up RNA aptamers and their applications for imaging and biosensing

J. Mater. Chem. B, 2020, 8,3382-3392
DOI: 10.1039/C9TB02668A, Review Article
Puchakayala Swetha, Ze Fan, Fenglin Wang, Jian-Hui Jiang
Light-up RNA aptamers and their applications in bioimaging and biosensing of small ligands and biomacromolecules are described.
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Structurally coloured contact lens sensor for point-of-care ophthalmic health monitoring

J. Mater. Chem. B, 2020, 8,3519-3526
DOI: 10.1039/C9TB02389E, Paper
Yunlong Wang, Qilong Zhao, Xuemin Du
A structurally coloured contact lens sensor has been developed for point-of-care diagnosis of eye diseases.
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Wearable biochemical sensors for human health monitoring: sensing materials and manufacturing technologies

J. Mater. Chem. B, 2020, 8,3423-3436
DOI: 10.1039/C9TB02474C, Review Article
Guanglei Li, Dan Wen
Recent achievements and challenges in materials and manufacturing technologies of sensing electrodes in wearable biosensors have been highlighted.
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Silver nanoprism-based plasmonic ELISA for sensitive detection of fluoroquinolones

J. Mater. Chem. B, 2020, 8,3667-3675
DOI: 10.1039/C9TB02776A, Paper
Meifang Yuan, Qirong Xiong, Ganggang Zhang, Zhijuan Xiong, Daofeng Liu, Hongwei Duan, Weihua Lai
Silver nanoprism-based plasmonic ELISA for qualitative and quantitative detection of fluoroquinolones.
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Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells

J. Mater. Chem. B, 2020, 8,3408-3422
DOI: 10.1039/C9TB02457C, Review Article
Pi Ding, Zhili Wang, Zeen Wu, Weipei Zhu, Lifen Liu, Na Sun, Renjun Pei
This paper summarizes various aptamer-functionalized nanostructured interfaces for the detection and release of circulating tumor cells.
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Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP

J. Mater. Chem. B, 2020, 8,3661-3666
DOI: 10.1039/C9TB02319D, Paper
Xiaomeng Zhou, Juanmin Li, Li-Li Tan, Qiang Li, Li Shang
Schematic illustration of PDI@ZIF-8 nanocomposite synthesis and ratiometric fluorescence assay for ATP sensing. 2-MIm: 2-methylimidazole.
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Nanomaterial-based gas sensors used for breath diagnosis

J. Mater. Chem. B, 2020, 8,3231-3248
DOI: 10.1039/C9TB02518A, Review Article
Xinyuan Zhou, Zhenjie Xue, Xiangyu Chen, Chuanhui Huang, Wanqiao Bai, Zhili Lu, Tie Wang
Gas-sensing applications commonly use nanomaterials (NMs) because of their unique physicochemical properties, including a high surface-to-volume ratio, enormous number of active sites, controllable morphology, and potential for miniaturisation.
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Stretchable and tough conductive hydrogels for flexible pressure and strain sensors

J. Mater. Chem. B, 2020, 8,3437-3459
DOI: 10.1039/C9TB02570G, Review Article
Zhenwu Wang, Yang Cong, Jun Fu
This review summarises recent advances in stretchable and tough conductive hydrogel sensors for wearable and implantable devices.
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Nanomaterial-based biosensors for DNA methyltransferase assay

J. Mater. Chem. B, 2020, 8,3488-3501
DOI: 10.1039/C9TB02458A, Review Article
Fei Ma, Qian Zhang, Chun-yang Zhang
We review the recent advances in the development of nanomaterial-based biosensors for DNA methyltransferase assay.
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A perylenetetracarboxylic dianhydride and aniline-assembled supramolecular nanomaterial with multi-color electrochemiluminescence for a highly sensitive label-free immunoassay

J. Mater. Chem. B, 2020, 8,3676-3682
DOI: 10.1039/C9TB02368B, Paper
Wei Zhang, Yue Song, Yunyun Wang, Shuijian He, Lei Shang, Rongna Ma, Liping Jia, Huaisheng Wang
A novel multi-color ECL nanomaterial assembled from 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) and aniline (An) was used for highly sensitive label-free CEA detection.
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Toehold-regulated competitive assembly to accelerate the kinetics of graphene oxide-based biosensors

J. Mater. Chem. B, 2020, 8,3683-3689
DOI: 10.1039/C9TB02454A, Paper
Huan Du, Junbo Chen, Jie Zhang, Rongxing Zhou, Peng Yang, Xiandeng Hou, Nansheng Cheng
With toehold-regulation, the kinetics of graphene oxide-based biosensors can be accelerated.
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Assessing the range of enzymatic and oxidative tunability for biosensor design

J. Mater. Chem. B, 2020, 8,3460-3487
DOI: 10.1039/C9TB02666E, Review Article
Hattie C. Schunk, Derek S. Hernandez, Mariah J. Austin, Kabir S. Dhada, Adrianne M. Rosales, Laura J. Suggs
This review aims to inspire novel biosensor design by addressing materials chemistries through the lense of enzymatic and oxidative susceptibility in the spectra of inflammatory disease biomarkers.
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A general strategy for designing NIR-II emissive silk for the in vivo monitoring of an implanted stent model beyond 1500 nm

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02685A, Paper
Zhiming Deng, Junqing Huang, Zhenluan Xue, Mingyang Jiang, Youbin Li, Songjun Zeng
The NIR-II emissive silk is explored by a general feeding strategy for NIR-II imaging guided in situ monitoring of the implanted biological stent model made from silk.
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Introduction to Biosensors

J. Mater. Chem. B, 2020, 8,3168-3170
DOI: 10.1039/D0TB90051F, Editorial
Ning Gu, Shaoqin Liu
Shaoqin Liu and Ning Gu, Journal of Materials Chemistry B themed issue on Biosensors.
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Recent progress of SERS optical nanosensors for miRNA analysis

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00280A, Review Article
Yudie Sun, lin shi, Lan Mi, Ruiyan Guo, Tao Li
This review focus on emerging applications of surface-enhanced Raman spectroscopy (SERS) optical nanosensors for miRNA analysis, in which the key enhancement factors of SERS signal, i.e. SERS-active substrates, SERS nanoprobes...
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Stable Anchoring of Bacteria-based Protein Nanoparticles for Surface Enhanced Cell Guidance

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00702A, Paper
Open Access
Imma Ratera, Marc Martínez-Miguel, Adriana Kyvik, Lena Montaña, Albert Martínez-Moreno, Olivia Cano-Garrido, Elena Garcia-Fruitos, Esther Vazquez, Nora Ventosa, Judith Guasch, Jaume Veciana, Antonio Villaverde
In tissue engineering, biological, physical, and chemical inputs have to be combined to properly mimic cellular environments and successfully build artificial tissues, which can be designed to fulfil different biomedical...
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Rapidly dissolving microneedle patch for synergistic gene and photothermal therapy of subcutaneous tumor

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00105H, Paper
Qinan Xu, Xinfang Li, Peng Zhang, Youxiang Wang
Synergistic gene and photothermal therapy conducted by p53 DNA/IR820 MN patch may be a promising strategy for subcutaneous tumor treatments.
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Mechanically robust enzymatic degradable shape memory polyurethane urea with rapid recovery response induced by NIR

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00798F, Paper
Xin Li, Wenkai Liu, Yaomin Li, Wanling Lan, Daiguo Zhao, Hecheng Wu, Yuan Feng, Xueling He, Zhen Li, Jiehua Li, Feng Luo, Hong Tan
Biodegradable shape memory polymers have great potential using in minimally invasive surgical procedures. Herein, a series of shape memory polyurethanes (SMPUs) containing chymotrypsin-inspired chain extenders with adjustable mechanical properties and...
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Design principles and fundamental understanding of biosensors for amyloid-β detection

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00344A, Review Article
Yanxian Zhang, Baiping Ren, Dong Zhang, Yonglan Liu, Mingzhen Zhang, Chao Zhao, Jie Zheng
Aβ as biomarker in Alzheimer’s disease (AD) drives the significant research efforts for developing different biosensors with different sensing strategies, materials, and mechanisms for Aβ detection.
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Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00874E, Paper
Haijie Han, Qichuan Yin, Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji, Xingchao Shentu
Corneal neovascularization (CNV) is one of the leading risk factors for vision loss. Anti-angiogenic drugs can theoretically be extended to the treatment of CNV. However, the application of these drugs...
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Multi-Stimuli Responsive Polymeric Prodrug Micelles for Combined Chemotherapy and Photodynamic Therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00539H, Paper
Cheng Hu, Weihua Zhuang, Tao Yu, Liang Chen, Zhen Liang, Gaocan Li, Yunbing Wang
Nowadays, cancer therapy faces severe challenges on boosting therapeutic efficiency and reducing the side effects of drugs. To overcome these challenges, herein multifunctional polymeric prodrug micelles with combining chemotherapy and...
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Biomimetic Immunomagnetic Gold Hybrid Nanoparticles Coupled with Inductively Coupled Plasma Mass Spectrometry for the Detection of Circulating Tumor Cells

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00403K, Paper
Zhimin Chang, Hang Zhou, Chao Yang, Rui Zhang, Qiannan You, Ruhong Yan, Li Li, Mingfeng Ge, Yuguo Tang, Wen-fei Dong, Zheng Wang
Immunomagnetic beads are important tools for the isolation and detection of circulating tumor cells (CTCs). However, the current immunomagnetic bead technique provides poor CTC separation purity due to nonspecific binding...
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Fluorinated porphyrin-based theranostics for dual imaging and chemo-photodynamic therapy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00083C, Paper
Huaibin Zhang, Shaowei Bo, Kai Zeng, Jie Wang, Yu Li, Zhigang Yang, Xin Zhou, Shizhen Chen, Zhong-Xing Jiang
A modular strategy facilitates the convenient and standardized preparation of multifunctional theranostics for cancer therapy.
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Thin platelet-like COF nanocomposites for blood brain barrier transport and inhibition of brain metastasis from renal cancer

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00724B, Paper
Guiyang Zhang, Bo Jiang, Chunyong Wu, Yanfeng Liu, Yidan He, Xin Huang, Wei Chen, Kai Xi, Hongqian Guo, Xiaozhi Zhao, Xudong Jia
A drug-loaded polymer–COF nanocomposite has been developed to cross the blood brain barrier and treat brain metastasis from renal cancer.
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A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02156F, Paper
Mohammad-Ali Shahbazi, Neha Shrestha, Malgorzata Karolina Pierchala, Firoz Babu Kadumudi, Mehdi Mehrali, Masoud Hasany, Véronique Préat, Sander Leeuwenburgh, Alireza Dolatshahi-Pirouz
A polymeric gum has been developed herein, which combines high stretchability and self-healing capacity with a bioactivity that can target and eliminate bacterial infections and inflammations.
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Phosphates-responsive 2D-Metal─Organic-Framework-Nanozymes for Colorimetric Detection of Alkaline Phosphatase

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/C9TB02542A, Paper
Xiaoyu Wang, Xiaoqian Jiang, Hui Wei
In this study, a simple colorimetric method with tunable dynamic range for alkaline phosphatase (ALP) activity assay was developed by using peroxidase-mimicking two-dimensional-metal─organic-framework (2D-MOF). Phosphates including pyrophosphate (PPi), ATP, and...
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Seedless Synthetic Branched Gold Nanoshell for Chemo-thermal Antitumor Therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00891E, Paper
Lei Li, Yihan Fu, Zichuang Xu, Xuwu Zhang, Zining Hao, Yaqian He, Wenbin Gao, Dawei Gao
Gold nanomaterials (GNMs) were used in photothermal therapy due to their superior optical properties and excellent biocompatibility. However, the complex preparation process of seed-mediated growth limits further clinical applications of...
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Controllable hydrogen bonded self-association for the formation of multifunctional antimicrobial materials

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00875C, Paper
Lisa White, Jessica E. Boles, Nyasha Allen, Luke Alesbrook, J. Mark Sutton, Charlotte Hind, Kira Hilton, Laura R. Blackholly, Rebecca Ellaby, George Williams, Daniel P Mulvihill, Jennifer Ruth Hiscock
SSAs are a class of Supramolecular Self-associating Amphiphilic salt, the anionic component of which contains a covalently bound hydrogen bond donor-acceptor motif. This results in a monomeric unit which can...
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A waterborne polyurethane 3D scaffold containing PLGA with a controllable degradation rate and an anti-inflammatory effect for potential applications in neural tissue repair

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00656D, Paper
Bohong Du, Hang Yin, Yue Chen, Weiwei Lin, Yanchao Wang, Daiguo Zhao, Gang Wang, Xueling He, Jiehua Li, Zhen Li, Feng Luo, Hong Tan, Qiang Fu
3D connected porous LGPU scaffolds with adjustable degradation and a strong anti-inflammatory effect were prepared for neural tissue repair.
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Glutathione- and light-controlled generation of singlet oxygen for triggering drug release in mesoporous silica nanoparticles

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00636J, Paper
Roy C. H. Wong, Dennis K. P. Ng, Wing-Ping Fong, Pui-Chi Lo
An activatable phthalocyanine-based photosensitiser and a singlet-oxygen-triggered doxorubicin releasing system have been incorporated into mesoporous silica nanoparticles, which can release the encapsulated doxorubicin in a controllable manner.
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Multivalent cationic dendrofullerenes for gene transfer: synthesis and DNA complexation

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00113A, Paper
Beatriz M. Illescas, Alfonso Pérez-Sánchez, Araceli Mallo, Ángel Martín-Domenech, Ignacio Rodríguez-Crespo, Nazario Martín
Non-viral nucleic acid vectors able to display high transfection efficiencies with low toxicity and overcoming the multiple biological barriers are needed to further develop the clinical applications of gene therapy.
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Progress in biomimetic leverages for marine antifouling using nanocomposite coatings

J. Mater. Chem. B, 2020, 8,3701-3732
DOI: 10.1039/C9TB02119A, Review Article
Mohamed S. Selim, Sherif A. El-Safty, Mohamed A. Shenashen, Shimaa A. Higazy, Ahmed Elmarakbi
Because of the environmental and economic casualties of biofouling on maritime navigation, modern studies have been devoted toward formulating advanced nanoscale composites in the controlled development of effective marine antifouling self-cleaning surfaces.
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