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Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




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LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




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MicroRNA let-7c (MIRLET7C; let-7c), miR-99a and miR-125b as prognostic markers of luminal breast cancer

Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor–positive luminal breast cancers.




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Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




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Nanomolar-scale, high throughput chemical synthesis of drug-like molecules

A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds.




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




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Cancer Gene Therapy




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Two-dimensional optical edge detection




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy




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Ex vivo pulsed dendritic cell vaccination against cancer




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Acta Pharmacologica Sinica




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Microbiota and colorectal cancer: colibactin makes its mark




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Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial




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Nanoscale nights of COVID-19




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Probing nanoscale fluctuation of ferromagnetic meta-atoms with a stochastic photonic spin Hall effect




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Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




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A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system




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Recovery after traumatic thoracic- and lumbar spinal cord injury: the neurological level of injury matters




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Erythrocytosis with <i>JAK2</i> GGCC_46/1 haplotype and without <i>JAK2</i> V617F mutation is associated with <i>CALR</i> rs1049481_G allele




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Peter Ward: 'Membership organisations can thrive and prosper'




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Fixed orthodontic appliances: a practical guide




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Noncanonical amino acids on display




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Why There is No Team Modi – Because There Can Only Be a Brand Modi, The Telegraph

In December 2018, I was having lunch with an entrepreneur-friend who works closely with the Central Government. The BJP had just lost state elections in Madhya Pradesh, Rajasthan and Chattisgarh, putting three Chief Ministers out of office and out of work. I suggested to the entrepreneur that when the Prime Minister won re-election the following [...]




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Evaluation of an AI system for the detection of diabetic retinopathy from images captured with a handheld portable fundus camera: the MAILOR AI study




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Possible consequences of the COVID-19 pandemic on the use of biospecimens from cancer biobanks for research in academia and bioindustry




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Defense Playbook for Campaigns

The 2018 National Defense Strategy (NDS) is predicated on a single organizing principle: America’s military pre-eminence is rapidly eroding. This is not a new concept. For years, experts have warned that the economic and technological advancements of U.S. adversaries, coupled with the 2008 financial crisis and America’s focus on peripheral conflicts, have caused a decline in America’s military dominance. 

In this context, the advances of near-peer competitors such as China and Russia have created plausible “theories of victory” in potential conflicts across Eastern Europe and East Asia. Competitors’ unaddressed improvements in strategic innovation, economic investment, and dual-use technology increases the risk of conflict and strains the U.S. alliance system. It is urgent that the United States reestablish and maintain credible deterrents against these near-peer competitors. After decades of focusing on post-Cold War ‘shaping’ operations, the American military needs to reinvigorate for full spectrum great power competition.

This report is intended as a blueprint on how to begin that process from graduate students at the Belfer Center for Science and International Affairs at Harvard University. Contained inside are 12 memorandums. Each provides a high-level overview and specific recommendations on a key issue of American defense policy. 




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Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




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Oil's Collapse Is a Geopolitical Reset In Disguise

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  




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Cutoff point estimation for serum vitamin D concentrations to predict cardiometabolic risk in Brazilian children




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Relationship between markers of malnutrition and clinical outcomes in older adults with cancer: systematic review, narrative synthesis and meta-analysis




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Central catheter removal timing and growth patterns in preterm infants




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COVID-19 pandemic: the effects of quarantine on cardiovascular risk




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European Journal of Clinical Nutrition




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Organizational Responses to COVID-19 and Climate Change: A Conversation with Rebecca Henderson

Rebecca Henderson, the John and Natty McArthur University Professor at Harvard University, shared her perspectives on how large organizations are changing in response to the coronavirus pandemic and climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”




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Global Problem, Local Solutions

The Arctic Initiative is pairing policy and science scholars with local experts to find practical climate solutions.




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How COVID-19 is Testing American Leadership

Joseph Nye suggests that a new U.S. administration might take a leaf from the success of the post-1945 American presidents that are described in Do Morals Matter? Presidents and Foreign Policy from FDR to Trump. The United States could launch a massive COVID-19 aid program like the Marshall Plan.




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Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




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The Arctic is Transforming… Can We?

Joel Clement describes how the Arctic is transforming into a warmer, wetter, and less predictable climate state, what the consequences are for the Arctic's indigenous inhabitants, and what measures can be taken to build resilience.




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Carbon Taxes vs. Cap and Trade: Theory and Practice

How do the two major approaches to carbon pricing compare on relevant dimensions, including efficiency, cost-effectiveness, and distributional equity? This paper addresses this question by drawing on theories of policy instrument choice pertaining to the attributes — or merits — of the instruments.




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HPCA Hosts COP25 Side Event Focused on Reducing GHG Emissions through Carbon Pricing

As negotiators from around the world arrived in Madrid for the second week of the 25th UN Climate Change Conference (COP-25), the Harvard Project on Climate Agreements hosted an official COP side event on Dec. 9 focusing on the potential for reducing greenhouse-gas (GHG) emissions through the use of carbon pricing.