Now available to order from the TRB Bookstore, the Highway Capacity Manual, Sixth Edition: A Guide for Multimodal Mobility Analysis (HCM) provides methods for quantifying highway capacity. In its current form, it serves as a fundamental reference on concepts, performance measures, and analysis techniques for evaluating the multimodal operation of streets, highways, freeways, and off-street pathways. The Sixth Edition incorporates the latest research on highway capacity, quality of service, Active Traffic...

Additional new series for the 2020-2021 season will be announced at a later date.

In lieu of an attendance fee, ID is encouraging donations to nonprofit organizations that we support at the channel, including: the National Center for Missing & Exploited Children, National Network to End Domestic Violence, and One Love.

It's a long, long buildup to CEO's soliloquy, it's a long way to go

Knowledge 2020 With the long flights, late nights and early starts, IT conferences might seem endless. But with the shift to the online format becoming standard, for now at least, participants might be spared the trial of endurance.…

Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs.METHODS Male volunteers were screened for G6PD deficiency; 27 control and 10 G6PD-deficient volunteers each donated 1 RBC unit. After 42 days of refrigerated storage, autologous 51-chromium 24-hour posttransfusion RBC recovery (PTR) studies were performed. Metabolomics analyses of these RBC units were also performed.RESULTS The mean 24-hour PTR for G6PD-deficient subjects was 78.5% ± 8.4% (mean ± SD), which was significantly lower than that for G6PD-normal RBCs (85.3% ± 3.2%; P = 0.0009). None of the G6PD-normal volunteers (0/27) and 3 G6PD-deficient volunteers (3/10) had PTR results below 75%, a key FDA acceptability criterion for stored donor RBCs. As expected, fresh G6PD-deficient RBCs demonstrated defects in the oxidative phase of the pentose phosphate pathway. During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impaired glutathione homeostasis, and increased purine oxidation, as compared with G6PD-normal RBCs. In addition, there were significant correlations between PTR and specific metabolites in these pathways.CONCLUSION Based on current FDA criteria, RBCs from G6PD-deficient donors would not meet the requirements for storage quality. Metabolomics assessment identified markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TRIAL REGISTRATION ClinicalTrials.gov NCT04081272.FUNDING The Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation grant 71590, the National Blood Foundation, NIH grant UL1 TR000040, the Webb-Waring Early Career Award 2017 by the Boettcher Foundation, and National Heart, Lung, and Blood Institute grants R01HL14644 and R01HL148151.

The Town of Berlin Connecticut continues to raise property taxes in the face of a never-ending recession. The Berlin Property Owners Association has been speaking out against these increases in property taxes. Recorded herein are four speeches by residents of the Town of Berlin at the first Town Council meeting subsequent to the Town Council's approval of an increase in property taxes, resulting from giving raises to virtually all town employees, who are already very well compensated. Continue reading →

Chuck Todd tells Andrea Mitchell that Hillary Clinton will win the African-American and Hispanic vote in spite of the intellectual appeal of Bernie Sanders to liberal white voters Continue reading →

IBM Research today opened its second research location on the African continent and announced several new project collaborations in the areas of data driven healthcare, digital urban ecosystems and astronomy.

ENGIE, a global leader in energy transition, today announced a new initiative with IBM. This nonexclusive, technological and commercial alliance is designed to improve the management of cities by looking at patterns, event correlation, anomaly detection and real-time data across all parts of cities.

IBM announced today that it has been recognized as the winner in the Business Analytics category and the Enterprise Network Storage sub-category in CRN’s 2017 Annual Report Card (ARC) awards program. The Annual Report Card summarizes results from a comprehensive survey that details solution provider satisfaction across product innovation, support and partnership for the hardware, services and software vendors they team up with. The vendors with the highest ratings are named to the prestigious Annual Report Card list of winners and celebrated as best-in-class by their partners. The results also provide the IT vendor community with valuable feedback—directly from their solution providers—that can be used to refine product offerings, enhance support offerings and improve communication with partners.

Ad revenue forecasts slashed as regional news become the first media casualties of COVID-19.

Highlights  IBM scientists have measured how long information can stay in an individual atom  IBM breakthrough enables ability to actually record, study and visualize the magnetism of individual atoms at staggering speeds – one million times faster than previously possible  Could be valuable tool to study solar cells, quantum computing and storage-class memory at the nanoscale Today IBM researchers published a breakthrough technique in the peer-reviewed journal Science that measures how long a single atom can hold information, and giving scientists the ability to record, study and "visualize" extremely fast phenomena inside these atoms.

IBM today announced a research collaboratory in Singapore, where researchers from IBM intend to collaborate with scientists and engineers from public agencies in Singapore to improve the quality of its urban services. The focus of this research effort will be to use sensor networks to more effectively model, predict and manage the use of natural and physical infrastructure resources – water, transport and energy.  

IBM presenta Watson Virtual Agent en español, una solución que permite a las empresas construir un agente virtual para atención al cliente, flexible y fácil de configurar y adecuada a las necesidades de los negocios.

From 1 August young New Zealanders will have a safe virtual city, SciCity, in which they can explore, create and discover thanks to Otago Museum's Discovery World, IBM New Zealand, and ZeDDD Technology.

IBM's World Community Grid, a worldwide network of PC owners helping scientists solve humanitarian challenges, today announced several computing projects aimed at developing techniques to produce cleaner and safer water, an increasingly scarce commodity eluding at least 1.2 billion people worldwide.

One of Australia’s leading digital banks taps cognitive technology to simplify the home loan application process with innovative virtual assistan

IBM (NYSE: IBM ) today announced the local availability of the Virtual Desktop for Smart Business, a new workforce mobility solution offering anytime, anywhere, access to corporate data from mobile devices, such as tablets or laptops on the move.