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Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield

Org. Biomol. Chem., 2024, 22,3009-3018
DOI: 10.1039/D4OB00211C, Paper
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
A single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective enhancement of (6–4) photoproduct formation in dithymine dinucleotides driven by specific sugar puckering

Org. Biomol. Chem., 2024, 22,3025-3034
DOI: 10.1039/D4OB00279B, Paper
Jouda Jakhlal, Clément Denhez, Stéphanie Coantic-Castex, Agathe Martinez, Dominique Harakat, Thierry Douki, Dominique Guillaume, Pascale Clivio
Evidence is presented that (6–4) photoproduct formation between two thymine residues in dinucleotide analogues is significantly and specifically enhanced when the 5''- and 3''-end sugar puckering are mainly north and south, respectively.
The content of this RSS Feed (c) The Royal Society of Chemistry




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As the price of aviation turbine fuel soars, airlines’ finances spin out of control




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‘The challenge was in getting the aircraft’s custom clearance’

Private jet operator JetSetGo’s CEO Kanika Tekriwal describes the intricacies of directly importing and leasing an aircraft




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Breaking down airline engineering and maintenance

An aircraft has three critical phases; induction, in-service and redelivery




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Airlines’ performance metrics may need an overhaul

It may be time to revisit RASK, CASK metrics; benchmarking based on cost drivers can boost an airline’s performance




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Compliance with regulation: Staying ahead is key




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Zomato users can now schedule order 2 days in advance

Zomato’s order scheduling is available at more than 35,000 restaurants across 30 cities




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Hong Kong unveils responsible AI framework for financial sector

Hong Kong’s responsible AI framework comes amid increasing international competition and tensions affecting access to AI technology




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Meta builds AI search engine to cut Google, Bing reliance, the Information reports

The Facebook-owner currently relies on Google and Bing search engines to give users answers on news, stocks and sports




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WHO certifies Egypt as malaria-free; calls it ‘historic feat’ ending ancient scourge

Globally, 44 countries and one territory have now been certified as malaria-free




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Acute Flaccid Paralysis surveillance as a crucial defence against polio in India | Explained

India needs to continue efforts to maintain its polio-free status, and AFP surveillance has to remain a cornerstone of its strategy




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Why did the Centre sanction a 50% hike in prices of commonly-used drugs?

According to the government the recent 50% hike in prices of eight drugs was sanctioned keeping in mind the larger public interest and to ensure continued availability of drugs




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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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National Pharmaceutical Pricing Authority directs firms to cut prices of three anti-cancer drugs

Govt. had earlier scrapped customs duty on Trastuzumab, Osimertinib and Durvalumab and also reduced GST rates on them




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As breast cancer incidence rises, doctors raise importance of early detection, need for women to be breast aware

Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors




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What is breast density and how is it associated with cancer? Explained

Breast density matters because of two main reasons: it may make it harder to detect signs of cancer on a mammogram, and it is linked with an increased risk of breast cancer




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Glioblastoma: why immunotherapy may offer hope for brain cancer patients

Recent trials have shown that immunotherapy can safely be delivered through injections into the cerebrospinal fluid; scientists are now exploring how to adapt these methods to penetrate the tumour more effectively




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'I have danced with Sushmita Sen!'

'She got really close, and I was like, oh Miss Universe and me dancing!'




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'Women don't have to only sing and dance'

'When you are new, you don't know how the industry works'. 'But when you know where you are headed, the possibilities of being conned or facing unpleasant instances is reduced.'




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Making Prabhas And Diljit Dance

'Diljit and Prabhas are so similar -- very humble, down-to-earth, extremely shy introverts and at the same time, extremely talented guys.'




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'Happy Performances Are Usually Ignored'

'If people think that films that are happy or light, or comedy or romance are not substantial, that's not true.''I was really happy when this award was given for Thiruchitrambalam because it highlights that.'





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A follow up to obtaining 60fps scrolling performance

60fps scrolling article got quite a few people excited but also a few smart people to point out some flaws in the approach. I was planning to just update the original article but I’ve compiled so much info about this topic that I thought it would be better to do a follow up article and … Continue reading "A follow up to obtaining 60fps scrolling performance"




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The Role of Artificial Intelligence in Enhancing Software Performance and Security

Sachin Samrat Medavarapu, a recognized leader in AI-enhanced security and performance optimization, has built an impressive career marked by a series of significant achievements.




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Dubai siblings Jainam and Jivika who own JioHotstar domain, have THIS offer for Mukesh Ambani's Reliance

Dubai-based siblings have seemingly decided to offer the domain to Reliance free of charge, according to their website.




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‘Dance matters most’

Actress and up-and-coming dancer Mahalakshmi S. performs in the city today




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Dissolving the dissonance

In times when parochial forces are gathering momentum and market pressure could be felt on classical dance forms, abhinaya remains the tool with which performers can celebrate the idea of India.




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The lion dance

Vasanthalakshmi talks about the Simhanandini Chitra Natyam to be performed in memory of M.V. Narasimhachari.




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A refined performance

Sailaja’s Kuchipudi recital in New Delhi was a triumph of understatement.




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When the dancer sketched with her feet

Lasya’s fitting tribute to her father Narasimhachari.




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The boy brigade storming dance bastion

After years of absence, male dancers seem to be back on the stage with talent and conviction. With this new trend, dance seems to have made a step towards gender equality




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Dance for happiness

The Thimphu Tshechu in Bhutan, offers a spiritual uplift through dance.




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Arundhati Patwardhan and Manasi Jog traced Sant Tukaram’s journey through dance

The two Bharatanatyam dancers paid tribute to M.K. Saroja through their abhang-based performance




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Remembering dancer and guru M.K. Saroja

M.K. Saroja, who passed away recently, remained committed to artistic values all her life




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Kanak Rele was a doyenne of Mohiniyattam who redefined and reinterpreted the traditional dance form of Kerala

In her passing, Mohiniyattam has lost a crusader who widened its repertoire and gave it a new aesthetics rooted in Kerala




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Life skill coaching, moving from experiential avoidance to psychological flexibility




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Resilience and relevance, a current need




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PM KISAN Yojana | FM Nirmala Sitharaman says 11.8 crore farmers receive financial assistance

“The government under the leadership of Prime Minister Narendra Modi is addressing systematic inequalities, which have plagued the society,” Finance Minister Nirmala Sitharaman said.




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A royal renaissance

India’s old zamindari residences are being converted into boutique hotels, offering a glimpse of past glory and heritage




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The Montblanc Summit 2 is ahead of its time

Montblanc Summit 2 comes with a range of features — and oozes style




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Smart university [electronic resource] : student surveillance in the digital age / Lindsay Weinberg.

Baltimore : Johns Hopkins University Press, [2024]




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Journal of Southeast Asian American education & advancement [electronic resource] : JSAAEA

Dorchester, Mass. : National Association for the Education and Advancement of Cambodian, Laotian, and Vietnamese Americans




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Nandini Reddy on ‘Anni Manchi Sakunamule’: I remembered the warmth of my grandmother’s palm

B V Nandini Reddy, director of the Telugu film ‘Anni Manchi sakunamule’, talks about understanding relationships across age groups and what she learnt from Sooraj Barjatya films




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Reliance Retail unveils new JioBook priced at ₹16,499

JioBook aims to empower learners of all ages with advanced features and seamless connectivity options.



  • Computers & Laptops

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Absent history : the untold story of Special Branch Operations in Singapore, 1915-1942 / Ban Kah Choon.

Singapore : Horizon Books, 2002.




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An-My Lê : between two rivers = giữa hai giòng sông = entre deux rivières / [edited by] Roxana Marcoci ; [contributors, La Frances Hui, Joan Kee, Thy Phu, Caitlin Ryan, Monique Truong, Ocean Vuong, Xueli Wang].

New York : The Museum of Modern Art, [2023]




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Phèdre : tragédie / Racine ; édition présentée, annotée et commentée par Laurence Giavarini, Ancienne élève de l'E.N.S. de Fontenay Agrégée de Lettres modernes et Ève-Marie Rollinat-Levasseur

Paris : Larousse, [2004]




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Driving short distances / by Joff Winterhart.

London : Jonathan Cape, 2017.




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La guerra dei vulcani (2012) / directed by Francesco Patierno [DVD].

[Rome] : Luce Cinecittà, [2012]